John R. Couchman, Ph.D.
DNRF Professor
Biomedicinsk Institut
University of Copenhagen
Denmark

Ph.D. 1977 University of Wales, U.K.
1977-1985 Scientist and Senior Scientist, Unilever Research Laboratories, Bedford, U.K.
1985-1989 Assistant Professor of Cell Biology, University of Alabama at Birmingham
1989-1993 Associate Professor of Cell Biology, University of Alabama at Birmingham
1990-1995 established Investigator of The American Heart Association
1993-2000 Professor of Cell Biology, University of Alabama at Birmingham
1996-2000 Director, Cell Adhesion & Matrix Research Center, University of Alabama at Birmingham
2001-2007 Professor of Cell Biology, Imperial College of Science, Technology & Medicine, London, U.K.
2007-present DNRF Professor, Biomedicinsk Institut, University of Copenhagen

http://www.bric.ku.dk/research/Couchman_Group/

Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. Stanford KI, Bishop JR, …, Witztum JL, Esko JD J Clin Invest 2009 Oct 1 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman Evaluated 2 Nov 2009 Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Echtermeyer F, Bertrand J, …, Theilmeier G, Pap T Nat Med 2009 Sep 15(9):1072-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Couchman / Mark Morgan and Martin Humphries / Yu Yamaguchi Evaluated 27 Aug 2009 Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses. Chan JA, Balasubramanian S, …, Thompson M, Segal RA Nat Neurosci 2009 Apr 12(4):409-17 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Couchman / Zeng-jie Yang and Robert Wechsler-Reya / Chaya Kalcheim Evaluated 19 May 2009 Syndecan-1 regulates {alpha}v{beta}3 and {alpha}v{beta}5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC J Exp Med 2009 Mar 2 [abstract on PubMed] [related articles] [full text] Selected by | John Couchman Evaluated 6 Mar 2009 Contact inhibition of locomotion in vivo controls neural crest directional migration. Carmona-Fontaine C, Matthews HK, …, Stern CD, Mayor R Nature 2008 Dec 18 456(7224):957-61 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Harukazu Nakamura / Christopher Marshall / John Couchman / Clemens Kiecker and Andrew Lumsden / Jeffrey Axelrod / David Wilkinson Evaluated 9 Jan 2009 Nanoscale organization of hedgehog is essential for long-range signaling. Vyas N, Goswami D, …, Sowdhamini R, Mayor S Cell 2008 Jun 27 133(7):1214-27 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Couchman Evaluated 4 Sep 2008 p190RhoGAP is the convergence point of adhesion signals from {alpha}5{beta}1 integrin and syndecan-4. Bass MD, Morgan MR, …, Goryachev AB, Humphries MJ J Cell Biol 2008 Jun 9 181 [abstract on PubMed] [related articles] [full text] Selected by | John Couchman Evaluated 19 Jun 2008 A translational block to HSPG synthesis permits BMP signaling in the early Drosophila embryo. Bornemann DJ, Park S, Phin S, Warrior R Development 2008 Mar 135(6):1039-47 [abstract on PubMed] [related articles] [FREE full text] Selected by | Norbert Perrimon / John Couchman Evaluated 6 Mar 2008 Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1. de Witte L, Bobardt M, …, Geijtenbeek TB, Gallay P Proc Natl Acad Sci U S A 2007 Dec 4 104(49):19464-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Couchman Evaluated 18 Dec 2007 Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate. Escobar Galvis ML, Jia J, …, Lindahl U, Li JP Nat Chem Biol 2007 Dec 3(12):773-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Couchman Evaluated 28 Nov 2007 Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. Little CB, Meeker CT, …, Smith SM, Fosang AJ J Clin Invest 2007 Jun 117(6):1627-36 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman Evaluated 27 Jul 2007 Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development. Abramsson A, Kurup S, …, Betsholtz C, Gerhardt H Genes Dev 2007 Feb 1 21(3):316-31 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Couchman Evaluated 21 Feb 2007 Hyaluronan and CD44 antagonize mitogen-dependent cyclin D1 expression in mesenchymal cells. Kothapalli D, Zhao L, …, Puré E, Assoian RK J Cell Biol 2007 Feb 12 176(4):535-44 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman Evaluated 20 Feb 2007 Cell-surface heparan sulfate proteoglycans are essential components of the unconventional export machinery of FGF-2. Zehe C, Engling A, …, Schäfer T, Nickel W Proc Natl Acad Sci U S A 2006 Oct 17 103(42):15479-84 [abstract on PubMed] [related articles] [FREE full text] Selected by | Alain Prochiantz / John Couchman Evaluated 7 Nov 2006 Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling. Kamimura K, Koyama T, …, Kimata K, Nakato H J Cell Biol 2006 Sep 11 174(6):773-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Andrew