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John S Lazo
Department of Pharmacology, University of Pittsburgh, Pittsburgh, United States of America

Faculty Member: Pharmacology & Drug Discovery > Molecular Pharmacology [ since 31 May 2006 ]
[ Evaluations ]
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Evaluations

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis.
Spencer SL, Gaudet S, …, Burke JM, Sorger PK
Nature 2009 May 21 459(7245):428-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rizwan Haq and David Fisher / Yutaka Tagaya / John Lazo
Evaluated 12 Mar 2010

DNA damage response to the Mdm2 inhibitor Nutlin-3.
Verma R, Rigatti MJ, …, Godman CA, Giardina C
Biochem Pharmacol 2009 Sep 27 [abstract on PubMed] [related articles] [full text]
Selected by | John Lazo
Evaluated 10 Dec 2009

Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3.
Leeman-Neill RJ, Wheeler SE, …, Johnson DE, Grandis JR
Carcinogenesis 2009 Sep 16 [abstract on PubMed] [related articles] [full text]
Selected by | John Lazo
Evaluated 30 Sep 2009

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Yun SM, Moulaei T, …, Wlodawer A, Lee KS
Nat Struct Mol Biol 2009 Jul 13 [abstract on PubMed] [related articles] [full text]
Selected by | John Lazo
Evaluated 3 Aug 2009

Inappropriate activation of cyclin-dependent kinases by the phosphatase Cdc25b results in premature mitotic entry and triggers a p53-dependent checkpoint.
Varmeh S, Manfredi JJ
J Biol Chem 2009 Apr 3 284(14):9475-88 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo
Evaluated 4 Jun 2009

Autophagy regulates lipid metabolism.
Singh R, Kaushik S, …, Cuervo AM, Czaja MJ
Nature 2009 Apr 30 458(7242):1131-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ray Rodgers / Anthony Means / John Lazo
Evaluated 3 Jun 2009

Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion.
Lee G, White LS, …, Stappenbeck TS, Piwnica-Worms H
Proc Natl Acad Sci U S A 2009 Mar 24 106(12):4701-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo
Evaluated 31 Mar 2009

Identification of stem cells in small intestine and colon by marker gene Lgr5.
Barker N, van Es JH, …, Peters PJ, Clevers H
Nature 2007 Oct 25 449(7165):1003-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Salvador Aznar-Benitah / Matthew John Smalley / Maarten van Lohuizen / Amy Wagers / Leanne Jones / Mariann Bienz / John Lazo
Evaluated 6 Feb 2009


Efficient tumour formation by single human melanoma cells.
Quintana E, Shackleton M, …, Johnson TM, Morrison SJ
Nature 2008 Dec 4 456(7222):593-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ze'ev Ronai / Ruth Roberts / Elda Grabocka and Dafna Bar-Sagi / John Lazo / Lieping Chen
Evaluated 7 Jan 2009


An integrated genomic analysis of human glioblastoma multiforme.
Parsons DW, Jones S, …, Velculescu VE, Kinzler KW
Science 2008 Sep 26 321(5897):1807-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo
Evaluated 15 Oct 2008


A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.
Montagnoli A, Valsasina B, …, Vanotti E, Santocanale C
Nat Chem Biol 2008 Jun 4(6):357-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo
Evaluated 12 Jun 2008

Activation of the cellular DNA damage response in the absence of DNA lesions.
Soutoglou E, Misteli T
Science 2008 Jun 13 320(5882):1507-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo / Yosef Gruenbaum / Sui Huang
Evaluated 12 Jun 2008

Receptor-based virtual ligand screening for the identification of novel CDC25 phosphatase inhibitors.
Montes M, Braud E, …, Garbay C, Villoutreix BO
J Chem Inf Model 2008 Jan 48(1):157-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo
Evaluated 7 Mar 2008

Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3.
Forte E, Orsatti L, …, De Francesco R, Tomei L
Biochim Biophys Acta 2008 Feb 1783(2):334-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo
Evaluated 21 Feb 2008

