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Filippo Giancotti
Memorial Sloan-Kettering Cancer Center, United States of America

Faculty Member: Cell Biology > Cell Adhesion [ since 16 September 2002 ]
[ Evaluations ]
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Evaluations

New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering.
Saltel F, Mortier E, …, Liu W, Wehrle-Haller B
J Cell Biol 2009 Nov 30 187(5):715-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ilaria Esposito and Filippo Giancotti / Feng Ye and Mark Ginsberg
Evaluated 4 Dec 2009

Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion.
Maher MT, Flozak AS, …, Chenn A, Gottardi CJ
J Cell Biol 2009 Jul 27 186(2):219-28 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Filippo Giancotti / Chaya Kalcheim / Feng Ye and Mark Ginsberg
Evaluated 30 Jul 2009

A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes.
Zoncu R, Perera RM, …, Toomre D, De Camilli P
Cell 2009 Mar 20 136(6):1110-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Lowe / Ilaria Esposito and Filippo Giancotti
Evaluated 12 May 2009

A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis.
Philippar U, Roussos ET, …, Condeelis JS, Gertler FB
Dev Cell 2008 Dec 15(6):813-28 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hervé Acloque and M. Angela Nieto / Filippo Giancotti / Cory Simpson and Kathleen J. Green
Evaluated 14 Jan 2009

Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains.
Ishikawa HO, Takeuchi H, Haltiwanger RS, Irvine KD
Science 2008 Jul 18 321(5887):401-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Filippo Giancotti / Norbert Perrimon / Valeri Vasioukhin / David Strutt / Hee Sool Rho and Heng Zhu
Evaluated 22 Jul 2008

A central function for perlecan in skeletal muscle and cardiovascular development.
Zoeller JJ, McQuillan A, …, Ho SY, Iozzo RV
J Cell Biol 2008 Apr 21 181(2):381-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Filippo Giancotti / Richard L. Stevens
Evaluated 30 Apr 2008

Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.
Wu X, Tu X, …, Williams DA, Long F
Cell 2008 Apr 18 133(2):340-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Filippo Giancotti / Gregory Dressler / John Wallingford / Cory L. Simpson and Kathleen J. Green
Evaluated 29 Apr 2008


Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1.
Goetz JG, Joshi B, …, Kojic LD, Nabi IR
J Cell Biol 2008 Mar 17 [abstract on PubMed] [related articles] [full text]
Selected by | Filippo Giancotti
Evaluated 19 Mar 2008

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells.
Gaggioli C, Hooper S, …, Harrington K, Sahai E
Nat Cell Biol 2007 Dec 9(12):1392-400 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz / Filippo Giancotti / Carol Otey / Frank de Gruijl / C. Michael DiPersio / Anna Huttenlocher / Kathleen J. Green
Evaluated 18 Dec 2007

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer.
Hermann PC, Huber SL, …, Bruns CJ, Heeschen C
Cell Stem Cell 2007 Sep 13 1(3):313-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christopher Marshall / Filippo Giancotti
Evaluated 23 Nov 2007

Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3.
Nishimura T, Kaibuchi K
Dev Cell 2007 Jul 13(1):15-28 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alan Rick Horwitz / James Casanova / Michel Labouesse / Filippo Giancotti
Evaluated 20 Sep 2007

Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer.
Ceteci F, Ceteci S, …, Götz R, Rapp UR
Cancer Cell 2007 Aug 12(2):145-59 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Avri Ben-Ze'ev / Filippo Giancotti
Evaluated 20 Sep 2007

Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.
Serrels B, Serrels A, …, Jones GE, Frame MC
Nat Cell Biol 2007 Sep 9(9):1046-56 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Filippo Giancotti
Evaluated 18 Sep 2007

GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland.
Kouros-Mehr H, Slorach EM, Sternlicht MD, Werb Z
Cell 2006 Dec 1 127(5):1041-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Filippo Giancotti
Evaluated 2 Apr 2007

P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin.
Yang L, Lin C, Liu ZR
Cell 2006 Oct 6 127(1):139-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Filippo Giancotti
Evaluated 11 Jan 2007

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells.
Yook JI, Li XY, …, Fearon ER, Weiss SJ
Nat Cell Biol 2006 Dec 8(12):1398-406 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Avri Ben-Ze'ev / Filippo Giancotti / Herbert Steinbeisser
Evaluated 9 Jan 2007

JNK2 is a positive regulator of the cJun transcription factor.
Jaeschke A, Karasarides M, …, Shokat KM, Davis RJ
Mol Cell 2006 Sep 15 23(6):899-911 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Abraham / Filippo Giancotti / Simon Cook
Evaluated 26 Sep 2006

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling.
Massoumi R, Chmielarska K, …, Pfeifer A, Fässler R
Cell 2006 May 19 125(4):665-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Filippo Giancotti
Evaluated 13 Jul 2006

Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene.
Kim M, Gans JD, …, Granter SR, Chin L
Cell 2006 Jun 30 125(7):1269-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Filippo Giancotti
Evaluated 13 Jul 2006

A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
Rodriguez-Viciana P, Oses-Prieto J, …, Fried M, McCormick F
Mol Cell 2006 Apr 21 22(2):217-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Filippo Giancotti / Zhong-Yin Zhang
Evaluated 3 May 2006

