We are using molecular force measurements to eludicate the structural basis of the mechanical properties of adhesion proteins and the materials that comprise the extracellular matrix. These studies focus on the structure-function relationships of proteins and of biomembranes. Recent work has shown that multidomain adhesion proteins may use multiple domains to undergo homophilic binding with identical proteins on adjacent cells. this was initially demonstrated with cadherin, but we are currently investigating the interactions of NCAM and L1.

Matrix crosslinking forces tumor progression by enhancing integrin signaling. Levental KR, Yu H, …, Gasser DL, Weaver VM Cell 2009 Nov 25 139(5):891-906 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 15 Dec 2009 Regulation of homotypic cell-cell adhesion by branched N-glycosylation of N-cadherin extracellular EC2-3 domains. Guo HB, Johnson H, Randolph M, Pierce M J Biol Chem 2009 Oct 21 [abstract on PubMed] [related articles] [full text] Selected by | Deborah Leckband Evaluated 18 Nov 2009 Overexpression of E-cadherin on melanoma cells inhibits chemokine-promoted invasion involving p190RhoGAP/p120ctn-dependent inactivation of RhoA. Molina-Ortiz I, Bartolomé RA, …, Colo GP, Teixidó J J Biol Chem 2009 Mar 17 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 28 Apr 2009 Stabilization provided by neighboring strands is critical for the mechanical stability of proteins. Sharma D, Feng G, …, Lu H, Li H Biophys J 2008 Jul 3 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 31 Jul 2008 Measuring Diffusion and Binding Kinetics by Contact Area FRAP. Tolentino TP, Wu J, …, Dustin ML, Zhu C Biophys J 2008 Apr 4 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 6 May 2008 How cells tiptoe on adhesive surfaces before sticking. Pierres A, Benoliel AM, Touchard D, Bongrand P Biophys J 2008 May 15 94(10):4114-22 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband / Vivian Tang Evaluated 18 Feb 2008 Extending Bell's model: how force transducer stiffness alters measured unbinding forces and kinetics of molecular complexes. Walton EB, Lee S, Van Vliet KJ Biophys J 2008 Jan 4 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 22 Jan 2008 Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Kaizuka Y, Douglass AD, …, Dustin ML, Vale RD Proc Natl Acad Sci U S A 2007 Dec 18 104(51):20296-301 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 21 Jan 2008 Immediate-early signaling induced by E-cadherin engagement and adhesion. Perez TD, Tamada M, Sheetz MP, Nelson WJ J Biol Chem 2007 Dec 17 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband / Kermit Carraway Evaluated 10 Jan 2008 Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion. Yamada S, Nelson WJ J Cell Biol 2007 Jul 30 178(3):517-27 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband / Kathleen J Green / Jeff Hardin Evaluated 3 Aug 2007 Studies of receptor tyrosine kinase transmembrane domain interactions: the EmEx-FRET method. Merzlyakov M, Chen L, Hristova K J Membr Biol 2007 Feb 215(2-3):93-103 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 3 Aug 2007 Surface-supported bilayers with transmembrane proteins: role of the polymer cushion revisited. Merzlyakov M, Li E, Gitsov I, Hristova K Langmuir 2006 Nov 21 22(24):10145-51 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 13 Dec 2006 Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion molecules. Zhu DM, Dustin ML, Cairo CW, Golan DE Biophys J 2007 Feb 1 92(3):1022-34 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 11 Dec 2006 Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Sawada Y, Tamada M, …, Tanaka S, Sheetz MP Cell 2006 Dec 1 127(5):1015-26 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband / Giulio Gabbiani / Kenneth Yamada / Christopher Turner / Toshihiko Ogura Evaluated 11 Dec 2006 Single-molecule mechanics of mussel adhesion. Lee H, Scherer NF, Messersmith PB Proc Natl Acad Sci U S A 2006 Aug 29 103(35):12999-3003 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 31 Aug 2006 Tracking individual kinesin motors in living cells using single quantum-dot imaging. Courty S, Luccardini C, …, Cappello