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Francisco Garcia-del Portillo
Department of Microbial Biotechnology, Centro Nacional de Biotecnologia - CSIC, Madrid, Spain

Faculty Member: Microbiology > Cellular Microbiology & Pathogenesis [ since 3 March 2003 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

1989.
Ph.D. in Molecular Biology at the 'Centro de Biología Molecular Severo Ochoa', Universidad Autónoma de Madrid, Spain.
Topic: Role of penicillin-binding proteins (PBPs) during the cell cycle of Escherichia coli.
1991-1994.
EMBO and Medical Research of Canada (MRC) postdoctoral fellow in the group of Prof. B. Brett Finlay. Biotechnology Laboratory, University of British Columbia, Vancouver, Canada.
Topic: Biogenesis and intracellular trafficking of Salmonella-containing vacuoles (SCV) in epithelial cells.
1995-2000.
Assistant Professor at the Department of Molecular Biology of the 'Universidad Autónoma de Madrid'.
Topics:
a) Interaction of Salmonella with fibroblast cells and biosynthesis of peptidoglycan in intracellular bacteria.
b) Sequencing of the Listeria monocytogenes genome. Identification of peptidoglycan-bound surface proteins.
2000-presen.
Researcher of the 'Consejo Superior de Investigaciones Científicas' (CSIC) at the 'Centro Nacional de Biotecnología' (CNB). Head of the laboratory of 'Microbial Pathogenesis'.
Topics:
a) Control of Salmonella intracellular growth within eukaryotic cells
b) The Listeria cell wall proteome

Home page

http://www.cnb.uam.es/~salmolis/

to email [Help]
Evaluations

Transcriptome complexity in a genome-reduced bacterium.
Güell M, van Noort V, …, Bork P, Serrano L
Science 2009 Nov 27 326(5957):1268-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francisco Garcia-del Portillo
Evaluated 18 Dec 2009

D-amino acids govern stationary phase cell wall remodeling in bacteria.
Lam H, Oh DC, …, de Pedro MA, Waldor MK
Science 2009 Sep 18 325(5947):1552-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle / Martin Marinus / Francisco Garcia-del Portillo
Evaluated 12 Nov 2009

Eradication of Intracellular Salmonella Typhimurium with a Small-Molecule, Host Cell-Directed Agent.
Chiu HC, Kulp SK, …, Schlesinger LS, Chen CS
Antimicrob Agents Chemother 2009 Oct 5 [abstract on PubMed] [related articles] [full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 11 Nov 2009

Salmonella Infection of Gallbladder Epithelial Cells Drives Local Inflammation and Injury in a Model of Acute Typhoid Fever.
Menendez A, Arena ET, …, Vogl W, Finlay BB
J Infect Dis 2009 Oct 23 [abstract on PubMed] [related articles] [full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 11 Nov 2009

The Listeria transcriptional landscape from saprophytism to virulence.
Toledo-Arana A, Dussurget O, …, Johansson J, Cossart P
Nature 2009 Jun 18 459(7249):950-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francisco Garcia-del Portillo / Kelly S. Bender and Judy Wall
Evaluated 21 May 2009

Host cell-free growth of the Q fever bacterium Coxiella burnetii.
Omsland A, Cockrell DC, …, Porcella SF, Heinzen RA
Proc Natl Acad Sci U S A 2009 Mar 17 106(11):4430-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francisco Garcia-del Portillo
Evaluated 24 Mar 2009

Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells.
Roy K, Hilliard GM, …, Ostmann MM, Fleckenstein JM
Nature 2009 Jan 29 457(7229):594-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francisco Garcia-del Portillo
Evaluated 3 Feb 2009


Cytolocalization of the PhoP response regulator in Salmonella enterica: modulation by extracellular Mg2+ and by the SCV environment.
Sciara MI, Spagnuolo C, Jares-Erijman E, García Véscovi E
Mol Microbiol 2008 Oct 70(2):479-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francisco Garcia-del Portillo
Evaluated 3 Nov 2008

