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Raphael Kopan
Washington University, United States of America
Faculty Member: Developmental Biology > Developmental Molecular Mechanisms [ since 3 October 2003 ]
[
Evaluations
]
selected articles
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Evaluations
The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition.
Han J, Ma I, Hendzel MJ, Allalunis-Turner J
Breast Cancer Res
2009 Aug 6
11
(4):R57 [
abstract on PubMed
] [
related articles
] [
FREE full text
]
Selected by
| Raphael Kopan
Evaluated 20 Aug 2009
Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.
Real PJ, Tosello V, …, Ai W, Ferrando A
Nat Med
2009 Jan
15
(1):50-8 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Raphael Kopan
Evaluated 3 Feb 2009
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition.
Cordle J, Johnson S, …, Lea SM, Handford PA
Nat Struct Mol Biol
2008 Aug
15
(8):849-57 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Raphael Kopan
Evaluated 10 Sep 2008
OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development.
Komatsu H, Chao MY, …, Boxem M, Hart AC
PLoS Biol
2008 Aug 12
6
(8):e196 [
abstract on PubMed
] [
related articles
] [
FREE full text
]
Selected by
| Helen Chamberlin / Raphael Kopan
Evaluated 10 Sep 2008
Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1.
Tagami S, Okochi M, …, Chiba S, Takeda M
Mol Cell Biol
2008 Jan
28
(1):165-76 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Raphael Kopan / David Bilder
Evaluated 26 Nov 2007
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.
Nam Y, Sliz P, …, Aster JC, Blacklow SC
Proc Natl Acad Sci U S A
2007 Feb 13
104
(7):2103-8 [
abstract on PubMed
] [
related articles
] [
FREE full text
]
Selected by
| Raphael Kopan / Patricia Simpson
Evaluated 26 Feb 2007
DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur.
Nichols JT, Miyamoto A, …, Yao C, Weinmaster G
J Cell Biol
2007 Feb 12
176
(4):445-58 [
abstract on PubMed
] [
related articles
] [
FREE full text
]
Selected by
| Raphael Kopan
Evaluated 26 Feb 2007
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
Takahashi K, Yamanaka S
Cell
2006 Aug 25
126
(4):663-76 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Thomas Graf / Wolf Reik / Raphael Kopan / Charles Coutelle / Charles Brenner
Evaluated 12 Sep 2006
Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.
Wilson JJ, Kovall RA
Cell
2006 Mar 10
124
(5):985-96 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Raphael Kopan / Zippora Shakked
Evaluated 15 Mar 2006
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Nam Y, Sliz P, …, Aster JC, Blacklow SC
Cell
2006 Mar 10
124
(5):973-83 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Raphael Kopan / Zippora Shakked
Evaluated 15 Mar 2006
Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless.
Koelzer S, Klein T
Dev Biol
2006 Jan 1
289
(1):77-90 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Raphael Kopan / Alfonso Martinez Arias
Evaluated 10 Feb 2006
A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.
Hass MR, Yankner BA
J Biol Chem
2005 Nov 4
280
(44):36895-904 [
abstract on PubMed
] [
related articles
] [
FREE full text
]
Selected by
| Raphael Kopan
Evaluated 1 Sep 2005
Mutations in NOTCH1 cause aortic valve disease.
Garg V, Muth AN, …, Grossfeld PD, Srivastava D
Nature
2005 Sep 8
437
(7056):270-4 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Raphael Kopan
Evaluated 26 Jul 2005
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells.
Domenga V, Fardoux P, …, Gridley T, Joutel A
Genes Dev
2004 Nov 15
18
(22):2730-5 [
abstract on PubMed
] [
related articles
] [
FREE full text
]
Selected by
| Raphael Kopan
Evaluated 23 Feb 2005
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
Fryer CJ, White JB, Jones KA
Mol Cell
2004 Nov 19
16
(4):509-20 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Ronald Conaway / Raphael Kopan
Evaluated 17 Dec 2004
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche.
Blanpain C, Lowry WE, …, Polak L, Fuchs E
Cell
2004 Sep 3
118
(5):635-48 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Colin Stewart / Raphael Kopan
Evaluated 16 Nov 2004
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.
Amsen D, Blander JM, …, Honjo T, Flavell RA
Cell
2004 May 14
117
(4):515-26 [
abstract on PubMed
] [
related articles
] [
order article
]
Selected by
| David Chaplin / Chen Dong / Warren Pear / Raphael Kopan / Alan Houghton
Evaluated 23 Jul 2004
Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor.
Gupta-Rossi N, Six E, …, Israël A, Brou C
J Cell Biol
2004 Jul 5
166
(1):73-83 [
abstract on PubMed
] [
related articles
] [
FREE full text
]
Selected by
| Mark von Zastrow / Raphael Kopan / Valera Vasioukhin / Mark Fortini / Carlos Ibanez
Evaluated 14 Jul 2004
Identification of p53 regulators by genome-wide functional analysis.
Huang Q, Raya A, …, Izpisua-Belmonte JC, Schultz PG
Proc Natl Acad Sci U S A
2004 Mar 9
101
(10):3456-61 [
abstract on PubMed
] [
related articles
] [
FREE full text
]
Selected by
| Raphael Kopan
Evaluated 28 Jun 2004
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.
Cao X, Südhof TC
J Biol Chem
2004 Jun 4
279
(23):24601-11 [
abstract on PubMed
] [
related articles
] [
FREE full text
]
Selected by
| Raphael Kopan
Evaluated 28 Jun 2004
Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination.
Raya A, Kawakami Y, …, Feijó JA, Izpisúa Belmonte JC
Nature
2004 Jan 8
427
(6970):121-8 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Raphael Kopan / Ken Irvine / David Ish-Horowicz / Alfonso Martinez Arias
Evaluated 16 Jan 2004
An O-fucose site in the ligand binding domain inhibits Notch activation.
Lei L, Xu A, Panin VM, Irvine KD
Development
2003 Dec
130
(26):6411-21 [
abstract on PubMed
] [
related articles
] [
FREE full text
]
Selected by
| Raphael Kopan
Evaluated 5 Dec 2003
Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate.
Ramain P, Khechumian K, …, Ackermann C, Heitzler P
Curr Biol
2001 Nov 13
11
(22):1729-38 [
abstract on PubMed
] [
related articles
] [
order article
]
Selected by
| Raphael Kopan
Evaluated 7 Nov 2003
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Li YM, Xu M, …, Shafer JA, Gardell SJ
Nature
2000 Jun 8
405
(6787):689-94 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Raphael Kopan
Evaluated 7 Nov 2003
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Wolfe MS, Xia W, …, Kimberly WT, Selkoe DJ
Nature
1999 Apr 8
398
(6727):513-7 [
abstract on PubMed
] [
related articles
] [
full text
] [
order article
]
Selected by
| Raphael Kopan
Evaluated 7 Nov 2003
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