 | Klaus Ley
Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology, La Jolla, United States of America | | | Faculty Member: Cell Biology > Cell Adhesion [ since 14 May 2003 ] |
| | [ Biography ] [ Homepage ] [ Evaluations ] | Biography
My research interest is focused on myeloid cells, specifically neutrophil and monocyte recruitment. Since 1980, I have published more than 200 original papers in peer-reviewed journals including Nature and Science. In 1991, I discovered that L-selectin was involved in leukocyte rolling in vivo. In 2007, my lab discovered a fundamental new signaling mechanism in neutrophils that appears to be very important in neutrophil recruitment. For my work on neutrophils and monocytes, I received the 2008 Bonazinga Award, the highest award of the Society for Leukocyte Biology.
RESEARCH INTERESTS
GENERAL:
1. Physiology and pathology of inflammation
2. Physiology and biophysics of leukocyte adhesion
3. Translational research in inflammation, atherosclerosis, inflammatory bowel disease
4. Bioinformatics and physiological genomics
SPECIFIC:
1. Molecular mechanisms of leukocyte and monocyte rolling, adhesion, and transmigration
2. Neutrophil activation during rolling
3. Biomechanics of leukocyte rolling and adhesion
4. Role of leukocyte adhesion molecules and chemokines in atherosclerosis, inflammatory bowel disease and acute lung injury
5. Regulation of granulopoiesis
| Home page
http://www.liai.org/pages/faculty-ley |
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