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Edward Egelman
University of Virginia School of Medicine, United States of America

Faculty Member: Structural Biology > Structure: Replication & Repair [ since 11 July 2001 ]
[ Evaluations ]
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Evaluations

Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation.
Popp D, Xu W, …, Robinson RC, Schumacher M
J Biol Chem 2010 Jan 27 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 8 Feb 2010

An SOS inhibitor that binds to free RecA protein: the PsiB protein.
Petrova V, Chitteni-Pattu S, …, Inman RB, Cox MM
Mol Cell 2009 Oct 9 36(1):121-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 23 Oct 2009

Structural transitions within human Rad51 nucleoprotein filaments.
Robertson RB, Moses DN, …, Sung P, Greene EC
Proc Natl Acad Sci U S A 2009 Jul 21 [abstract on PubMed] [related articles] [full text]
Selected by | Edward Egelman
Evaluated 3 Aug 2009

Mechanistic basis of 5'-3' translocation in SF1B helicases.
Saikrishnan K, Powell B, …, Webb MR, Wigley DB
Cell 2009 May 29 137(5):849-59 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 15 Jun 2009

A nebulin ruler does not dictate thin filament lengths.
Castillo A, Nowak R, …, Fowler VM, Littlefield RS
Biophys J 2009 Mar 4 96(5):1856-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 12 Mar 2009

Mal3, the Schizosaccharomyces pombe homolog of EB1, changes the microtubule lattice.
des Georges A, Katsuki M, …, Cross RA, Amos LA
Nat Struct Mol Biol 2008 Oct 15(10):1102-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman / Anna Akhmanova
Evaluated 17 Oct 2008

Structural basis for inhibition of homologous recombination by the RecX protein.
Ragone S, Maman JD, Furnham N, Pellegrini L
EMBO J 2008 Jul 24 [abstract on PubMed] [related articles] [full text]
Selected by | Edward Egelman
Evaluated 12 Aug 2008

Bacterial actin: architecture of the ParMRC plasmid DNA partitioning complex.
Salje J, Löwe J
EMBO J 2008 Jul 24 [abstract on PubMed] [related articles] [full text]
Selected by | Linda Amos / Edward Egelman / Mithilesh Mishra and Ramanujam Srinivasan and Mohan Balasubramanian
Evaluated 12 Aug 2008

Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures.
Chen Z, Yang H, Pavletich NP
Nature 2008 May 22 453(7194):489-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman / Donald Rio
Evaluated 3 Jun 2008

Nucleotide-mediated conformational changes of monomeric actin and Arp3 studied by molecular dynamics simulations.
Dalhaimer P, Pollard TD, Nolen BJ
J Mol Biol 2008 Feb 8 376(1):166-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 9 Jan 2008

Structure of the Tertiary Complex of the RepA Hexameric Helicase of Plasmid RSF1010 with the ssDNA and Nucleotide Cofactors in Solution.
Marcinowicz A, Jezewska MJ, Bujalowski PJ, Bujalowski W
Biochemistry 2007 Oct 16 [Epub ahead of print] [abstract on PubMed] [related articles] [full text]
Selected by | Edward Egelman
Evaluated 25 Oct 2007

Single-molecule studies reveal dynamics of DNA unwinding by the ring-shaped T7 helicase.
Johnson DS, Bai L, …, Patel SS, Wang MD
Cell 2007 Jun 29 129(7):1299-309 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 24 Aug 2007

Versatile fluorescent probes for actin filaments based on the actin-binding domain of utrophin.
Burkel BM, von Dassow G, Bement WM
Cell Motil Cytoskeleton 2007 Nov 64(11):822-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 24 Aug 2007

Crystal structures of an ATP-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon Sulfolobus tokodaii.
Nishimasu H, Fushinobu S, Shoun H, Wakagi T
J Biol Chem 2007 Mar 30 282(13):9923-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 2 May 2007

UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke.
Lee JY, Yang W
Cell 2006 Dec 29 127(7):1349-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman / Malcolm White
Evaluated 15 Jan 2007

Crystal structure of polymerization-competent actin.
Klenchin VA, Khaitlina SY, Rayment I
J Mol Biol 2006 Sep 8 362(1):140-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 23 Aug 2006

Effect of the substitution of muscle actin-specific subdomain 1 and 2 residues in yeast actin on actin function.
McKane M, Wen KK, Meyer A, Rubenstein PA
J Biol Chem 2006 Oct 6 281(40):29916-28 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 21 Aug 2006

Oligomeric states of bacteriophage T7 gene 4 primase/helicase.
Crampton DJ, Ohi M, …, Walz T, Richardson CC
J Mol Biol 2006 Jul 14 360(3):667-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 21 Jun 2006

Crystallographic identification of an ordered C-terminal domain and a second nucleotide-binding site in RecA: new insights into allostery.
Krishna R, Manjunath GP, …, Muniyappa K, Vijayan M
Nucleic Acids Res 2006 34(8):2186-95 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 15 May 2006

Dystrophin and utrophin bind actin through distinct modes of contact.
Rybakova IN, Humston JL, Sonnemann KJ, Ervasti JM
J Biol Chem 2006 Apr 14 281(15):9996-10001 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 28 Feb 2006

Dual requirement for flexibility and specificity for binding of the coiled-coil tropomyosin to its target, actin.
Singh A, Hitchcock-DeGregori SE
Structure 2006 Jan 14(1):43-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 16 Jan 2006

Protein structures forming the shell of primitive bacterial organelles.
Kerfeld CA, Sawaya MR, …, Beeby M, Yeates TO
Science 2005 Aug 5 309(5736):936-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Tony Crowther / Edward Egelman / Celerino Abad-Zapatero
Evaluated 5 Oct 2005

DNA synthesis provides the driving force to accelerate DNA unwinding by a helicase.
Stano NM, Jeong YJ, …, Levin MK, Patel SS
Nature 2005 May 19 435(7040):370-3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman / Manju Hingorani
Evaluated 27 May 2005

Solution structure of the helicase-interaction domain of the primase DnaG: a model for helicase activation.
Syson K, Thirlway J, …, Soultanas P, Waltho JP
Structure 2005 Apr 13(4):609-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 3 May 2005

DNA polymerase V and RecA protein, a minimal mutasome.
Schlacher K, Leslie K, …, Cox MM, Goodman MF
Mol Cell 2005 Feb 18 17(4):561-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 7 Mar 2005

Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain.
Otomo T, Tomchick DR, …, Machius M, Rosen MK
Nature 2005 Feb 3 433(7025):488-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman / Marie-France Carlier / Alfred Wittinghofer / R. Dyche Mullins
Evaluated 18 Jan 2005

Structural insights into FtsZ protofilament formation.
Oliva MA, Cordell SC, Löwe J
Nat Struct Mol Biol 2004 Dec 11(12):1243-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 7 Dec 2004

Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP.
Nolen BJ, Littlefield RS, Pollard TD
Proc Natl Acad Sci U S A 2004 Nov 2 101(44):15627-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 2 Nov 2004

Crystal structure of archaeal recombinase RADA: a snapshot of its extended conformation.
Wu Y, He Y, …, Qian X, Luo Y
Mol Cell 2004 Aug 13 15(3):423-35 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 20 Aug 2004

Crystal structure of a Rad51 filament.
Conway AB, Lynch TW, …, Symington LS, Rice PA
Nat Struct Mol Biol 2004 Aug 11(8):791-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 19 Jul 2004

Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange.
Sehorn MG, Sigurdsson S, …, Unger VM, Sung P
Nature 2004 May 27 429(6990):433-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman
Evaluated 15 Jun 2004

Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1.
Kinebuchi T, Kagawa W, …, Kurumizaka H, Yokoyama S
Mol Cell 2004 May 7 14(3):363-74 [abstract on PubMed] [related articles] [order article]
Selected by | Edward Egelman
Evaluated 25 May 2004

The DNA-unwinding mechanism of the ring helicase of bacteriophage T7.
Jeong YJ, Levin MK, Patel SS
Proc Natl Acad Sci U S A 2004 May 11 101(19):7264-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 18 May 2004

Physical interaction between replication protein A and Rad51 promotes exchange on single-stranded DNA.
Stauffer ME, Chazin WJ
J Biol Chem 2004 Jun 11 279(24):25638-45 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 13 Apr 2004

In vivo roles of Rad52, Rad54, and Rad55 proteins in Rad51-mediated recombination.
Sugawara N, Wang X, Haber JE
Mol Cell 2003 Jul 12(1):209-19 [abstract on PubMed] [related articles] [order article]
Selected by | Edward Egelman
Evaluated 30 Sep 2003

Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading.
Skordalakes E, Berger JM
Cell 2003 Jul 11 114(1):135-46 [abstract on PubMed] [related articles] [order article]
Selected by | Russell DiGate / Stephen Busby / Edward Egelman
Evaluated 29 Jul 2003

Modular architecture of the bacteriophage T7 primase couples RNA primer synthesis to DNA synthesis.
Kato M, Ito T, …, Richardson CC, Ellenberger T
Mol Cell 2003 May 11(5):1349-60 [abstract on PubMed] [related articles] [order article]
Selected by | Edward Egelman
Evaluated 10 Jun 2003

Hallmarks of homology recognition by RecA-like recombinases are exhibited by the unrelated Escherichia coli RecT protein.
Noirot P, Gupta RC, Radding CM, Kolodner RD
EMBO J 2003 Jan 15 22(2):324-34 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 17 Jan 2003

Circadian clock protein KaiC forms ATP-dependent hexameric rings and binds DNA.
Mori T, Saveliev SV, …, Inman RB, Johnson CH
Proc Natl Acad Sci U S A 2002 Dec 24 99(26):17203-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 9 Jan 2003

F-actin-like filaments formed by plasmid segregation protein ParM.
van den Ent F, Møller-Jensen J, …, Gerdes K, Löwe J
EMBO J 2002 Dec 16 21(24):6935-43 [abstract on PubMed] [related articles] [order article]
Selected by | Edward Egelman / Jose Valpuesta / Marie-France Carlier
Evaluated 9 Jan 2003

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Pellegrini L, Yu DS, …, Blundell TL, Venkitaraman AR
Nature 2002 Nov 21 420(6913):287-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Egelman / Shiv Pillai / Sylvie Doublie / Song Tan
Evaluated 21 Nov 2002

Interaction of adjacent primase domains within the hexameric gene 4 helicase-primase of bacteriophage T7.
Lee SJ, Richardson CC
Proc Natl Acad Sci U S A 2002 Oct 1 99(20):12703-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 23 Oct 2002

Two distinct modes of RecA action are required for DNA polymerase V-catalyzed translesion synthesis.
Pham P, Seitz EM, …, Cox MM, Goodman MF
Proc Natl Acad Sci U S A 2002 Aug 20 99(17):11061-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 29 Aug 2002

The RecA proteins of Deinococcus radiodurans and Escherichia coli promote DNA strand exchange via inverse pathways.
Kim JI, Cox MM
Proc Natl Acad Sci U S A 2002 Jun 11 99(12):7917-21 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 15 Jul 2002

Biochemical characterization of the human RAD51 protein. I. ATP hydrolysis.
Tombline G, Fishel R
J Biol Chem 2002 Apr 26 277(17):14417-25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 2 May 2002

Structural studies of the scrapie prion protein by electron crystallography.
Wille H, Michelitsch MD, …, Agard DA, Prusiner SB
Proc Natl Acad Sci U S A 2002 Mar 19 99(6):3563-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 20 Mar 2002

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