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Control of Gene Expression
Nuclear Structure & Function

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Must Read
F1000 Factor 6.0

New Finding
 Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.
Lee JH, Budanov AV, …, Bier E, Karin M
Science 2010 Mar 5 327(5970):1223-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Heinz Osiewacz
Evaluated 19 Mar 2010

Must Read
F1000 Factor 6.0

Confirmation
New Finding
 Histone modification levels are predictive for gene expression.
Karlic R, Chung HR, …, Vlahovicek K, Vingron M
Proc Natl Acad Sci U S A 2010 Feb 16 107(7):2926-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | P Shing Ho
Evaluated 19 Mar 2010

Exceptional
F1000 Factor 9.0

Tech Advance
 Rational design of cationic lipids for siRNA delivery.
Semple SC, Akinc A, …, Madden TD, Hope MJ
Nat Biotechnol 2010 Feb 28(2):172-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rudy Juliano
Evaluated 19 Mar 2010


Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man.
Ravasi T, Suzuki H, …, Ideker T, Hayashizaki Y
Cell 2010 Mar 5 140(5):744-752 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D Sharrocks
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
Min J, Zaslavsky A, …, Loda M, Cichowski K
Nat Med 2010 Mar 16(3):286-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ilaria Esposito and Filippo Giancotti
Evaluated 18 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
 Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase.
Kang T, Lindsey-Boltz LA, Reardon JT, Sancar A
Pro Nat Acad Sci 2010 107:4890-5 [full text]
Selected by | Jennifer Lee and Pengbo Zhou
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity.
Tovy A, Siman Tov R, …, Helm M, Ankri S
PLoS Pathog 2010 6(2):e1000775 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Upinder Singh
Evaluated 18 Mar 2010

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 An essential role for XBP-1 in host protection against immune activation in C. elegans.
Richardson CE, Kooistra T, Kim DH
Nature 2010 Feb 25 463(7284):1092-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Maria Markaki and Nektarios Tavernarakis
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase.
Liu D, Vleugel M, …, Cheeseman IM, Lampson MA
J Cell Biol 2010 Mar 15 [abstract on PubMed] [related articles] [full text]
Selected by | Vincent Vanoosthuyse and Kevin Hardwick
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.
Beck H, Nähse V, …, Syljuåsen RG, Sørensen CS
J Cell Biol 2010 Mar 8 188(5):629-38 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Etienne Schwob
Evaluated 18 Mar 2010


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