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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella.
Lechtreck KF, Johnson EC, …, Ikebe M, Witman GB
J Cell Biol 2009 Dec 28 187(7):1117-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Maureen Wirschell and Winfield Sale
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase.
Liu D, Vleugel M, …, Cheeseman IM, Lampson MA
J Cell Biol 2010 Mar 15 [abstract on PubMed] [related articles] [full text]
Selected by | Vincent Vanoosthuyse and Kevin Hardwick
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.
Beck H, Nähse V, …, Syljuåsen RG, Sørensen CS
J Cell Biol 2010 Mar 8 188(5):629-38 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Etienne Schwob
Evaluated 18 Mar 2010

Exceptional
F1000 Factor 9.0

Tech Advance
 Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites.
Schilling O, Overall CM
Nat Biotechnol 2008 Jun 26(6):685-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Morten Meldal
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

Tech Advance
 Photoreversible DNA end capping for the formation of hairpin structures.
Yoshimura Y, Okada H, Fujimoto K
Org Biomol Chem 2010 8:1523-26 [full text]
Selected by | Scott K Silverman
Evaluated 18 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
 Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.
Niakan KK, Ji H, …, McMahon AP, Eggan K
Genes Dev 2010 Feb 1 24(3):312-26 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mathias Francois and Peter Koopman
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Arabidopsis thaliana life without phytochromes.
Strasser B, Sánchez-Lamas M, …, Casal JJ, Cerdán PD
Proc Natl Acad Sci U S A 2010 Mar 9 107(10):4776-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christian Hardtke
Evaluated 18 Mar 2010

Must Read
F1000 Factor 6.0

Tech Advance
Refutation
 Preferential ethanol consumption in Drosophila models features of addiction.
Devineni AV, Heberlein U
Curr Biol 2009 Dec 29 19(24):2126-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rainer Spanagel
Evaluated 18 Mar 2010

Exceptional
F1000 Factor 9.0

New Finding
 Closthioamide: An Unprecedented Polythioamide Antibiotic from the Strictly Anaerobic Bacterium Clostridium cellulolyticum.
Lincke T, Behnken S, …, Roth M, Hertweck C
Angew Chem Int Ed Engl 2010 Mar 8 49(11):2011-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolfgang Buckel
Evaluated 17 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination.
Dugas JC, Cuellar TL, …, McManus MT, Barres BA
Neuron 2010 Mar 11 65(5):597-611 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Barbara Hempstead
Evaluated 17 Mar 2010


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