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Arthur Mercurio
University of Massachusetts Medical School , United States of America

Faculty Member: Cell Biology > Cell Adhesion [ since 24 October 2002 ]
[ Evaluations ]
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Evaluations

Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development.
Lichtenberger BM, Tan PK, …, Petzelbauer P, Sibilia M
Cell 2010 Jan 22 140(2):268-79 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio
Evaluated 15 Mar 2010

RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.
Doehn U, Hauge C, …, Hansen SH, Frödin M
Mol Cell 2009 Aug 28 35(4):511-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Simon Cook / Arthur Mercurio
Evaluated 6 Jan 2010

Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche.
Erler JT, Bennewith KL, …, Le QT, Giaccia AJ
Cancer Cell 2009 Jan 6 15(1):35-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio
Evaluated 2 Nov 2009

Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion.
Wu Y, Deng J, …, Evers BM, Zhou BP
Cancer Cell 2009 May 5 15(5):416-28 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jean Pieters / Arthur Mercurio / Avri Ben-Ze'ev
Evaluated 17 Jul 2009

Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.
Valdembri D, Caswell PT, …, Bussolino F, Serini G
PLoS Biol 2009 Jan 27 7(1):e25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard Klemke / Arthur Mercurio
Evaluated 22 Apr 2009

Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells.
Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y
Cancer Cell 2009 Mar 3 15(3):195-206 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio / M. Angela Nieto
Evaluated 12 Mar 2009

NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin.
Lehembre F, Yilmaz M, …, Jonkers J, Christofori G
EMBO J 2008 Oct 8 27(19):2603-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio
Evaluated 11 Dec 2008

Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence.
Ansieau S, Bastid J, …, Caron de Fromentel C, Puisieux A
Cancer Cell 2008 Jul 8 14(1):79-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Avri Ben-Ze'ev / Arthur Mercurio
Evaluated 7 Oct 2008

Regulation of epithelial branching morphogenesis and cancer cell growth of the prostate by Wnt signaling.
Wang BE, Wang XD, …, Polakis P, Gao WQ
PLoS ONE 2008 3(5):e2186 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Mercurio
Evaluated 3 Sep 2008

Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins.
Haraguchi M, Okubo T, …, McHugh KP, Ozawa M
J Biol Chem 2008 Jun 30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Mercurio
Evaluated 21 Jul 2008

The epithelial-mesenchymal transition generates cells with properties of stem cells.
Mani SA, Guo W, …, Yang J, Weinberg RA
Cell 2008 May 16 133(4):704-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Avri Ben-Ze'ev / Arthur Mercurio / Heather Lee and Christopher Ormandy / David Bilder
Evaluated 9 Jun 2008


The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.
Park SM, Gaur AB, Lengyel E, Peter ME
Genes Dev 2008 Apr 1 22(7):894-907 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio
Evaluated 11 Apr 2008

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
Gregory PA, Bert AG, …, Khew-Goodall Y, Goodall GJ
Nat Cell Biol 2008 Mar 30 [abstract on PubMed] [related articles] [full text]
Selected by | Arthur Mercurio
Evaluated 11 Apr 2008

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.
Leong KG, Niessen K, …, Pollet I, Karsan A
J Exp Med 2007 Nov 26 204(12):2935-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio
Evaluated 6 Mar 2008

The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis.
Huang Q, Gumireddy K, …, Puré E, Agami R
Nat Cell Biol 2008 Feb 10(2):202-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio
Evaluated 3 Mar 2008

Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition.
Acevedo VD, Gangula RD, …, Ittmann M, Spencer DM
Cancer Cell 2007 Dec 12(6):559-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio
Evaluated 1 Feb 2008

RNA-binding IMPs promote cell adhesion and invadopodia formation.
Vikesaa J, Hansen TV, …, Christiansen J, Nielsen FC
EMBO J 2006 Apr 5 25(7):1456-68 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Filippo Giancotti / Arthur Mercurio
Evaluated 28 Nov 2007

Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway.
Lamouille S, Derynck R
J Cell Biol 2007 Jul 30 178(3):437-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio
Evaluated 22 Oct 2007