G, Dahan M Nano Lett 2006 Jul 6(7):1491-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 24 Aug 2006 Anisotropic deformation response of single protein molecules. Dietz H, Berkemeier F, Bertz M, Rief M Proc Natl Acad Sci U S A 2006 Aug 22 103(34):12724-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 21 Aug 2006 Nanodiscs separate chemoreceptor oligomeric states and reveal their signaling properties. Boldog T, Grimme S, …, Sligar SG, Hazelbauer GL Proc Natl Acad Sci U S A 2006 Aug 1 103(31):11509-14 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband / George Ordal Evaluated 21 Aug 2006 N-glycosylation affects the molecular organization and stability of E-cadherin junctions. Liwosz A, Lei T, Kukuruzinska MA J Biol Chem 2006 Aug 11 281(32):23138-49 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband / Kermit Carraway Evaluated 8 Jun 2006 Homophilic interactions between cadherin fragments at the single molecule level: an AFM study. du Roure O, Buguin A, Feracci H, Silberzan P Langmuir 2006 May 9 22(10):4680-4 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 31 May 2006 Dynamic microtubules regulate the local concentration of E-cadherin at cell-cell contacts. Stehbens SJ, Paterson AD, …, Parton RG, Yap AS J Cell Sci 2006 May 1 119(Pt 9):1801-11 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband / Valeri Vasioukhin Evaluated 21 Apr 2006 Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity. Jin M, Song G, …, Wittrup DK, Springer TA Proc Natl Acad Sci U S A 2006 Apr 11 103(15):5758-63 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 13 Apr 2006 Theoretical analysis of single-molecule force spectroscopy experiments: heterogeneity of chemical bonds. Raible M, Evstigneev M, …, Anselmetti D, Reimann P Biophys J 2006 Jun 1 90(11):3851-64 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 11 Apr 2006 Transmembrane helix heterodimerization in lipid bilayers: probing the energetics behind autosomal dominant growth disorders. Merzlyakov M, You M, Li E, Hristova K J Mol Biol 2006 Apr 21 358(1):1-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 5 Apr 2006 Unfolding barriers in bacteriorhodopsin probed from the cytoplasmic and the extracellular side by AFM. Kessler M, Gaub HE Structure 2006 Mar 14(3):521-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Stephen White / Deborah Leckband Evaluated 5 Apr 2006 Neuronal synapse interaction reconstituted between live cells and supported lipid bilayers. Pautot S, Lee H, Isacoff EY, Groves JT Nat Chem Biol 2005 Oct 1(5):283-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 23 Jan 2006 Single-molecule unfolding force distributions reveal a funnel-shaped energy landscape. Schlierf M, Rief M Biophys J 2006 Feb 15 90(4):L33-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 20 Jan 2006 Single-molecule analysis of cadherin-mediated cell-cell adhesion. Panorchan P, Thompson MS, …, Konstantopoulos K, Wirtz D J Cell Sci 2006 Jan 1 119(Pt 1):66-74 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 4 Jan 2006 Multiple stepwise refolding of immunoglobulin domain I27 upon force quench depends on initial conditions. Li MS, Hu CK, Klimov DK, Thirumalai D Proc Natl Acad Sci U S A 2006 Jan 3 103(1):93-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 4 Jan 2006 Regulation of N-cadherin dynamics at neuronal contacts by ligand binding and cytoskeletal coupling. Thoumine O, Lambert M, Mège RM, Choquet D Mol Biol Cell 2006 Feb 17(2):862-75 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 9 Dec 2005 E-cadherin tethered to micropatterned supported lipid bilayers as a model for cell adhesion. Perez TD, Nelson WJ, Boxer SG, Kam L Langmuir 2005 Dec 6 21(25):11963-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 8 Dec 2005 Catch-bond model derived from allostery explains force-activated bacterial adhesion. Thomas W, Forero M, …, Sokurenko E, Vogel V Biophys J 2006 Feb 1 90(3):753-64 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 30 Nov 2005 Two-dimensional kinetics regulation of alphaLbeta2-ICAM-1 interaction by conformational changes of the alphaL-inserted domain. Zhang F, Marcus WD, …, Springer TA, Zhu C J Biol Chem 2005 Dec 23 