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Must Read
F1000 Factor 6.0

New Finding
 MONOPTEROS controls embryonic root initiation by regulating a mobile transcription factor.
Schlereth A, Möller B, …, Jürgens G, Weijers D
Nature 2010 Mar 10 [abstract on PubMed] [related articles] [full text]
Selected by | Rüdiger Simon
Evaluated 12 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
 Education of human natural killer cells by activating killer cell immunoglobulin-like receptors.
Fauriat C, Ivarsson MA, …, Malmberg KJ, Michaëlsson J
Blood 2010 Feb 11 115(6):1166-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Aurélie Poli and Jacques Zimmer
Evaluated 12 Mar 2010

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Transcriptional control of gene expression by microRNAs.
Khraiwesh B, Arif MA, …, Reski R, Frank W
Cell 2010 Jan 8 140(1):111-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Irina Haecker and Rolf Renne
Evaluated 12 Mar 2010

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
 The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc.
Greer PL, Hanayama R, …, Steen J, Greenberg ME
Cell 2010 Mar 5 140(5):704-716 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Karl-Peter Giese
Evaluated 12 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
 Epigenetic inheritance of an inducibly nucleosome-depleted promoter and its associated transcriptional state in the apparent absence of transcriptional activators.
Ohsawa R, Adkins M, Tyler JK
Epigenetics Chromatin 2009 2(1):11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fyodor Urnov
Evaluated 12 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Blueprint for antimicrobial hit discovery targeting metabolic networks.
Shen Y, Liu J, …, Wiest O, Oltvai ZN
Proc Natl Acad Sci U S A 2010 Jan 19 107(3):1082-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 11 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 Distinct protein domains and expression patterns confer divergent axon guidance functions for Drosophila Robo receptors.
Spitzweck B, Brankatschk M, Dickson BJ
Cell 2010 Feb 5 140(3):409-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Talila Volk
Evaluated 11 Mar 2010

Recommended
F1000 Factor 3.0

Confirmation
 Noise can induce bimodality in positive transcriptional feedback loops without bistability.
To TL, Maheshri N
Science 2010 Feb 26 327(5969):1142-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jeffrey Axelrod
Evaluated 11 Mar 2010

Must Read
F1000 Factor 6.4

Confirmation
Hypothesis
New Finding
Novel Drug Target
 FcRgamma activation regulates inflammation-associated squamous carcinogenesis.
Andreu P, Johansson M, …, De Palma M, Coussens LM
Cancer Cell 2010 Feb 17 17(2):121-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Xiaojing Ma / Friedemann Kiefer
Evaluated 11 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations.
Lauring J, Cosgrove DP, …, Buckhaults PJ, Park BH
Oncogene 2010 Jan 25 [abstract on PubMed] [related articles] [full text]
Selected by | Maria Mancini and Alex Toker
Evaluated 11 Mar 2010


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