Chisholm / John Couchman / Norbert Perrimon / Jean-Paul Vincent Evaluated 26 Sep 2006 FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Ohta Y, Hartwig JH, Stossel TP Nat Cell Biol 2006 Aug 8(8):803-14 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Couchman Evaluated 21 Aug 2006 HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. Uchimura K, Morimoto-Tomita M, …, Werb Z, Rosen SD BMC Biochem 2006 7:2 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman Evaluated 7 Apr 2006 Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos. Muñoz R, Moreno M, …, Orbenes C, Larraín J Nat Cell Biol 2006 May 8(5):492-500 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Couchman / Douglas DeSimone / Herbert Steinbeisser / Lance Davidson / Jeffrey Axelrod Evaluated 5 Apr 2006 The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase. Fox AN, Zinn K Curr Biol 2005 Oct 11 15(19):1701-11 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Couchman / Ken Irvine Evaluated 11 Nov 2005 Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactions. Mortier E, Wuytens G, …, David G, Zimmermann P EMBO J 2005 Jul 20 24(14):2556-65 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman Evaluated 2 Aug 2005 Palmitoylation supports assembly and function of integrin-tetraspanin complexes. Yang X, Kovalenko OV, …, Stipp CS, Hemler ME J Cell Biol 2004 Dec 20 167(6):1231-40 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman Evaluated 7 Jan 2005 Myosin-X provides a motor-based link between integrins and the cytoskeleton. Zhang H, Berg JS, …, Cheney RE, Strömblad S Nat Cell Biol 2004 Jun 6(6):523-31 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Couchman / Alan Rick Horwitz Evaluated 14 Jun 2004 Carbohydrate-carbohydrate interaction provides adhesion force and specificity for cellular recognition. Bucior I, Scheuring S, Engel A, Burger MM J Cell Biol 2004 May 24 165(4):529-37 [abstract on PubMed] [related articles] [FREE full text] Selected by | Sheila McCormick / John Couchman / Deborah Leckband Evaluated 14 Jun 2004 Mammalian brain morphogenesis and midline axon guidance require heparan sulfate. Inatani M, Irie F, …, Tessier-Lavigne M, Yamaguchi Y Science 2003 Nov 7 302(5647):1044-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | David Van Vactor / John Couchman Evaluated 27 Nov 2003 A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. Violin JD, Zhang J, Tsien RY, Newton AC J Cell Biol 2003 Jun 9 161(5):899-909 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman Evaluated 26 Jun 2003 A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins. McDowall A, Inwald D, …, Klein N, Hogg N J Clin Invest 2003 Jan 111(1):51-60 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman / Dietmar Vestweber / Martin Humphries Evaluated 24 Jan 2003 EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). Carter N, Nakamoto T, Hirai H, Hunter T Nat Cell Biol 2002 Aug 4(8):565-73 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Couchman Evaluated 9 Aug 2002 PIP(2)-PDZ domain binding controls the association of syntenin with the plasma membrane. Zimmermann P, Meerschaert K, …, David G, Gettemans J Mol Cell 2002 Jun 9(6):1215-25 [abstract on PubMed] [related articles] [order article] Selected by | John Couchman / Andreas Wodarz / Craig Montell / Martin Humphries Evaluated 3 Jul 2002 Resolution of lung inflammation by CD44. Teder P, Vandivier RW, …, Henson PM, Noble PW Science 2002 Apr 5 296(5565):155-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman Evaluated 24 Apr 2002 Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Xiong JP, Stehle T, …, Goodman SL, Arnaout MA Science 2002 Apr 5 296(5565):151-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman / Robert Liddington / Vance Lemmon / Alfred Wittinghofer / Martin Humphries Evaluated 24 Apr 2002 Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI. Del Pozo MA, Kiosses WB, …, Hahn KM, Schwartz MA Nat Cell Biol 2002 Mar 4(3):232-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Couchman / Kristiina Vuori / Denise Montell / Martin Humphries / Charles Streuli Evaluated 8 Mar 2002 Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation. Huang W, Chiquet-Ehrismann R, …, Garcia-Pardo A, Orend G Cancer Res 2001 Dec 1 61(23):8586-94 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman Evaluated 24 Jan 2002 Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling: evidence in support of the "cooperative end structures" model. Zhang Z, Coomans C, David G J Biol Chem 2001 Nov 9 276(45):41921-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman Evaluated 23 Oct 2001

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