homefeedbacksupportlog on 21-Mar-2010 
  About F1000

 What is F1000?
 Key features
 How it's organized
 FAQs
 Faculties and sections
 Scope of sections
 Intl Advisory Board
 List of Faculty Members
 Associate Faculty Members
 The evaluation system
 Citing F1000
 Take a tour of the site
 Accessing fulltexts
 PubMed linkout
 How to subscribe
 Academic subscriptions
 Corporate subscriptions
 Try F1000 for free
 Who we are
 Media information
 Librarian resources
 Press releases
 In the press
 Developing countries
 F1000 Medicine
 Terms and conditions
 Privacy policy
 Contact us


Stuart S Licht
Novartis Institutes for Biomedical Research, Cambridge, United States of America

Faculty Member: Chemical Biology > Biocatalysis [ since 7 August 2003 ]
[ Evaluations ]
to email [Help]
Evaluations

Learning rates and states from biophysical time series: a Bayesian approach to model selection and single-molecule FRET data.
Bronson JE, Fei J, …, Gonzalez RL, Wiggins CH
Biophys J 2009 Dec 16 97:3196-205 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S Licht
Evaluated 8 Mar 2010

Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling.
Rodgers MA, Saghatelian A, Yang PL
J Am Chem Soc 2009 Apr 15 131(14):5030-1 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S Licht
Evaluated 6 Jan 2010

A genetically encoded fluorescent reporter of ATP:ADP ratio.
Berg J, Hung YP, Yellen G
Nat Methods 2009 Feb 6(2):161-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Surmeier / Stuart S Licht
Evaluated 7 Sep 2009

High-throughput thermal scanning: a general, rapid dye-binding thermal shift screen for protein engineering.
Lavinder JJ, Hari SB, Sullivan BJ, Magliery TJ
J Am Chem Soc 2009 Mar 25 131(11):3794-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S Licht
Evaluated 26 May 2009

Mechanism-based small molecule probes for labeling CD38 on live cells.
Jiang H, Congleton J, …, Yen A, Lin H
J Am Chem Soc 2009 Feb 11 131(5):1658-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S. Licht
Evaluated 4 Mar 2009

Nanoscale imaging of molecular positions and anisotropies.
Gould TJ, Gunewardene MS, …, Gosse JA, Hess ST
Nat Methods 2008 Dec 5(12):1027-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S. Licht
Evaluated 5 Jan 2009

Dissecting enzyme regulation by multiple allosteric effectors: nucleotide regulation of aspartate transcarbamoylase.
Rabinowitz JD, Hsiao JJ, …, Li G, Rabitz H
Biochemistry 2008 May 27 47(21):5881-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S. Licht
Evaluated 18 Aug 2008

Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system.
Macdonald JL, Pike LJ
Proc Natl Acad Sci U S A 2008 Jan 8 105(1):112-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S. Licht
Evaluated 18 Aug 2008

Distinct and Long-Lived Activity States of Single Enzyme Molecules.
Rissin DM, Gorris HH, Walt DR
J Am Chem Soc 2008 Mar 5 [abstract on PubMed] [related articles] [full text]
Selected by | Stuart S. Licht
Evaluated 7 Apr 2008

Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel.
Sadovsky E, Yifrach O
Proc Natl Acad Sci U S A 2007 Dec 11 104(50):19813-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S. Licht
Evaluated 8 Jan 2008

Do ligand binding and solvent exclusion alter the electrostatic character within the oxyanion hole of an enzymatic active site?
Sigala PA, Fafarman AT, …, Boxer SG, Herschlag D
J Am Chem Soc 2007 Oct 10 129(40):12104-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rowena Matthews / Stuart S. Licht
Evaluated 16 Oct 2007

Oleamide synthesizing activity from rat kidney: identification as cytochrome c.
Driscoll WJ, Chaturvedi S, Mueller GP
J Biol Chem 2007 Aug 3 282(31):22353-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S Licht
Evaluated 3 Aug 2007

A subtype-selective, use-dependent inhibitor of native AMPA receptors.
Nilsen A, England PM
J Am Chem Soc 2007 Apr 25 129(16):4902-3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht
Evaluated 22 May 2007

K+ channel selectivity depends on kinetic as well as thermodynamic factors.
Grabe M, Bichet D, …, Jan YN, Jan LY
Proc Natl Acad Sci U S A 2006 Sep 26 103(39):14361-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht
Evaluated 29 Mar 2007

Cooperative gating between single HCN pacemaker channels.
Dekker JP, Yellen G
J Gen Physiol 2006 Nov 128(5):561-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht
Evaluated 9 Jan 2007

In vivo incorporation of multiple unnatural amino acids through nonsense and frameshift suppression.
Rodriguez EA, Lester HA, Dougherty DA
Proc Natl Acad Sci U S A 2006 Jun 6 103(23):8650-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht
Evaluated 23 Oct 2006

Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase.
Weng J, Cao Y, Moss N, Zhou M
J Biol Chem 2006 Jun 2 281(22):15194-200 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht
Evaluated 31 Jul 2006

Library versus library recognition and inhibition of the HIV-1 Nef allelome.
Olszewski A, Weiss GA
J Am Chem Soc 2005 Sep 7 127(35):12178-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Benjamin Cravatt / Stuart S Licht
Evaluated 15 May 2006

