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 | Andrew S McCallion
McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins Medical Institute, Baltimore, United States of America | | | Faculty Member: Genomics & Genetics > Genomics [ since 11 August 2004 ] |
| | [ Biography ] [ Homepage ] [ Evaluations ] | Biography
Dr Andrew McCallion is a native of Northern Ireland and grew up in Belfast. His undergraduate and graduate training was completed at the Queen's University of Belfast and the University of Glasgow (Scotland). He spent a brief period as a Staff Scientist for Neuropa Ltd (UK) a biotech startup with a focus on drug target development for neurodegenerative disorders. His work with Dr Aravinda Chakravarti at Johns Hopkins uncovered genetic interaction between the RET receptor tyrosine kinase and the endothelin type B receptor in the genesis of Hirschsprung disease (HSCR) and subsequently recapitulated the clinical phenotype in mice. Dr McCallion was appointed as Assistant Professor of Comparative Medicine and in the McKusick-Nathans Institute of Genetic Medicine (IGM) in mid 2003. His present work focuses on the determination of biological and disease relevance of functional noncoding DNA, using functional genomic approaches in model organisms. Recent work in his lab has contributed to the identification of a novel and relatively common noncoding HSCR-susceptibility mutation at RET - a collaborative effort with the group of Dr Chakravarti (IGM, Institute of Genetic Medicine). More recently Dr McCallion and his colleague Dr Shannon Fisher in the IGM have developed transgenic screening techniques in Zebrafish that facilitate the rapid examination of putatively regulatory noncoding DNA. His work aims to integrate molecular, cellular and in vivo strategies to establish paradigms for comprehensive functional analysis of non-coding, putatively regulatory sequences that may be applied to virtually any locus. | Home page
http://www.hopkinsmedicine.org/geneticmedicine/ |
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