280(51):42207-18 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 29 Nov 2005 Effect of average phospholipid curvature on supported bilayer formation on glass by vesicle fusion. Hamai C, Yang T, …, Cremer PS, Musser SM Biophys J 2006 Feb 15 90(4):1241-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 28 Nov 2005 Altered TCR signaling from geometrically repatterned immunological synapses. Mossman KD, Campi G, Groves JT, Dustin ML Science 2005 Nov 18 310(5751):1191-3 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerald Spangrude / Deborah Leckband / James Crowe / David Margulies / Nicholas Restifo Evaluated 23 Nov 2005 Degree of polymerization (DP) of polysialic acid (polySia) on neural cell adhesion molecules (N-CAMS): development and application of a new strategy to accurately determine the DP of polySia chains on N-CAMS. Nakata D, Troy FA J Biol Chem 2005 Nov 18 280(46):38305-16 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 26 Sep 2005 Cadherin adhesion depends on a salt bridge at the N-terminus. Harrison OJ, Corps EM, Kilshaw PJ J Cell Sci 2005 Sep 15 118(Pt 18):4123-30 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 26 Sep 2005 Sacrificial bonds in polymer brushes from rat tail tendon functioning as nanoscale velcro. Gutsmann T, Hassenkam T, Cutroni JA, Hansma PK Biophys J 2005 Jul 89(1):536-42 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 13 Jun 2005 Unfolding a linker between helical repeats. Ortiz V, Nielsen SO, Klein ML, Discher DE J Mol Biol 2005 Jun 10 349(3):638-47 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 3 Jun 2005 Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines. Shamri R, Grabovsky V, …, von Andrian UH, Alon R Nat Immunol 2005 May 6(5):497-506 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Eric Long / Deborah Leckband Evaluated 31 May 2005 Direct measurement of protein energy landscape roughness. Nevo R, Brumfeld V, …, Hinterdorfer P, Reich Z EMBO Rep 2005 Apr 22 [abstract on PubMed] [related articles] Selected by | Deborah Leckband Evaluated 28 Apr 2005 Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Kirchner C, Liedl T, …, Fertig N, Parak WJ Nano Lett 2005 Feb 5(2):331-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband / Vincent Rotello Evaluated 15 Apr 2005 Simultaneous, coincident optical trapping and single-molecule fluorescence. Lang MJ, Fordyce PM, …, Neuman KC, Block SM Nat Methods 2004 Nov 1(2):133-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Richard Willson / Deborah Leckband Evaluated 13 Apr 2005 Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in vivo and in vitro investigations. Miao H, Hu YL, …, Usami S, Chien S J Vasc Res 2005 Jan-Feb 42(1):77-89 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 3 Mar 2005 Dynamics of unbinding of cell adhesion molecules: transition from catch to slip bonds. Barsegov V, Thirumalai D Proc Natl Acad Sci U S A 2005 Feb 8 102(6):1835-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 23 Feb 2005 Printed covalent glycan array for ligand profiling of diverse glycan binding proteins. Blixt O, Head S, …, Wong CH, Paulson JC Proc Natl Acad Sci U S A 2004 Dec 7 101(49):17033-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 19 Jan 2005 Neurite extension and in vitro myelination within three-dimensional modified fibrin matrices. Pittier R, Sauthier F, Hubbell JA, Hall H J Neurobiol 2005 Apr 63(1):1-14 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 6 Jan 2005 Adhesion-contractile balance in myocyte differentiation. Griffin MA, Sen S, Sweeney HL, Discher DE J Cell Sci 2004 Nov 15 117(Pt 24):5855-63 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 8 Dec 2004 Trans-bonded pairs of E-cadherin exhibit a remarkable hierarchy of mechanical strengths. Perret E, Leung A, Feracci H, Evans E Proc Natl Acad Sci U S A 2004 Nov 23 101(47):16472-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 24 Nov 2004 Surface mechanics mediate pattern formation in the developing retina. Hayashi T, Carthew RW Nature 2004 Oct 7 431(7009):647-52 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband / Talila Volk / Marta Llimargas / Buzz Baum / Jennifer Fletcher / Jeffrey