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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation.
Fu M, Sato Y, …, Napoli JL, Heuckeroth RO
Development 2010 Feb 137(4):631-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S Eisen
Evaluated 9 Feb 2010

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
 Valproic acid reduces spatial working memory and cell proliferation in the hippocampus.
Umka J, Mustafa S, …, Bennett G, Wigmore PM
Neuroscience 2010 Mar 10 166(1):15-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Sendtner
Evaluated 9 Feb 2010

Exceptional
F1000 Factor 9.0

New Finding
 PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice.
Baudat F, Buard J, …, Coop G, de Massy B
Science 2009 Dec 31 [abstract on PubMed] [related articles] [full text]
Selected by | Laurie Stevison and Mohamed Noor
Evaluated 9 Feb 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Vinculin regulates cell-surface E-cadherin expression by binding to {beta}-catenin.
Peng X, Cuff LE, Lawton CD, Demali KA
J Cell Sci 2010 Jan 19 [abstract on PubMed] [related articles] [full text]
Selected by | Ronen Zaidel-Bar
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis.
Wang Q, Uhlirova M, Bohmann D
Dev Cell 2010 18:157-64 [full text]
Selected by | Talila Volk
Evaluated 8 Feb 2010

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 A new view of pectin structure revealed by acid hydrolysis and atomic force microscopy.
Round AN, Rigby NM, Macdougall AJ, Morris VJ
Carbohydr Res 2009 Dec 28 [abstract on PubMed] [related articles] [full text]
Selected by | Jocelyn Rose
Evaluated 8 Feb 2010

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates.
Liu B, Larsson L, …, Grantham J, Nystrom T
Cell 2010 140:257-67 [full text]
Selected by | Andrei Fagarasanu, Fred Mast and Richard Rachubinski
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 Elucidation of the complete ferrichrome A biosynthetic pathway in Ustilago maydis.
Winterberg B, Uhlmann S, …, Kahmann R, Schirawski J
Mol Microbiol 2010 Jan 12 [abstract on PubMed] [related articles] [full text]
Selected by | William Holloman
Evaluated 5 Feb 2010

Exceptional
F1000 Factor 9.0

New Finding
 Epigenetic regulation of the honey bee transcriptome: unravelling the nature of methylated genes.
Foret S, Kucharski R, …, Lockett GA, Maleszka R
BMC Genomics 2009 10:472 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Line Bay and Andrew Baird
Evaluated 5 Feb 2010

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition.
Rasola A, Sciacovelli M, …, Brusilow WS, Bernardi P
Proc Natl Acad Sci U S A 2010 Jan 12 107(2):726-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mar González-Barroso and Eduardo Rial
Evaluated 5 Feb 2010


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