Photoinactivation of native AMPA receptors reveals their real-time trafficking.
Adesnik H, Nicoll RA, England PM
Neuron 2005 Dec 22 48(6):977-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Noam Ziv / Jan-Marino Ramirez / Michael Ehlers / Stuart S Licht
Evaluated 7 Apr 2006

Imaging membrane potential in dendritic spines.
Nuriya M, Jiang J, …, Eisenthal KB, Yuste R
Proc Natl Acad Sci U S A 2006 Jan 17 103(3):786-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht
Evaluated 9 Feb 2006

Passive all-optical force clamp for high-resolution laser trapping.
Greenleaf WJ, Woodside MT, Abbondanzieri EA, Block SM
Phys Rev Lett 2005 Nov 11 95(20):208102 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht
Evaluated 8 Dec 2005

Light activated recombination.
Link KH, Shi Y, Koh JT
J Am Chem Soc 2005 Sep 28 127(38):13088-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S Licht
Evaluated 19 Oct 2005

Heterogeneity in synaptic transmission along a Drosophila larval motor axon.
Guerrero G, Reiff DF, …, Goodman CS, Isacoff EY
Nat Neurosci 2005 Sep 8(9):1188-96 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht / Michael Ehlers
Evaluated 2 Sep 2005

A chemical-genetic approach to studying neurotrophin signaling.
Chen X, Ye H, …, Shokat KM, Ginty DD
Neuron 2005 Apr 7 46(1):13-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Silvia Arber / Jeffrey Macklis / Stuart S Licht
Evaluated 25 Jul 2005

Observation of a power-law memory kernel for fluctuations within a single protein molecule.
Min W, Luo G, …, Kou SC, Xie XS
Phys Rev Lett 2005 May 20 94(19):198302 [abstract on PubMed] [related articles] [order article]
Selected by | Stuart S Licht
Evaluated 2 Jun 2005

The stability of a stochastic CaMKII switch: dependence on the number of enzyme molecules and protein turnover.
Miller P, Zhabotinsky AM, Lisman JE, Wang XJ
PLoS Biol 2005 Apr 3(4):e107 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht
Evaluated 22 Apr 2005

Single-molecule observation of the catalytic subunit of cAMP-dependent protein kinase binding to an inhibitor peptide.
Xie H, Braha O, …, Cheley S, Bayley H
Chem Biol 2005 Jan 12(1):109-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S Licht
Evaluated 14 Feb 2005

High-fidelity DNA sensing by protein binding fluctuations.
Tlusty T, Bar-Ziv R, Libchaber A
Phys Rev Lett 2004 Dec 17 93(25):258103 [abstract on PubMed] [related articles] [order article]
Selected by | Stuart S Licht
Evaluated 10 Jan 2005

Photochemically knocking out glutamate receptors in vivo.
Chambers JJ, Gouda H, …, Kuntz ID, England PM
J Am Chem Soc 2004 Nov 3 126(43):13886-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S Licht
Evaluated 5 Nov 2004

Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers.
Suchyna TM, Tape SE, …, Sachs F, Gottlieb PA
Nature 2004 Jul 8 430(6996):235-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S Licht
Evaluated 16 Aug 2004

A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom.
Lee SY, MacKinnon R
Nature 2004 Jul 8 430(6996):232-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S Licht
Evaluated 16 Aug 2004

DNA display III. Solid-phase organic synthesis on unprotected DNA.
Halpin DR, Lee JA, Wrenn SJ, Harbury PB
PLoS Biol 2004 Jul 2(7):E175 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht
Evaluated 6 Jul 2004

DNA display II. Genetic manipulation of combinatorial chemistry libraries for small-molecule evolution.
Halpin DR, Harbury PB
PLoS Biol 2004 Jul 2(7):E174 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht / Burckhard Seelig
Evaluated 6 Jul 2004

DNA display I. Sequence-encoded routing of DNA populations.
Halpin DR, Harbury PB
PLoS Biol 2004 Jul 2(7):E173 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht
Evaluated 6 Jul 2004

ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating.
Bienengraeber M, Olson TM, …, Alekseev AE, Terzic A
Nat Genet 2004 Apr 36(4):382-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht
Evaluated 29 Apr 2004

Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors.
Ju W, Morishita W, …, Ellisman MH, Malenka RC
Nat Neurosci 2004 Mar 7(3):244-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Mayford / Stuart S Licht
Evaluated 30 Mar 2004

A limiting speed for protein folding at low solvent viscosity.
Qiu L, Hagen SJ
J Am Chem Soc 2004 Mar 24 126(11):3398-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S Licht
Evaluated 23 Mar 2004

Millisecond kinetics on a microfluidic chip using nanoliters of reagents.
Song H, Ismagilov RF
J Am Chem Soc 2003 Nov 26 125(47):14613-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht
Evaluated 23 Jan 2004

Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins.
Miyashita O, Onuchic JN, Wolynes PG
Proc Natl Acad Sci U S A 2003 Oct 28 100(22):12570-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart S Licht
Evaluated 17 Nov 2003

Tuning the heterogeneous early folding dynamics of phosphoglycerate kinase.
Osváth S, Sabelko JJ, Gruebele M
J Mol Biol 2003 Oct 10 333(1):187-99 [abstract on PubMed] [related articles] [order article]
Selected by | Stuart S Licht
Evaluated 26 Sep 2003

^Top  Back to Faculty Members


© 1999-2010 Faculty of 1000 Ltd unless otherwise stated. < info@f1000.com >   Terms and conditions   Legal info