Peptide-assisted degradation of the Salmonella MgtC virulence factor.
Alix E, Blanc-Potard AB
EMBO J 2008 Feb 6 27(3):546-57 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francisco Garcia-del Portillo
Evaluated 21 Aug 2008

Sorting nexin-1 defines an early phase of Salmonella-containing vacuole-remodeling during Salmonella infection.
Bujny MV, Ewels PA, …, Jepson MA, Cullen PJ
J Cell Sci 2008 Jun 15 121(Pt 12):2027-36 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 10 Jun 2008

Analysis of Cells Targeted by Salmonella Type III Secretion In Vivo.
Geddes K, Cruz F, Heffron F
PLoS Pathog 2007 Dec 21 3(12):e196 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 11 Jan 2008

Hemophagocytic Macrophages Harbor Salmonella enterica during Persistent Infection.
Nix RN, Altschuler SE, Henson PM, Detweiler CS
PLoS Pathog 2007 Dec 14 3(12):e193 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 11 Jan 2008

Legionella pneumophila proteins that regulate Rab1 membrane cycling.
Ingmundson A, Delprato A, Lambright DG, Roy CR
Nature 2007 Nov 15 450(7168):365-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jacqueline Cherfils / Vojo Deretic / Stefan Kaufmann / Francisco Garcia-del Portillo / Carleen Collins
Evaluated 6 Dec 2007

Injection of flagellin into the host cell cytosol by Salmonella enterica serotype Typhimurium.
Sun YH, Rolán HG, Tsolis RM
J Biol Chem 2007 Nov 23 282(47):33897-901 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francisco Garcia-del Portillo / Charles Bevins
Evaluated 19 Oct 2007

Ubiquitin-Yop hybrids as probes for post-translational transport by the Yersinia type III secretion pathway.
Quenee LE, Schneewind O
Mol Microbiol 2007 Jul 65(2):386-400 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francisco Garcia-del Portillo
Evaluated 16 Jul 2007

Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus.
Gründling A, Schneewind O
Proc Natl Acad Sci U S A 2007 May 15 104(20):8478-83 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 18 May 2007

TBK1 protects vacuolar integrity during intracellular bacterial infection.
Radtke AL, Delbridge LM, …, Barber GN, O'Riordan MX
PLoS Pathog 2007 Mar 3(3):e29 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 12 Mar 2007

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system.
Boneca IG, Dussurget O, …, Cossart P, Girardin SE
Proc Natl Acad Sci U S A 2007 Jan 16 104(3):997-1002 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo / Paul Cotter / Etienne Joly / Lora Hooper / John Mansfield
Evaluated 22 Jan 2007

Salmonella typhimurium disseminates within its host by manipulating the motility of infected cells.
Worley MJ, Nieman GS, Geddes K, Heffron F
Proc Natl Acad Sci U S A 2006 Nov 21 103(47):17915-20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo / James Bliska / Ariel Blocker
Evaluated 17 Nov 2006

Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Patel JC, Galán JE
J Cell Biol 2006 Nov 6 175(3):453-63 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Guy Tran Van Nhieu / Francisco Garcia-del Portillo / Emmanuelle Caron
Evaluated 17 Nov 2006

Signal sequence directs localized secretion of bacterial surface proteins.
Carlsson F, Stålhammar-Carlemalm M, …, Carlemalm E, Lindahl G
Nature 2006 Aug 24 442(7105):943-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Victor DiRita / Tracy Palmer / Karin Romisch / Francisco Garcia-del Portillo / Marc Lecuit / Rino Rappuoli / Jean Pieters
Evaluated 6 Sep 2006

Invasion of host cells by Salmonella typhimurium requires focal adhesion kinase and p130Cas.
Shi J, Casanova JE
Mol Biol Cell 2006 Nov 17(11):4698-708 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 29 Aug 2006

Assembly of the inner rod determines needle length in the type III secretion injectisome.
Marlovits TC, Kubori T, …, Unger VM, Galán JE
Nature 2006 Jun 1 441(7093):637-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francisco Garcia-del Portillo / Tracy Raivio
Evaluated 12 Jun 2006

