 | Andrew D Sharrocks
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom | | | Faculty Member: Cell Biology > Control of Gene Expression [ since 3 September 2001 ] |
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Andrew D Sharrocks sponsors free access to F1000 for The International Livestock Research Institute, Addis Ababa, Ethiopia. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details). | Biography
My research group is part of a larger group of researchers who focus on understanding the basic molecular processes that underly tumourigenesis. Chiefly these areas cover cell signalling, gene expression and cell cycle control.
My own research focuses on understanding how cellular signalling pathways impact on transcriptional regulation. We focus on several pathways; MAP kinases, cell cycle-dependent kinases (CDKs and polo kinases), and DNA damage pathways. At the nuclear level, we focus on ETS-domain and forkhead transcription factors. Major projects in the lab involve investigating global responses to signalling through particular transcriptional regulators using postgenomic technologies, and more mechanistic studies aimed at understanding how signalling changes the activities of transcriptional regulators. Another area of interest is protein sumoylation and how this impacts on transcription factor activity and cross-talks with signalling pathways. In terms of biological context, we are most interested in investigating generic processes such as cell cycle control, cellular proliferation and stress responses. While focusing on basic mechanisms we also are translating some of our findings into a cancer context.
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http://www.ls.manchester.ac.uk/people/profile/?id=889 |
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