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Arthur Christopoulos
Department of Pharmacology, Monash University, Clayton, Australia

Faculty Member: Pharmacology & Drug Discovery > Molecular Pharmacology [ since 9 October 2009 ]
[ Evaluations ]
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Evaluations

Predicting new molecular targets for known drugs.
Keiser MJ, Setola V, …, Shoichet BK, Roth BL
Nature 2009 Nov 12 462(7270):175-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joel Bockaert / Arthur Christopoulos
Evaluated 18 Dec 2009

Crystal structure of opsin in its G-protein-interacting conformation.
Scheerer P, Park JH, …, Hofmann KP, Ernst OP
Nature 2008 Sep 25 455(7212):497-502 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Christopoulos / Alexey Amunts and Nathan Nelson / Thomas Baranski / Gordon Fain
Evaluated 29 Sep 2008

Crystal structure of squid rhodopsin.
Murakami M, Kouyama T
Nature 2008 May 15 453(7193):363-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Leonardo Pardo / Arthur Christopoulos
Evaluated 4 Jun 2008

Identification of a serotonin/glutamate receptor complex implicated in psychosis.
González-Maeso J, Ang RL, …, Meana JJ, Sealfon SC
Nature 2008 Mar 6 452(7183):93-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Christopoulos / Soeren Sheikh
Evaluated 14 Mar 2008


Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Rasmussen SG, Choi HJ, …, Weis WI, Kobilka BK
Nature 2007 Nov 15 450(7168):383-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Leonardo Pardo / Fred Dyda / Carmen Dessauer / Arthur Christopoulos / Patricia C. Weber / Ian Hall / Marc Caron / Stephan Nussberger
Evaluated 23 Nov 2007

Drug-target network.
Yildirim MA, Goh KI, …, Barabási AL, Vidal M
Nat Biotechnol 2007 Oct 25(10):1119-26 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Christopoulos
Evaluated 16 Oct 2007

Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation.
Jäger D, Schmalenbach C, …, Höltje HD, Mohr K
J Biol Chem 2007 Nov 30 282(48):34968-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Christopoulos
Evaluated 9 Oct 2007

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein.
Whorton MR, Bokoch MP, …, Kobilka B, Sunahara RK
Proc Natl Acad Sci U S A 2007 May 1 104(18):7682-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew Tobin / Carmen Dessauer / Arthur Christopoulos
Evaluated 25 Jul 2007

Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity.
Chanrion B, Mannoury la Cour C, …, Bockaert J, Marin P
Proc Natl Acad Sci U S A 2007 May 8 104(19):8119-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Christopoulos
Evaluated 25 Jul 2007

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.
Armbruster BN, Li X, …, Herlitze S, Roth BL
Proc Natl Acad Sci U S A 2007 Mar 20 104(12):5163-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Christopoulos / Robert Malenka / Guoping Feng / Marie-Francoise Chesselet
Evaluated 22 Mar 2007

Small-molecule agonists for the glucagon-like peptide 1 receptor.
Knudsen LB, Kiel D, …, May J, Lau J
Proc Natl Acad Sci U S A 2007 Jan 16 104(3):937-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Subhash Sinha / Arthur Christopoulos
Evaluated 6 Mar 2007

Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors.
Rondard P, Liu J, …, Labesse G, Pin JP
J Biol Chem 2006 Aug 25 281(34):24653-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ralf Jockers / Arthur Christopoulos
Evaluated 14 Nov 2006

Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor 1alpha.
Tateyama M, Kubo Y
Proc Natl Acad Sci U S A 2006 Jan 24 103(4):1124-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Christopoulos
Evaluated 10 Nov 2006

Determining the potency and molecular mechanism of action of insurmountable antagonists.
Kenakin T, Jenkinson S, Watson C
J Pharmacol Exp Ther 2006 Nov 319(2):710-23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Christopoulos
Evaluated 10 Nov 2006

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.
Inglese J, Auld DS, …, Zheng W, Austin CP
Proc Natl Acad Sci U S A 2006 Aug 1 103(31):11473-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Lazo / Arthur Christopoulos
Evaluated 18 Aug 2006

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor.
Yao X, Parnot C, …, Farrens D, Kobilka B
Nat Chem Biol 2006 Aug 2(8):417-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Leonardo Pardo / Arthur Christopoulos
Evaluated 27 Jul 2006

Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome.
Slessareva JE, Routt SM, …, Bankaitis VA, Dohlman HG
Cell 2006 Jul 14 126(1):191-203 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arthur Christopoulos / Harald Stenmark / Thomas Baranski / Miguel Penalva
Evaluated 27 Jul 2006

Agonist-induced cell surface trafficking of an intracellularly sequestered D1 dopamine receptor homo-oligomer.
Kong MM, Fan T, …, O'dowd BF, George SR
Mol Pharmacol 2006 Jul 70(1):78-89 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Christopoulos
Evaluated 27 Jul 2006

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