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David Kranz
The School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, United States of America

Faculty Member: Immunology > Antigen Processing & Recognition [ since 8 February 2006 ]
[ Evaluations ]
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Evaluations

A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire.
Wang B, Primeau TM, …, Hansen TH, Connolly JM
Science 2009 Nov 6 326(5954):871-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Edward Collins / David Kranz
Evaluated 23 Dec 2009

Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation.
Marks BR, Nowyhed HN, …, Flavell RA, Craft J
Nat Immunol 2009 Oct 10(10):1125-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz / Paul Gleeson / Thomas Hunig
Evaluated 5 Oct 2009

Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen.
Velikovsky CA, Deng L, …, Pancer Z, Mariuzza RA
Nat Struct Mol Biol 2009 Jun 21 16 [abstract on PubMed] [related articles] [full text]
Selected by | David Kranz
Evaluated 10 Jul 2009

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
Beddoe T, Chen Z, …, McCluskey J, Rossjohn J
Immunity 2009 Jun 19 30(6):777-88 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jennifer D. Stone and David Kranz / Stanley Perlman
Evaluated 3 Jun 2009

Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease.
Delgado MF, Coviello S, …, Irusta PM, Polack FP
Nat Med 2009 Jan 15(1):34-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jennifer D Stone and David Kranz / Richard Vile / Dale Umetsu
Evaluated 19 Jan 2009


Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice.
Bai A, Higham E, …, Wittrup KD, Chen J
Proc Natl Acad Sci U S A 2008 Sep 2 105(35):13003-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Kranz
Evaluated 10 Sep 2008

Specificity in cancer immunotherapy.
Schietinger A, Philip M, Schreiber H
Semin Immunol 2008 Aug 4 [abstract on PubMed] [related articles] [full text]
Selected by | David Kranz
Evaluated 4 Sep 2008

Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness.
Willimsky G, Czéh M, …, Stein H, Blankenstein T
J Exp Med 2008 Jul 7 205(7):1687-700 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jennifer D. Stone and David Kranz
Evaluated 25 Jul 2008

Vaccine adjuvants alter TCR-based selection thresholds.
Malherbe L, Mark L, …, McHeyzer-Williams LJ, McHeyzer-Williams MG
Immunity 2008 May 28(5):698-709 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz / Luc Teyton / Marcia Blackman / Andrea Sant
Evaluated 8 May 2008

Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes.
Demotte N, Stroobant V, …, Boon T, van der Bruggen P
Immunity 2008 Mar 28(3):414-24 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz
Evaluated 25 Mar 2008


Intracellular interaction of IL-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity.
Bergamaschi C, Rosati M, …, Felber BK, Pavlakis GN
J Biol Chem 2007 Nov 30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Kranz
Evaluated 14 Jan 2008

Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.
Van Laethem F, Sarafova SD, …, Feigenbaum L, Singer A
Immunity 2007 Nov 27(5):735-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz / Edward Collins
Evaluated 6 Dec 2007

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.
Park JH, Adoro S, …, Feigenbaum L, Singer A
Nat Immunol 2007 Oct 8(10):1049-59 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz / Ed Palmer
Evaluated 4 Oct 2007

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.
Moon JJ, Chu HH, …, Kedl RM, Jenkins MK
Immunity 2007 Aug 27(2):203-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Leo Lefrancois / Andrea Sant / David Kranz / Christian Engwerda
Evaluated 10 Sep 2007

Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells.
Shojaei F, Wu X, …, Gerber HP, Ferrara N
Nat Biotechnol 2007 Aug 25(8):911-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz / Robert Kerbel
Evaluated 3 Aug 2007

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.
Chen CJ, Kono H, …, Akira S, Rock KL
Nat Med 2007 Jul 13(7):851-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz / Grant McFadden / Klaus Ley
Evaluated 21 Jun 2007


The immunoglobulin heavy chain constant region affects kinetic and thermodynamic parameters of antibody variable region interactions with antigen.
Torres M, Fernández-Fuentes N, Fiser A, Casadevall A
J Biol Chem 2007 May 4 282(18):13917-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz
Evaluated 9 May 2007

Beyond dimerization: a membrane-dependent activation model for interleukin-4 receptor-mediated signalling.
Weidemann T, Höfinger S, Müller K, Auer M
J Mol Biol 2007 Mar 9 366(5):1365-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz / Ralf Jockers
Evaluated 16 Feb 2007

Antibody buffering in the brain.
O'Hear C, Foote J
J Mol Biol 2006 Dec 15 364(5):1003-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz
Evaluated 29 Nov 2006

Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection.
Brown IE, Blank C, …, Kacha AK, Gajewski TF
J Immunol 2006 Oct 1 177(7):4521-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Kranz
Evaluated 11 Oct 2006

Early immunization induces persistent tumor-infiltrating CD8+ T cells against an immunodominant epitope and promotes lifelong control of pancreatic tumor progression in SV40 tumor antigen transgenic mice.
Otahal P, Schell TD, …, Knowles BB, Tevethia SS
J Immunol 2006 Sep 1 177(5):3089-99 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Kranz
Evaluated 13 Sep 2006

The clone size of peripheral CD8 T cells is regulated by TCR promiscuity.
Hao Y, Legrand N, Freitas AA
J Exp Med 2006 Jul 10 203(7):1643-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Kranz
Evaluated 31 Jul 2006

A liposome-PCR assay for the ultrasensitive detection of biological toxins.
Mason JT, Xu L, Sheng ZM, O'Leary TJ
Nat Biotechnol 2006 May 24(5):555-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz
Evaluated 12 Jun 2006

Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response.
Sethi DK, Agarwal A, …, Rao KV, Salunke DM
Immunity 2006 Apr 24(4):429-38 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz
Evaluated 2 May 2006

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires.
Hsieh CS, Zheng Y, …, Fontenot JD, Rudensky AY
Nat Immunol 2006 Apr 7(4):401-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz / Elizabeth Mellins
Evaluated 5 Apr 2006

Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation.
Kim YM, Pan JY, …, Boes M, Ploegh HL
Proc Natl Acad Sci U S A 2006 Feb 28 103(9):3327-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Kranz / Marcus Clark
Evaluated 8 Mar 2006

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