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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Tech Advance
 Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition.
McCoy EL, Iwanaga R, …, Welm AL, Ford HL
J Clin Invest 2009 Sep 119(9):2663-77 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Avri Ben-Ze'ev
Evaluated 23 Nov 2009

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Early dysregulation of cell adhesion and extracellular matrix pathways in breast cancer progression.
Emery LA, Tripathi A, …, Sebastiani P, Rosenberg CL
Am J Pathol 2009 Sep 175(3):1292-302 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Zongga Shi and M. Sharon Stack
Evaluated 23 Nov 2009

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Controversial
 Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer.
Fung JJ, Deupi X, …, Sunahara RK, Kobilka BK
EMBO J 2009 Nov 4 28(21):3315-28 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kok Choi Kong and Andrew Tobin
Evaluated 23 Nov 2009

Recommended
F1000 Factor 3.0

Tech Advance
 Comparing different ODE modelling approaches for gene regulatory networks.
Polynikis A, Hogan SJ, di Bernardo M
J Theor Biol 2009 Dec 21 261(4):511-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alex Fletcher and Philip Maini
Evaluated 23 Nov 2009

Recommended
F1000 Factor 3.0

New Finding
 Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal.
Abou-Khalil R, Le Grand F, …, Montarras D, Chazaud B
Cell Stem Cell 2009 Sep 4 5(3):298-309 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Keren Bismuth and David Sassoon
Evaluated 23 Nov 2009

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Species-specific heterochromatin prevents mitotic chromosome segregation to cause hybrid lethality in Drosophila.
Ferree PM, Barbash DA
PLoS Biol 2009 Oct 7(10):e1000234 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jennifer G DeLuca and P Shing Ho
Evaluated 23 Nov 2009

Exceptional
F1000 Factor 9.0

New Finding
Novel Drug Target
 CRF system recruitment mediates dark side of compulsive eating.
Cottone P, Sabino V, …, Koob GF, Zorrilla EP
Proc Natl Acad Sci U S A 2009 Nov 9 [abstract on PubMed] [related articles] [full text]
Selected by | Markus Heilig
Evaluated 23 Nov 2009

Recommended
F1000 Factor 3.0

New Finding
Refutation
 Input-specific intrasynaptic arrangements of ionotropic glutamate receptors and their impact on postsynaptic responses.
Tarusawa E, Matsui K, …, Fukazawa Y, Shigemoto R
J Neurosci 2009 Oct 14 29(41):12896-908 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jane Sullivan
Evaluated 23 Nov 2009

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
Controversial
 Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.
Ghosal K, Vogt DL, …, Lamb BT, Pimplikar SW
Proc Natl Acad Sci U S A 2009 Oct 27 106(43):18367-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stuart Feinstein
Evaluated 23 Nov 2009


Recommended
F1000 Factor 3.0

New Finding
 Structural insight into partner specificity and phosphoryl transfer in two-component signal transduction.
Casino P, Rubio V, Marina A
Cell 2009 Oct 16 139(2):325-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ann Stock
Evaluated 23 Nov 2009


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