Axelrod / Carien Niessen / Ross Cagan / David Bilder Evaluated 13 Oct 2004 Growth cones turn and migrate up an immobilized gradient of the laminin IKVAV peptide. Adams DN, Kao EY, …, Hu WS, Letourneau PC J Neurobiol 2005 Jan 62(1):134-47 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 5 Oct 2004 Hydrodynamic effects in fast AFM single-molecule force measurements. Janovjak H, Struckmeier J, Müller DJ Eur Biophys J 2005 Feb 34(1):91-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 16 Aug 2004 Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond. Evans E, Leung A, Heinrich V, Zhu C Proc Natl Acad Sci U S A 2004 Aug 3 101(31):11281-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband / Klaus Ley Evaluated 13 Aug 2004 Histamine selectively interrupts VE-cadherin adhesion independently of capacitive calcium entry. Winter MC, Shasby SS, Ries DR, Shasby DM Am J Physiol Lung Cell Mol Physiol 2004 Oct 287(4):L816-23 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 7 Jul 2004 Carbohydrate-carbohydrate interaction provides adhesion force and specificity for cellular recognition. Bucior I, Scheuring S, Engel A, Burger MM J Cell Biol 2004 May 24 165(4):529-37 [abstract on PubMed] [related articles] [FREE full text] Selected by | Sheila McCormick / John Couchman / Deborah Leckband Evaluated 30 Jun 2004 Toward immobilized antibody microarray optimization: print buffer and storage condition comparisons on performance. Wu P, Grainger DW Biomed Sci Instrum 2004 40:243-8 [abstract on PubMed] [related articles] [order article] Selected by | Deborah Leckband Evaluated 30 Jun 2004 Mechanotransduction through growth-factor shedding into the extracellular space. Tschumperlin DJ, Dai G, …, Kamm RD, Drazen JM Nature 2004 May 6 429(6987):83-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband / Marcos Gonzalez-Gaitan / Manfred Schliwa Evaluated 30 Apr 2004 Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography. Häussinger D, Ahrens T, …, Stetefeld J, Grzesiek S EMBO J 2004 Apr 21 23(8):1699-708 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 27 Apr 2004 Molecular dissection of the ST8Sia IV polysialyltransferase. Distinct domains are required for neural cell adhesion molecule recognition and polysialylation. Angata K, Chan D, Thibault J, Fukuda M J Biol Chem 2004 Jun 11 279(24):25883-90 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 27 Apr 2004 A soluble VE-cadherin fragment forms 2D arrays of dimers upon binding to a lipid monolayer. Al-Kurdi R, Gulino-Debrac D, …, Hewat E, Vénien-Bryan C J Mol Biol 2004 Apr 2 337(4):881-92 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 13 Apr 2004 cis-Dimer formation of E-cadherin is independent of cell-cell adhesion assembly in vivo. Takeda H Biochem Biophys Res Commun 2004 Apr 9 316(3):822-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 13 Apr 2004 Distinct roles of different neural cell adhesion molecule (NCAM) isoforms in synaptic maturation revealed by analysis of NCAM 180 kDa isoform-deficient mice. Polo-Parada L, Bose CM, Plattner F, Landmesser LT J Neurosci 2004 Feb 25 24(8):1852-64 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 24 Mar 2004 Structure and dynamics of supported intermembrane junctions. Kaizuka Y, Groves JT Biophys J 2004 Feb 86(2):905-12 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 22 Mar 2004 Combined optical trapping and single-molecule fluorescence. Lang MJ, Fordyce PM, Block SM J Biol 2003 2(1):6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband / Peter Qin Evaluated 12 Jun 2003 Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics. Lutolf MP, Lauer-Fields JL, …, Fields GB, Hubbell JA Proc Natl Acad Sci U S A 2003 Apr 29 100(9):5413-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ross Weatherman / Deborah Leckband Evaluated 27 May 2003 A synthetic peptide ligand of neural cell adhesion molecule (NCAM), C3d, promotes neuritogenesis and synaptogenesis and modulates presynaptic function in primary cultures of rat hippocampal neurons. Kiryushko D, Kofoed T, …, Berezin V, Bock E J Biol Chem 2003 Apr 4 278(14):12325-34 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 27 May 2003 DNA unzipped