Coexpression of virulence and fosfomycin susceptibility in Listeria: molecular basis of an antimicrobial in vitro-in vivo paradox.
Scortti M, Lacharme-Lora L, …, Losito P, Vázquez-Boland JA
Nat Med 2006 May 12(5):515-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Lecuit / Francisco Garcia-del Portillo / Paul Cotter
Evaluated 30 May 2006

Robust Salmonella metabolism limits possibilities for new antimicrobials.
Becker D, Selbach M, …, Mann M, Bumann D
Nature 2006 Mar 16 440(7082):303-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francisco Garcia-del Portillo / Victor Nizet / Jean Pieters
Evaluated 21 Mar 2006

Genome-wide screen for Salmonella genes required for long-term systemic infection of the mouse.
Lawley TD, Chan K, …, Govoni GR, Monack DM
PLoS Pathog 2006 Feb 2(2):e11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 14 Mar 2006

Salmonella enterica highly expressed genes are disease specific.
Rollenhagen C, Bumann D
Infect Immun 2006 Mar 74(3):1649-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 3 Mar 2006

Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1.
Zhang Y, Higashide W, …, Sherman DM, Zhou D
J Biol Chem 2005 Nov 18 280(46):38682-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 1 Dec 2005

Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine.
Brown NF, Vallance BA, …, Coburn BA, Finlay BB
PLoS Pathog 2005 Nov 1(3):e32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 30 Nov 2005

Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid.
Coombes BK, Wickham ME, …, Brown NF, Finlay BB
Proc Natl Acad Sci U S A 2005 Nov 29 102(48):17460-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 30 Nov 2005

Real-time imaging of type III secretion: Salmonella SipA injection into host cells.
Schlumberger MC, Müller AJ, …, Stecher B, Hardt WD
Proc Natl Acad Sci U S A 2005 Aug 30 102(35):12548-53 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jean-Pierre Gorvel / Ilan Rosenshine / Drusilla Burns / Francisco Garcia-del Portillo / Jürgen Heesemann / Craig Roy
Evaluated 16 Sep 2005

sciS, an icmF homolog in Salmonella enterica serovar Typhimurium, limits intracellular replication and decreases virulence.
Parsons DA, Heffron F
Infect Immun 2005 Jul 73(7):4338-45 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 29 Jun 2005

Formation of a novel surface structure encoded by Salmonella Pathogenicity Island 2.
Chakravortty D, Rohde M, …, Deiwick J, Hensel M
EMBO J 2005 Jun 1 24(11):2043-52 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 19 May 2005

A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP.
Hisert KB, MacCoss M, …, Murray D, Nathan C
Mol Microbiol 2005 Jun 56(5):1234-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francisco Garcia-del Portillo / Ferric Fang
Evaluated 13 May 2005

Cryo-electron microscopy reveals native polymeric cell wall structure in Bacillus subtilis 168 and the existence of a periplasmic space.
Matias VR, Beveridge TJ
Mol Microbiol 2005 Apr 56(1):240-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tracy Palmer / Francisco Garcia-del Portillo
Evaluated 30 Mar 2005

Anchor structure of staphylococcal surface proteins. V. Anchor structure of the sortase B substrate IsdC.
Marraffini LA, Schneewind O
J Biol Chem 2005 Apr 22 280(16):16263-71 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 2 Mar 2005

Brucella coopts the small GTPase Sar1 for intracellular replication.
Celli J, Salcedo SP, Gorvel JP
Proc Natl Acad Sci U S A 2005 Feb 1 102(5):1673-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo / Craig Roy
Evaluated 17 Jan 2005

Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathway.
Lyons S, Wang L, …, Merlin D, Gewirtz AT
J Cell Sci 2004 Nov 15 117(Pt 24):5771-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 2 Nov 2004

Isolation of Mycobacterium tuberculosis mutants defective in the arrest of phagosome maturation.
Pethe K, Swenson DL, …, Wang C, Russell DG
Proc Natl Acad Sci U S A 2004 Sep 14 101(37):13642-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Vojo Deretic / Francisco Garcia-del Portillo / Craig Roy
Evaluated 14 Sep 2004

Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional repressor required for virulence.
Gründling A, Burrack LS, Bouwer HG, Higgins DE
Proc Natl Acad Sci U S A 2004 Aug 17 101(33):12318-23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 17 Aug 2004

Proteomic screening and identification of differentially distributed membrane proteins in Escherichia coli.
Lai EM, Nair U, Phadke ND, Maddock JR
Mol Microbiol 2004 May 52(4):1029-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francisco Garcia-del Portillo
Evaluated 20 May 2004

Effector proteins encoded by Salmonella pathogenicity island 2 interfere with the microtubule cytoskeleton after translocation into host cells.
Kuhle V, Jäckel D, Hensel M
Traffic 2004 May 5(5):356-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Francisco Garcia-del Portillo
Evaluated 28 Apr 2004

Microtubule motors control membrane dynamics of Salmonella-containing vacuoles.
Guignot J, Caron E, …, Roy C, Holden DW
J Cell Sci 2004 Mar 1 117(Pt 7):1033-45 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein / Francisco Garcia-del Portillo
Evaluated 28 Apr 2004

Dynein-mediated vesicle transport controls intracellular Salmonella replication.
Marsman M, Jordens I, …, Janssen L, Neefjes J
Mol Biol Cell 2004 Jun 15(6):2954-64 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo / Sergio Grinstein
Evaluated 28 Apr 2004

Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+/+ mice and can be reactivated by IFNgamma neutralization.
Monack DM, Bouley DM, Falkow S
J Exp Med 2004 Jan 19 199(2):231-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Virginia Miller / Francisco Garcia-del Portillo
Evaluated 18 Feb 2004

The needle length of bacterial injectisomes is determined by a molecular ruler.
Journet L, Agrain C, Broz P, Cornelis GR
Science 2003 Dec 5 302(5651):1757-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Tracy Palmer / Francisco Garcia-del Portillo / Christoph Dehio / Rino Rappuoli
Evaluated 12 Dec 2003

ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells.
Guermonprez P, Saveanu L, …, Van Endert P, Amigorena S
Nature 2003 Sep 25 425(6956):397-402 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Colin Watts / Lutz Walter / Frank Momburg / Shiv Pillai / Francisco Garcia-del Portillo / Caetano Reis e Sousa / Judith Klumperman / Stefan Kaufmann / Sergio Grinstein
Evaluated 13 Oct 2003

Phagosomes are competent organelles for antigen cross-presentation.
Houde M, Bertholet S, …, Sacks D, Desjardins M
Nature 2003 Sep 25 425(6956):402-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Karin Romisch / Lutz Walter / Francisco Garcia-del Portillo / Caetano Reis e Sousa / Shiv Pillai / Frank Momburg / Stefan Kaufmann / Edward Collins / Paul Gleeson / Sergio Grinstein
Evaluated 8 Oct 2003

A lytic transglycosylase homologue, PleA, is required for the assembly of pili and the flagellum at the Caulobacter crescentus cell pole.
Viollier PH, Shapiro L
Mol Microbiol 2003 Jul 49(2):331-45 [abstract on PubMed] [related articles] [order article]
Selected by | Francisco Garcia-del Portillo
Evaluated 15 Jul 2003

The K1 capsule modulates trafficking of E. coli-containing vacuoles and enhances intracellular bacterial survival in human brain microvascular endothelial cells.
Kim KJ, Elliott SJ, …, Stins MF, Kim KS
Cell Microbiol 2003 Apr 5(4):245-52 [abstract on PubMed] [related articles] [order article]
Selected by | Francisco Garcia-del Portillo
Evaluated 8 Apr 2003

Expression of truncated Internalin A is involved in impaired internalization of some Listeria monocytogenes isolates carried asymptomatically by humans.
Olier M, Pierre F, …, Piveteau P, Guzzo J
Infect Immun 2003 Mar 71(3):1217-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 19 Mar 2003

A developmentally regulated two-component signal transduction system in Chlamydia.
Koo IC, Stephens RS
J Biol Chem 2003 May 9 278(19):17314-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Francisco Garcia-del Portillo
Evaluated 10 Mar 2003

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