Isaac Kohane sponsors free access to F1000 for KEMRI -Wellcome Trust Research Programme, Kenya. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

http://www.chip.org/people/isaackohane.html

Rare variants create synthetic genome-wide associations. Dickson SP, Wang K, …, Hakonarson H, Goldstein DB PLoS Biol 2010 8(1):e1000294 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane / Thomas Hund Evaluated 2 Feb 2010 Plasma cytokine profiles in Fragile X subjects: Is there a role for cytokines in the pathogenesis? Ashwood P, Nguyen DV, …, Hagerman RJ, Tassone F Brain Behav Immun 2010 Jan 23 [abstract on PubMed] [related articles] [full text] Selected by | Isaac Kohane Evaluated 2 Feb 2010 Aging mice show a decreasing correlation of gene expression within genetic modules. Southworth LK, Owen AB, Kim SK PLoS Genet 2009 Dec 5(12):e1000776 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane Evaluated 27 Jan 2010 Disease signatures are robust across tissues and experiments. Dudley JT, Tibshirani R, Deshpande T, Butte AJ Mol Syst Biol 2009 5:307 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane / Nicola Mulder Evaluated 7 Oct 2009 Perioperative activation of disseminated tumor cells in bone marrow of patients with prostate cancer. Weckermann D, Polzer B, …, Harzmann R, Klein CA J Clin Oncol 2009 Apr 1 27(10):1549-56 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Kamila Naxerova and Isaac Kohane Evaluated 12 Jun 2009 A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Tarpey PS, Smith R, …, Futreal PA, Stratton MR Nat Genet 2009 May 41(5):535-43 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Monica Justice / R Frank Kooy / Isaac Kohane / Sue Malcolm Evaluated 14 May 2009 Systemic endocrine instigation of indolent tumor growth requires osteopontin. McAllister SS, Gifford AM, …, Repasky EA, Weinberg RA Cell 2008 Jun 13 133(6):994-1005 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Doug Strand and Simon Hayward / Kamila Naxerova and Isaac Kohane Evaluated 9 Dec 2008 A functional genetic link between distinct developmental language disorders. Vernes SC, Newbury DF, …, Monaco AP, Fisher SE N Engl J Med 2008 Nov 27 359(22):2337-45 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane / Sayeda Abu-Amero and Sue Malcolm Evaluated 21 Nov 2008 Altered gene expression and function of peripheral blood natural killer cells in children with autism. Enstrom AM, Lit L, …, Sharp FR, Ashwood P Brain Behav Immun 2008 Aug 14 [abstract on PubMed] [related articles] [full text] Selected by | Isaac Kohane Evaluated 15 Sep 2008 Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. Li XY, MacArthur S, …, Eisen MB, Biggin MD PLoS Biol 2008 Feb 6(2):e27 [abstract on PubMed] [related articles] [FREE full text] Selected by | Manfred Frasch / Isaac Kohane Evaluated 30 Jul 2008 Combinatorial patterns of histone acetylations and methylations in the human genome. Wang Z, Zang C, …, Zhang MQ, Zhao K Nat Genet 2008 Jul 40(7):897-903 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Isaac Kohane / Ian Dunham Evaluated 23 Jun 2008 Genome-wide analysis reveals a complex pattern of genomic imprinting in mice. Wolf JB, Cheverud JM, Roseman C, Hager R PLoS Genet 2008 Jun 4(6):e1000091 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane Evaluated 19 Jun 2008 Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion. Quinlan MP, Quatela SE, Philips MR, Settleman J Mol Cell Biol 2008 Apr 28(8):2659-74 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Isaac Kohane Evaluated 19 Jun 2008 Survival of cancer cells is maintained by EGFR independent of its kinase activity. Weihua Z, Tsan R, …, Fidler IJ, Hung MC Cancer Cell 2008 May 13(5):385-93 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Isaac Kohane / Sjur Olsnes / Len Neckers Evaluated 12 May 2008 Unintentional miRNA Ablation is a Risk Factor in Gene Knockout Studies: A Short Report. Osokine I, Hsu R, Loeb GB, McManus MT PLoS Genet 2008 Feb 15 4:e34 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane / Marjori Matzke Evaluated 25 Feb 2008 A macrophage gene expression signature defines a field effect in the lung tumor microenvironment. Stearman RS, Dwyer-Nield L, …, Malkinson AM, Geraci MW Cancer Res 2008 Jan 1 68(1):34-43 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Isaac Kohane Evaluated 9 Jan 2008 Blood levels of mercury are related to diagnosis of autism: a reanalysis of an important data set. Desoto MC, Hitlan RT J Child Neurol 2007 Nov 22(11):1308-11 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Isaac Kohane Evaluated 27 Nov 2007 Gene expression changes in children with autism. Gregg JP, Lit L, …, Pessah IN, Sharp FR Genomics 2008 Jan 91(1):22-29 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Isaac Kohane Evaluated 27 Nov 2007 A unified genetic theory for sporadic and inherited autism. Zhao X, Leotta A, …, Ye K, Wigler M Proc Natl Acad Sci U S A 2007 Jul 31 104(31):12831-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane Evaluated 1 Aug 2007 The active FMR1 promoter is associated with a large domain of altered chromatin conformation with embedded local histone modifications. Gheldof N, Tabuchi TM, Dekker J Proc Natl Acad Sci U S A 2006 Aug 15 103(33):12463-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane Evaluated 23 Apr 2007 Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos. Yu Z, Jian Z, …, Purisima E, Wang E Nucleic Acids Res 2007 35(1):152-64 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane Evaluated 10 Jan 2007 An E2F/miR-20a autoregulatory feedback loop. Sylvestre Y, De Guire V, …, Ferbeyre G, Chartrand P J Biol Chem 2007 Jan 26 282(4):2135-43 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Isaac Kohane Evaluated 9 Jan 2007 miR-7b, a microRNA up-regulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation. Lee HJ, Palkovits M, Young WS Proc Natl Acad Sci U S A 2006 Oct 17 103(42):15669-74 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane Evaluated 26 Oct 2006 A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, Sachidanandam R, Hannon GJ, Carmell MA Nature 2006 Jul 13 442(7099):199-202 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Isaac Kohane Evaluated 3 Jul 2006 The contributions of normal variation and genetic background to mammalian gene expression. Pritchard C, Coil D, …, Hsu L, Nelson PS Genome Biol 2006 7(3):R26 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane / Carmen Sapienza Evaluated 16 May 2006 Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Grant SF, Thorleifsson G, …, Kong A, Stefansson K Nat Genet 2006 Mar 38(3):320-3 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Isaac Kohane Evaluated 26 Jan 2006 Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R Cell 2005 Nov 18 123(4):631-40 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Isaac Kohane / Bino John Evaluated 14 Nov 2005 Aging and gene expression in the primate brain. Fraser HB, Khaitovich P, …, Pääbo S, Eisen MB PLoS Biol 2005 Sep 3(9):e274 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane Evaluated 17 Aug 2005 On the probability that a novel variant is a disease-causing mutation. Mitchell AA, Chakravarti A, Cutler DJ Genome Res 2005 Jul 15(7):960-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane / Darryl Nishimura Evaluated 29 Jul 2005 A high frequency of overlapping gene expression in compacted eukaryotic genomes. Williams BA, Slamovits CH, …, Fast NM, Keeling PJ Proc Natl Acad Sci U S A 2005 Aug 2 102(31):10936-41 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane Evaluated 28 Jul 2005 Identification of hundreds of conserved and nonconserved human microRNAs. Bentwich I, Avniel A, …, Spector Y, Bentwich Z Nat Genet 2005 Jul 37(7):766-70 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Richard L Stevens / Oliver Hobert / Isaac Kohane / Ulf Pettersson / Claudia Bagni Evaluated 28 Jun 2005 Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Impey S, McCorkle SR, …, Mandel G, Goodman RH Cell 2004 Dec 29 119(7):1041-54 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Mark Fortini / Andrew D Sharrocks / Albert La Spada / Isaac Kohane Evaluated 16 May 2005 Trial and error: prognostic gene signature study design altered. Tuma RS J Natl Cancer Inst 2005 Mar 2 97(5):331-3 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane Evaluated 15 Mar 2005 Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Scaffidi P, Misteli T Nat Med 2005 Apr 11(4):440-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane / Peter Scambler Evaluated 14 Mar 2005 Evolution of transcription factor DNA binding sites. Kotelnikova EA, Makeev VJ, Gelfand MS Gene 2005 Mar 14 347(2):255-63 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Isaac Kohane Evaluated 2 Mar 2005 Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Lim LP, Lau NC, …, Linsley PS, Johnson JM Nature 2005 Feb 17 433(7027):769-73 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Isaac Kohane / Harukazu Nakamura / Fritz Eckstein / Ulf Pettersson / Andrew D Sharrocks / Detlef Weigel / Richard Carthew / Alejandro Sanchez-Alvarado / Vishvanath Nene / Miles Wilkinson Evaluated 23 Feb 2005 Mutations in a novel gene, encoding a single transmembrane domain protein are associated with familial glucocorticoid deficiency type 2. Metherell LA, Cooray S, …, Begeot M, Clark AJ Endocr Res 2004 Nov 30(4):889-90 [abstract on PubMed] [related articles] [order article] Selected by | Isaac Kohane Evaluated 22 Feb 2005 Architecture of a validated microRNA::target interaction. Vella MC, Reinert K, Slack FJ Chem Biol 2004 Dec 11(12):1619-23 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Isaac Kohane Evaluated 15 Feb 2005 Modelling the correlation between the activities of adjacent genes in Drosophila. Thygesen HH, Zwinderman AH BMC Bioinformatics 2005 6:10 [abstract on PubMed] [related articles] [FREE full text] Selected by | Isaac Kohane Evaluated 9 Feb 2005

^Top  Back to Faculty Members