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F1000 Factor 3.0

New Finding
Tech Advance
 Annotation error in public databases: misannotation of molecular function in enzyme superfamilies.
Schnoes AM, Brown SD, Dodevski I, Babbitt PC
PLoS Comput Biol 2009 Dec 5(12):e1000605 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Matthew Hahn
Evaluated 9 Feb 2010

Must Read
F1000 Factor 6.0

New Finding
 Origins and functional impact of copy number variation in the human genome.
Conrad DF, Pinto D, …, Scherer SW, Hurles ME
Nature 2009 Oct 7 [abstract on PubMed] [related articles] [full text]
Selected by | R Frank Kooy
Evaluated 9 Feb 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I.
Puel A, Döffinger R, …, Lilic D, Casanova JL
J Exp Med 2010 Feb 1 [abstract on PubMed] [related articles] [full text]
Selected by | Caetano Reis e Sousa
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines.
Kisand K, Bøe Wolff AS, …, Willcox N, Meager A
J Exp Med 2010 Feb 1 [abstract on PubMed] [related articles] [full text]
Selected by | Caetano Reis e Sousa
Evaluated 8 Feb 2010

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates.
Liu B, Larsson L, …, Grantham J, Nystrom T
Cell 2010 140:257-67 [full text]
Selected by | Andrei Fagarasanu, Fred Mast and Richard Rachubinski
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 Arabidopsis Tic62 and ferredoxin-NADP(H) oxidoreductase form light-regulated complexes that are integrated into the chloroplast redox poise.
Benz JP, Stengel A, …, Soll J, Bölter B
Plant Cell 2009 Dec 21(12):3965-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | H Ekkehard Neuhaus
Evaluated 8 Feb 2010

Exceptional
F1000 Factor 9.0

New Finding
 TRPV2 has a pivotal role in macrophage particle binding and phagocytosis.
Link TM, Park U, …, Soloski MJ, Caterina MJ
Nat Immunol 2010 Jan 31 [abstract on PubMed] [related articles] [full text]
Selected by | Bernd Nilius
Evaluated 8 Feb 2010

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F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction.
Madhur MS, Lob HE, …, Guzik TJ, Harrison DG
Hypertension 2010 Feb 55(2):500-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Imig
Evaluated 8 Feb 2010


Recommended
F1000 Factor 3.0

Hypothesis
Controversial
 The synthesis of truncated polypeptides for immune surveillance and viral evasion.
Cardinaud S, Starck SR, Chandra P, Shastri N
PLoS One 2010 5(1):e8692 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Xiaoli Wang and Ted Hansen
Evaluated 8 Feb 2010

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F1000 Factor 3.0

New Finding
 Elucidation of the complete ferrichrome A biosynthetic pathway in Ustilago maydis.
Winterberg B, Uhlmann S, …, Kahmann R, Schirawski J
Mol Microbiol 2010 Jan 12 [abstract on PubMed] [related articles] [full text]
Selected by | William Holloman
Evaluated 5 Feb 2010


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