Caspase proteolysis of the integrin beta4 subunit disrupts hemidesmosome assembly, promotes apoptosis, and inhibits cell migration.
Werner ME, Chen F, …, Jones JC, Cryns VL
J Biol Chem 2007 Feb 23 282(8):5560-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio
Evaluated 12 Sep 2007

Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development.
Sakai D, Suzuki T, Osumi N, Wakamatsu Y
Development 2006 Apr 133(7):1323-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Mercurio
Evaluated 12 Jul 2007

Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis.
Zaman MH, Trapani LM, …, Lauffenburger DA, Matsudaira P
Proc Natl Acad Sci U S A 2006 Jul 18 103(29):10889-94 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alan Rick Horwitz / Arthur Mercurio
Evaluated 4 Jan 2007

p63 regulates an adhesion programme and cell survival in epithelial cells.
Carroll DK, Carroll JS, …, Brugge JS, Ellisen LW
Nat Cell Biol 2006 Jun 8(6):551-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio
Evaluated 26 Oct 2006

Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling.
Shintani Y, Takashima S, …, Kitakaze M, Hori M
EMBO J 2006 Jul 12 25(13):3045-55 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Mercurio
Evaluated 1 Aug 2006

Lysyl oxidase is essential for hypoxia-induced metastasis.
Erler JT, Bennewith KL, …, Jeffrey SS, Giaccia AJ
Nature 2006 Apr 27 440(7088):1222-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Abraham / Arthur Mercurio
Evaluated 31 May 2006


Chemical genetic analysis of the time course of signal transduction by JNK.
Ventura JJ, Hübner A, …, Shokat KM, Davis RJ
Mol Cell 2006 Mar 3 21(5):701-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio / Francesc Posas
Evaluated 28 Mar 2006

Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT.
Yoeli-Lerner M, Yiu GK, …, Jauliac S, Toker A
Mol Cell 2005 Nov 23 20(4):539-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio
Evaluated 25 Jan 2006

Integrin-dependent actomyosin contraction regulates epithelial cell scattering.
de Rooij J, Kerstens A, …, Schwartz MA, Waterman-Storer CM
J Cell Biol 2005 Oct 10 171(1):153-64 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Mercurio / Kenneth Yamada / Dietmar Vestweber / Dorit Hanein
Evaluated 31 Oct 2005

Beta4 integrin subunit gene expression correlates with tumor size and nuclear grade in early breast cancer.
Diaz LK, Cristofanilli M, …, Sahin AA, Gilcrease MZ
Mod Pathol 2005 Sep 18(9):1165-75 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Mercurio
Evaluated 21 Jul 2005

Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse.
Liebner S, Cattelino A, …, Piccolo S, Dejana E
J Cell Biol 2004 Aug 2 166(3):359-67 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Mercurio
Evaluated 19 Apr 2005

Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes.
Rajasekhar VK, Viale A, …, Hu X, Holland EC
Mol Cell 2003 Oct 12(4):889-901 [abstract on PubMed] [related articles] [order article]
Selected by | Chandra Kumar / Arthur Mercurio
Evaluated 29 Oct 2004

A dynamic podosome-like structure of epithelial cells.
Spinardi L, Rietdorf J, …, Way M, Marchisio PC
Exp Cell Res 2004 May 1 295(2):360-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Mercurio
Evaluated 26 Jul 2004

The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration.
Santoro MM, Gaudino G, Marchisio PC
Dev Cell 2003 Aug 5(2):257-71 [abstract on PubMed] [related articles] [order article]
Selected by | Filippo Giancotti / Arthur Mercurio
Evaluated 26 Feb 2004

Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin.
Russell AJ, Fincher EF, …, Weaver VM, Marinkovich MP
J Cell Sci 2003 Sep 1 116(Pt 17):3543-56 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Mercurio
Evaluated 9 Oct 2003

NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.
Dajee M, Lazarov M, …, Kubo Y, Khavari PA
Nature 2003 Feb 6 421(6923):639-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Charles Streuli / Jean Schwarzbauer / Arthur Mercurio / Channing Der
Evaluated 13 Mar 2003

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