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Benjamin Cravatt
Department of Cell Biology and Chemistry, The Scripps Research Institute, La Jolla, United States of America

Faculty Member: Chemical Biology > Macromolecular Chemistry [ since 6 July 2001 ]
[ Evaluations ]
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Evaluations

Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes.
Edgington LE, Berger AB, …, Lineberry N, Bogyo M
Nat Med 2009 Aug 15(8):967-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Cravatt
Evaluated 10 Sep 2009

An Activity-Based Protein Profiling Probe for the Nicotinic Acetylcholine Receptor.
Tantama M, Lin WC, Licht S
J Am Chem Soc 2008 Nov 1 130 [abstract on PubMed] [related articles] [full text]
Selected by | Benjamin Cravatt
Evaluated 9 Jan 2009

Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model.
Henderson WR, Chi EY, …, Rudensky AY, Gelb MH
J Exp Med 2007 Apr 16 204(4):865-77 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Benjamin Cravatt
Evaluated 15 Jan 2008

A chemical and genetic approach to the mode of action of fumagillin.
Zhang Y, Yeh JR, …, Holley SA, Crews CM
Chem Biol 2006 Sep 13(9):1001-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Cravatt
Evaluated 13 Mar 2007

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses.
Wei SH, Rosen H, …, Parker I, Cahalan MD
Nat Immunol 2005 Dec 6(12):1228-35 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Cravatt / Steve Ward
Evaluated 10 Jan 2006

In vivo protein biotinylation for identification of organ-specific antigens accessible from the vasculature.
Rybak JN, Ettorre A, …, Neri D, Elia G
Nat Methods 2005 Apr 2(4):291-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Cravatt
Evaluated 9 Jan 2006

Dysregulation of bacterial proteolytic machinery by a new class of antibiotics.
Brötz-Oesterhelt H, Beyer D, …, Sahl HG, Labischinski H
Nat Med 2005 Oct 11(10):1082-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Cravatt
Evaluated 18 Oct 2005

Library versus library recognition and inhibition of the HIV-1 Nef allelome.
Olszewski A, Weiss GA
J Am Chem Soc 2005 Sep 7 127(35):12178-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Cravatt / Stuart S Licht
Evaluated 14 Sep 2005

Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations.
Wong S, McLaughlin J, …, Shokat KM, Witte ON
Proc Natl Acad Sci U S A 2004 Dec 14 101(50):17456-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Benjamin Cravatt
Evaluated 20 Jun 2005

ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease.
Wu JY, Kao HJ, …, Millington D, Chen YT
J Clin Invest 2004 Feb 113(3):434-40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Benjamin Cravatt
Evaluated 14 Dec 2004

Molecular phenotyping of the pal1 and pal2 mutants of Arabidopsis thaliana reveals far-reaching consequences on phenylpropanoid, amino acid, and carbohydrate metabolism.
Rohde A, Morreel K, …, Messens E, Boerjan W
Plant Cell 2004 Oct 16(10):2749-71 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Benjamin Cravatt / Oliver Fiehn
Evaluated 14 Dec 2004

Discovery of the chemical function of glycosidases: design, synthesis, and evaluation of mass-differentiated carbohydrate libraries.
Yu Y, Ko KS, Zea CJ, Pohl NL
Org Lett 2004 Jun 10 6(12):2031-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Cravatt
Evaluated 17 Aug 2004

A chemoenzymatic approach toward the rapid and sensitive detection of O-GlcNAc posttranslational modifications.
Khidekel N, Arndt S, …, Qasba PK, Hsieh-Wilson LC
J Am Chem Soc 2003 Dec 31 125(52):16162-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Cravatt
Evaluated 3 Mar 2004

Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain.
Bisogno T, Howell F, …, Di Marzo V, Doherty P
J Cell Biol 2003 Nov 10 163(3):463-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Benjamin Cravatt
Evaluated 3 Mar 2004

Modulation of anxiety through blockade of anandamide hydrolysis.
Kathuria S, Gaetani S, …, Cuomo V, Piomelli D
Nat Med 2003 Jan 9(1):76-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Cravatt
Evaluated 25 Jun 2003

Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies.
Sun J, Pons J, Craik CS
Biochemistry 2003 Feb 4 42(4):892-900 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Cravatt
Evaluated 25 Jun 2003

Selective stabilization of the chorismate mutase transition state by a positively charged hydrogen bond donor.
Kienhöfer A, Kast P, Hilvert D
J Am Chem Soc 2003 Mar 19 125(11):3206-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arieh Warshel / Benjamin Cravatt
Evaluated 27 May 2003

Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity.
Yamamoto Y, Tsutsumi Y, …, Nagata S, Mayumi T
Nat Biotechnol 2003 May 21(5):546-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Cravatt
Evaluated 19 May 2003

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Mandala S, Hajdu R, …, Parsons W, Rosen H
Science 2002 Apr 12 296(5566):346-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Benjamin Cravatt / Siamon Gordon
Evaluated 19 Jul 2002

Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase.
Wise E, Yew WS, …, Gerlt JA, Rayment I
Biochemistry 2002 Mar 26 41(12):3861-9 [abstract on PubMed] [related articles] [order article]
Selected by | Benjamin Cravatt
Evaluated 18 Jul 2002

Comparison of one-dimensional and two-dimensional gel electrophoresis as a separation tool for proteomic analysis of rat liver microsomes: cytochromes P450 and other membrane proteins.
Galeva N, Altermann M
Proteomics 2002 Jun 2(6):713-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Cravatt
Evaluated 18 Jul 2002

Presynaptic specificity of endocannabinoid signaling in the hippocampus.
Wilson RI, Kunos G, Nicoll RA
Neuron 2001 Aug 16 31(3):453-62 [abstract on PubMed] [related articles] [order article]
Selected by | Benjamin Cravatt
Evaluated 25 Jan 2002

Regulation of cell survival by secreted proneurotrophins.
Lee R, Kermani P, Teng KK, Hempstead BL
Science 2001 Nov 30 294(5548):1945-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Moses Chao / Benjamin Cravatt
Evaluated 25 Jan 2002

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.
Grozinger CM, Chao ED, …, Moazed D, Schreiber SL
J Biol Chem 2001 Oct 19 276(42):38837-43 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Benjamin Cravatt / Peter Belshaw
Evaluated 8 Nov 2001

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.
Suzuki Y, Imai Y, …, Takio K, Takahashi R
Mol Cell 2001 Sep 8(3):613-21 [abstract on PubMed] [related articles] [order article]
Selected by | Benjamin Cravatt / Sharad Kumar / Bruce Hay / John Abrams
Evaluated 1 Nov 2001

Trace amines: identification of a family of mammalian G protein-coupled receptors.
Borowsky B, Adham N, …, Branchek TA, Gerald C
Proc Natl Acad Sci U S A 2001 Jul 31 98(16):8966-71 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Benjamin Cravatt
Evaluated 30 Oct 2001

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