 | Paula Sundstrom
Department of Microbiology and Immunology, Dartmouth Medical school, Hanover, United States of America | | | Faculty Member: Microbiology > Cellular Microbiology & Pathogenesis [ since 19 September 2002 ] |
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Dr. Sundstrom received her B.A. degree from Pomona College in Claremont, California in 1974 majoring in Biochemistry. Dr. Sundstrom obtained MT(ASCP) certification at the Santa Monica Hospital and Medical Center specializing in Medical Microbiology. She received M.S. and Ph.D degrees in 1979 and 1986, respectively, from the University of Washington, where she developed methods to study and identify proteins that are induced during bud-hypha transitions of Candida albicans and are important for virulence. In 1986, Dr. Sundstrom moved to the University of California at Irvine where she was awarded a Bank of America Gianinni Foundation Fellowship in Medical Research and investigated the role of elongation factor 1a in fungal morphogenesis. In 1989, Dr. Sundstrom initiated an independent, externally funded research program at the Microbiology and Immunology Department at the University of North Texas Health Sciences Center in Fort Worth. In 1994 she moved to the College of Medicine and Public Health at The Ohio State University where she became an Associate Professor in 1995. She moved to Dartmouth Medical School in the Fall of 2003. In 2000 Dr. Sundstrom received a Scholar Award in Molecular Pathogenic Mycology from the Burroughs Wellcome Foundation.
Understanding molecular mechanisms of pathogenesis that are particular to fungi is the research focus in Dr. Sundstrom's laboratory. Investigators study the most frequent fungal pathogen of man, Candida albicans, which employs morphological transitions to drive changes in gene expression that are important for virulence. Several projects are currently being addressed including: a novel mechanism of covalent adhesion to stratified squamous epithelial cells through a hypha-specific surface protein Hwp1, regulation of expression of the HWP1 gene, identification of virulence factors that are co-regulated with HWP1, development of tools for studying gene expression in Candida albicans and the role of the cAMP pathway in modulating morphogenic transitions. For more information on research in Dr. Sundstrom's laboratory, please visit The Sundstrom Lab website. | Home page
http://www.dartmouth.edu/~sundstrom/ |
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