Biography
Education:
- BS (Chemistry), Juniata College, Huntingdon, Pennsylvania, USA.
- PhD (Physical Chemistry). Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
- Post-Doctoral Fellow, Harvard University, Cambridge, Massachusetts, USA
Awards:
- Merck Award, American Society of Biochemistry and Molecular Biology (2009)
- Elected Fellow, American Academy of Arts and Sciences (2008)
- Richard Lounsbery Award, US National Academy of Sciences (2005)
- Elected Member, US National Academy of Sciences (2001)
- Cornelius Rhoads Memorial Award, American Association for Cancer Research (1999)
- Eli Lilly Award of the American Chemical Society (1998)
- DuPont-Merck Award of the Protein Society (1997)
- Schering-Plough Award of the American Society of Biochemistry and Molecular Biology (1994)
Memberships:
- Board of Scientific Counselors, National Cancer Institute (2001-2005)
Editorial Board Memberships:
- Proceedings of the National Academy of Sciences (USA)
- Cell
- Structure
- Genes & Development
- Advances in Protein Chemistry
Research Interests:
Structural biology of cellular signaling and DNA replication signal transduction.
Our laboratory explores how particular structures and atomic interactions underlie the transmission of information from the cell surface to the nucleus and the components of chromosomal DNA replication. We study STAT proteins that directly couple receptor activation to gene transcription, tyrosine kinases such as the product of the src oncogene, and protein kinases and phosphatases that act on serine and threonine. The laboratory also conducts structural analysis of the highly processive DNA polymerases responsible for chromosomal replication to understand the mechanisms and regulation of these enzymes.
|