NanoLC-MS/MS Analysis Provides New Insights into the Phosphorylation Pattern of Cdc25B in Vivo: Full Overlap with Sites of Phosphorylation by Chk1 and Cdk1/cycB Kinases in Vitro.
Bouché JP, Froment C, …, Burlet-Schiltz O, Ducommun B
J Proteome Res 2008 Feb 1 0 [abstract on PubMed] [related articles] [full text]
Selected by | John Lazo
Evaluated 21 Feb 2008

A Selective Phosphatase of Regenerating Liver Phosphatase Inhibitor Suppresses Tumor Cell Anchorage-Independent Growth by a Novel Mechanism Involving p130Cas Cleavage.
Daouti S, Li WH, …, Heimbrook D, Niu H
Cancer Res 2008 Feb 15 68(4):1162-1169 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo
Evaluated 19 Feb 2008

The dual specificity phosphatase Cdc25B, but not the closely related Cdc25C, is capable of inhibiting cellular proliferation in a manner dependent upon its catalytic activity.
Varmeh-Ziaie S, Manfredi JJ
J Biol Chem 2007 Aug 24 282(34):24633-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo
Evaluated 27 Nov 2007

Differential mitotic degradation of the CDC25B phosphatase variants.
Kieffer I, Lorenzo C, …, Schmitt E, Ducommun B
Oncogene 2007 Dec 13 26(57):7847-58 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo
Evaluated 15 Aug 2007

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
Rodina A, Vilenchik M, …, Krystal GW, Chiosis G
Nat Chem Biol 2007 Aug 3(8):498-507 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo / Takashi Tsuruo
Evaluated 2 Aug 2007

MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps.
Kasibhatla S, Baichwal V, …, Carlson RO, Pleiman CM
Cancer Res 2007 Jun 15 67(12):5865-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo
Evaluated 5 Jul 2007

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.
Raynaud FI, Eccles S, …, Waterfield M, Workman P
Cancer Res 2007 Jun 15 67(12):5840-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo
Evaluated 3 Jul 2007

The crystal structure of human cyclin B.
Petri ET, Errico A, …, Hunt T, Basavappa R
Cell Cycle 2007 Jun 6(11):1342-9 [abstract on PubMed] [related articles] [order article]
Selected by | John Lazo
Evaluated 26 Jun 2007

Synthetic lethal screen identification of chemosensitizer loci in cancer cells.
Whitehurst AW, Bodemann BO, …, Xie XJ, White MA
Nature 2007 Apr 12 446(7137):815-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo / Takashi Tsuruo
Evaluated 26 Apr 2007

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
Bartkova J, Rezaei N, …, Bartek J, Gorgoulis VG
Nature 2006 Nov 30 444(7119):633-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael B Yaffe / John Lazo / Lucio Comai
Evaluated 21 Dec 2006

A bacterial protein enhances the release and efficacy of liposomal cancer drugs.
Cheong I, Huang X, …, Zhou S, Vogelstein B
Science 2006 Nov 24 314(5803):1308-11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Lazo / Rudy Juliano / Kishor M Wasan / Francis Szoka
Evaluated 8 Dec 2006

Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases.
Syljuåsen RG, Jensen S, Bartek J, Lukas J
Cancer Res 2006 Nov 1 66(21):10253-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Jackson / John Lazo
Evaluated 8 Dec 2006

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.
Inglese J, Auld DS, …, Zheng W, Austin CP
Proc Natl Acad Sci U S A 2006 Aug 1 103(31):11473-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Lazo / Arthur Christopoulos
Evaluated 7 Aug 2006

High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity.
Thomas JP, Lautermann J, …, Seiler F, Thomale J
Mol Pharmacol 2006 Jul 70(1):23-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Lazo
Evaluated 18 Jul 2006

Inhibition of human tyrosyl-DNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors.
Liao Z, Thibaut L, Jobson A, Pommier Y
Mol Pharmacol 2006 Jul 70(1):366-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Lazo
Evaluated 18 Jul 2006

Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase.
Zimny J, Sikora M, Guranowski A, Jakubowski H
J Biol Chem 2006 Aug 11 281(32):22485-92 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Lazo
Evaluated 14 Jul 2006

Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence.
Rahmouni S, Cerignoli F, …, Jiang W, Mustelin T
Nat Cell Biol 2006 May 8(5):524-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Lazo / Andrius Kazlauskas
Evaluated 13 Jun 2006

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