RNA-binding IMPs promote cell adhesion and invadopodia formation.
Vikesaa J, Hansen TV, …, Christiansen J, Nielsen FC
EMBO J 2006 Apr 5 25(7):1456-68 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Filippo Giancotti / Arthur Mercurio
Evaluated 2 May 2006

Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth.
Moberg KH, Schelble S, Burdick SK, Hariharan IK
Dev Cell 2005 Nov 9(5):699-710 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Valera Vasioukhin / Filippo Giancotti / Alfonso Martinez Arias
Evaluated 6 Dec 2005

The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking.
Vaccari T, Bilder D
Dev Cell 2005 Nov 9(5):687-98 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Valera Vasioukhin / Filippo Giancotti / Alfonso Martinez Arias / Harald Stenmark / Marcos Gonzalez-Gaitan
Evaluated 6 Dec 2005

FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation.
Wu X, Gan B, Yoo Y, Guan JL
Dev Cell 2005 Aug 9(2):185-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Filippo Giancotti
Evaluated 13 Sep 2005

The kinase domain of titin controls muscle gene expression and protein turnover.
Lange S, Xiang F, …, Udd B, Gautel M
Science 2005 Jun 10 308(5728):1599-603 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lars-Eric Thornell / Anthony Means / Filippo Giancotti
Evaluated 24 Jun 2005

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity.
Ozdamar B, Bose R, …, Zhang Y, Wrana JL
Science 2005 Mar 11 307(5715):1603-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Victor Thannickal / Keith Mostov / David Wotton / David Bilder / Valera Vasioukhin / Filippo Giancotti / Alfonso Martinez Arias / Andreas Wodarz / Francisco Sanchez-Madrid
Evaluated 8 Apr 2005

Activation of FAK and Src are receptor-proximal events required for netrin signaling.
Li W, Lee J, …, Hong K, Guan KL
Nat Neurosci 2004 Nov 7(11):1213-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Filippo Giancotti / Yoshimi Takai / Michael Schaller
Evaluated 16 Nov 2004

Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction.
Liu G, Beggs H, …, Wu J, Rao Y
Nat Neurosci 2004 Nov 7(11):1222-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Filippo Giancotti / Michael Schaller
Evaluated 16 Nov 2004

Focal adhesion kinase in netrin-1 signaling.
Ren XR, Ming GL, …, Mei L, Xiong WC
Nat Neurosci 2004 Nov 7(11):1204-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Filippo Giancotti / Michael Schaller
Evaluated 16 Nov 2004

Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction.
White DE, Kurpios NA, …, Mueller U, Muller WJ
Cancer Cell 2004 Aug 6(2):159-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Charles Streuli / Filippo Giancotti
Evaluated 15 Sep 2004

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.
Yang J, Mani SA, …, Richardson A, Weinberg RA
Cell 2004 Jun 25 117(7):927-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Filippo Giancotti / Kathleen J Green / Surender Kharbanda / Daniel Flynn
Evaluated 8 Jul 2004

Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch.
Ling K, Doughman RL, …, Schaller MD, Anderson RA
J Cell Biol 2003 Dec 22 163(6):1339-49 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / Filippo Giancotti
Evaluated 13 Jan 2004

The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration.
Santoro MM, Gaudino G, Marchisio PC
Dev Cell 2003 Aug 5(2):257-71 [abstract on PubMed] [related articles] [order article]
Selected by | Filippo Giancotti / Arthur Mercurio
Evaluated 2 Oct 2003

Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression.
Zhao J, Bian ZC, …, Chien S, Guan JL
Mol Cell 2003 Jun 11(6):1503-15 [abstract on PubMed] [related articles] [order article]
Selected by | Filippo Giancotti
Evaluated 28 Jul 2003

Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations.
Li R, Mitra N, …, DeGrado WF, Bennett JS
Science 2003 May 2 300(5620):795-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Filippo Giancotti / Martin Humphries
Evaluated 19 May 2003

Structural determinants of integrin recognition by talin.
García-Alvarez B, de Pereda JM, …, Ginsberg MH, Liddington RC
Mol Cell 2003 Jan 11(1):49-58 [abstract on PubMed] [related articles] [order article]
Selected by | Kristina Downing / Filippo Giancotti / Michael Eck
Evaluated 6 Feb 2003

Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin.
Di Paolo G, Pellegrini L, …, Wenk MR, De Camilli P
Nature 2002 Nov 7 420(6911):85-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jean-Antoine Girault / Kenneth Yamada / Mark Ginsberg / Filippo Giancotti
Evaluated 4 Dec 2002

Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.
Ling K, Doughman RL, …, Bunce MW, Anderson RA
Nature 2002 Nov 7 420(6911):89-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jean-Antoine Girault / Kenneth Yamada / Mark Ginsberg / Filippo Giancotti
Evaluated 4 Dec 2002

DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals.
Wang WJ, Kuo JC, Yao CC, Chen RH
J Cell Biol 2002 Oct 14 159(1):169-79 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Filippo Giancotti / Timothy Springer / Jean Schwarzbauer
Evaluated 15 Oct 2002

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