under a constant force exhibits multiple metastable intermediates. Danilowicz C, Coljee VW, …, Nelson DR, Prentiss M Proc Natl Acad Sci U S A 2003 Feb 18 100(4):1694-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 14 Feb 2003 Relating single-molecule measurements to thermodynamics. Keller D, Swigon D, Bustamante C Biophys J 2003 Feb 84(2 Pt 1):733-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 14 Feb 2003 Sugar-coated microarrays: a novel slide surface for the high-throughput analysis of glycans. Willats WG, Rasmussen SE, …, Mikkelsen JD, Knox JP Proteomics 2002 Dec 2(12):1666-71 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Deborah Leckband Evaluated 13 Jan 2003 Calcium-dependent homoassociation of E-cadherin by NMR spectroscopy: changes in mobility, conformation and mapping of contact regions. Häussinger D, Ahrens T, …, Engel J, Grzesiek S J Mol Biol 2002 Dec 6 324(4):823-39 [abstract on PubMed] [related articles] [order article] Selected by | Deborah Leckband Evaluated 9 Jan 2003 Targeting axons to specific fiber tracts in vivo by altering cadherin expression. Treubert-Zimmermann U, Heyers D, Redies C J Neurosci 2002 Sep 1 22(17):7617-26 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 30 Sep 2002 Force spectroscopy of the leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. Zhang X, Wojcikiewicz E, Moy VT Biophys J 2002 Oct 83(4):2270-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 30 Sep 2002 In the first extracellular domain of E-cadherin, heterophilic interactions, but not the conserved His-Ala-Val motif, are required for adhesion. Renaud-Young M, Gallin WJ J Biol Chem 2002 Oct 18 277(42):39609-16 [abstract on PubMed] [related articles] [FREE full text] Selected by | Vance Lemmon / Deborah Leckband Evaluated 13 Sep 2002 Optical interference artifacts in contact atomic force microscopy images. Méndez-Vilas A, González-Martin ML, Nuevo MJ Ultramicroscopy 2002 Aug 92(3-4):243-50 [abstract on PubMed] [related articles] [order article] Selected by | Deborah Leckband Evaluated 10 Sep 2002 Dynamic response of adhesion complexes: beyond the single-path picture. Bartolo D, Derényi I, Ajdari A Phys Rev E Stat Nonlin Soft Matter Phys 2002 May 65(5 Pt 1):051910 [abstract on PubMed] [related articles] [order article] Selected by | Deborah Leckband Evaluated 10 Jul 2002 Single-molecule optomechanical cycle. Hugel T, Holland NB, …, Seitz M, Gaub HE Science 2002 May 10 296(5570):1103-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 11 Jun 2002 Probing protein electrostatics with a synthetic fluorescent amino acid. Cohen BE, McAnaney TB, …, Boxer SG, Jan LY Science 2002 May 31 296(5573):1700-3 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband / Peter Qin / Yu-Li Wang / Volkhard Helms / Arieh Warshel / Mario Amzel / Ross Weatherman / Robert Kelley Evaluated 11 Jun 2002 Endothelial chemokines destabilize L-selectin-mediated lymphocyte rolling without inducing selectin shedding. Grabovsky V, Dwir O, Alon R J Biol Chem 2002 Jun 7 277(23):20640-50 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 10 Jun 2002 Protein nanoarrays generated by dip-pen nanolithography. Lee KB, Park SJ, …, Smith JC, Mrksich M Science 2002 Mar 1 295(5560):1702-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 13 Feb 2002 A small-molecule modulator of poly-alpha 2,8-sialic acid expression on cultured neurons and tumor cells. Mahal LK, Charter NW, …, Koshland DE, Bertozzi CR Science 2001 Oct 12 294(5541):380-1 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ross Weatherman / Deborah Leckband / Genevieve Rougon Evaluated 29 Nov 2001 Kinetics of membrane adhesion mediated by ligand-receptor interaction studied with a biomimetic system. Boulbitch A, Guttenberg Z, Sackmann E Biophys J 2001 Nov 81(5):2743-51 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 29 Nov 2001 Multiple conformations of PEVK proteins detected by single-molecule techniques. Li H, Oberhauser AF, …, Erickson HP, Fernandez JM Proc Natl Acad Sci U S A 2001 Sep 11 98(19):10682-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Deborah Leckband Evaluated 27 Nov 2001

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