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Ruth Roberts
Safety Assessment UK, AstraZeneca, United Kingdom
Faculty Member: Pharmacology & Drug Discovery > Toxicology [ since 28 June 2006 ]
[
Evaluations
]
selected articles
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Evaluations
Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation.
Zheng W, Xin N, …, Li JY, Wang ZY
FASEB J
2009 Dec
23
(12):4207-17 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Tamara Nicolson and Ruth Roberts
Evaluated 13 Jan 2010
Identification of compounds selectively killing multidrug-resistant cancer cells.
Türk D, Hall MD, …, Gottesman MM, Szakács G
Cancer Res
2009 Nov 1
69
(21):8293-301 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Howard Mellor and Ruth Roberts
Evaluated 7 Dec 2009
Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes.
Rachek LI, Yuzefovych LV, …, Julie NL, Wilson GL
Toxicol Appl Pharmacol
2009 Nov 1
240
(3):348-54 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Tamara Nicholson and Ruth Roberts
Evaluated 7 Dec 2009
Hemangiosarcoma in rodents: mode-of-action evaluation and human relevance.
Cohen SM, Storer RD, …, Swenberg JA, Cook JC
Toxicol Sci
2009 Sep
111
(1):4-18 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Howard Mellor and Ruth Roberts
Evaluated 6 Nov 2009
Expression levels of pituitary tumor transforming 1 and glutathione-S-tranferase theta 3 are associated with the individual susceptibility to D-galactosamine-induced hepatotoxicity.
Yun JW, Kim CW, …, Lim KM, Kang KS
Toxicol Appl Pharmacol
2009 Oct 1 [
abstract on PubMed
] [
related articles
] [
full text
]
Selected by
| Tamara Nicolson and Ruth Roberts
Evaluated 9 Oct 2009
Two types of dopamine neuron distinctly convey positive and negative motivational signals.
Matsumoto M, Hikosaka O
Nature
2009 Jun 11
459
(7248):837-41 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Kent Berridge / Michael Frank and James Surmeier / Ruth Roberts
Evaluated 29 Jul 2009
Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes.
Ashley AK, Hanneman WH, …, Tjalkens RB, Legare ME
Toxicol Lett
2009 Feb 10
184
(3):186-91 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Ruth Roberts
Evaluated 26 Feb 2009
Efficient tumour formation by single human melanoma cells.
Quintana E, Shackleton M, …, Johnson TM, Morrison SJ
Nature
2008 Dec 4
456
(7222):593-8 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Ze'ev Ronai / Ruth Roberts / Elda Grabocka and Dafna Bar-Sagi / John Lazo / Lieping Chen
Evaluated 2 Jan 2009
Increased pancreatic beta-cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria.
Bruin JE, Gerstein HC, Morrison KM, Holloway AC
Toxicol Sci
2008 Jun
103
(2):362-70 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Ruth Roberts
Evaluated 23 May 2008
The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha.
Yang Q, Nagano T, …, Ito S, Gonzalez FJ
Toxicol Sci
2008 Jan
101
(1):132-9 [
abstract on PubMed
] [
related articles
] [
FREE full text
]
Selected by
| Ruth Roberts
Evaluated 10 Mar 2008
The complexities of air pollution regulation: the need for an integrated research and regulatory perspective.
Nadadur SS, Miller CA, …, Vandenberg JJ, Costa DL
Toxicol Sci
2007 Dec
100
(2):318-27 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Ruth Roberts
Evaluated 30 Jan 2008
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.
Cunningham JT, Rodgers JT, …, Mootha VK, Puigserver P
Nature
2007 Nov 29
450
(7170):736-40 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Markus Ruegg / Ruth Roberts
Evaluated 13 Dec 2007
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.
Li X, Monks B, Ge Q, Birnbaum MJ
Nature
2007 Jun 21
447
(7147):1012-6 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Ruth Roberts
Evaluated 21 Sep 2007
Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhage.
Hsieh YC, Frink M, …, Bland KI, Chaudry IH
J Cell Physiol
2007 May
211
(2):364-70 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Ruth Roberts
Evaluated 4 Jul 2007
In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells.
Davoren M, Herzog E, …, Byrne HJ, Lyng FM
Toxicol In Vitro
2007 Apr
21
(3):438-48 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Ruth Roberts
Evaluated 10 May 2007
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis.
Zheng Y, Danilenko DM, …, Wu J, Ouyang W
Nature
2007 Feb 8
445
(7128):648-51 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Steve Ward / Steven Rosenberg / Ruth Roberts / James Campbell
Evaluated 21 Mar 2007
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3.
Sergina NV, Rausch M, …, Shokat KM, Moasser MM
Nature
2007 Jan 25
445
(7126):437-41 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Robert Abraham / Ruth Roberts / Len Neckers / Karen Anderson
Evaluated 7 Feb 2007
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.
Gilchrist M, Thorsson V, …, Bolouri H, Aderem A
Nature
2006 May 11
441
(7090):173-8 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Raymond Mejia / Andrew D Sharrocks / David Underhill / Ruth Roberts
Evaluated 22 Sep 2006
Manganese suppresses ATP-dependent intercellular calcium waves in astrocyte networks through alteration of mitochondrial and endoplasmic reticulum calcium dynamics.
Tjalkens RB, Zoran MJ, Mohl B, Barhoumi R
Brain Res
2006 Oct 3
1113
(1):210-9 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Ruth Roberts
Evaluated 22 Sep 2006
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