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Control of Gene Expression
Nuclear Structure & Function

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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 The effect of replication initiation on gene amplification in the rDNA and its relationship to aging.
Ganley AR, Ide S, Saka K, Kobayashi T
Mol Cell 2009 Sep 11 35(5):683-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lucio Comai
Evaluated 31 Dec 2009

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 A Systems Approach Reveals that the Myogenesis Genome Network Is Regulated by the Transcriptional Repressor RP58
Yokoyama S., Ito Y, …, Hashimoto M., Asahara H.
Developmental Cell 2009 17:836-848 [full text]
Selected by | Robert S Krauss
Evaluated 23 Dec 2009

Must Read
F1000 Factor 6.0

New Finding
 SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.
Zhang X, Lei K, …, Xu R, Han M
Neuron 2009 Oct 29 64(2):173-87 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nicolas Gaspard and Pierre Vanderhaeghen
Evaluated 23 Dec 2009

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Refutation
 RNA polymerase II-TFIIB structure and mechanism of transcription initiation.
Kostrewa D, Zeller ME, …, Thomm M, Cramer P
Nature 2009 Nov 19 462(7271):323-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chantal Abergel
Evaluated 23 Dec 2009

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Interspecific profiling of gene expression informed by comparative genomic hybridization: A review and a novel approach in African cichlid fishes.
Machado HE, Pollen AA, Hofmann HA, Renn SCP
Integr Comp Biol 2009 49:644-58 [full text]
Selected by | Nico M van Straalen
Evaluated 23 Dec 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa.
Oliver PL, Goodstadt L, …, Malik HS, Ponting CP
PLoS Genet 2009 Dec 5(12):e1000753 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Hopi Hoekstra
Evaluated 22 Dec 2009

Must Read
F1000 Factor 6.0

New Finding
 HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.
David CJ, Chen M, …, Canoll P, Manley JL
Nature 2009 Dec 13 [abstract on PubMed] [related articles] [full text]
Selected by | Robert Abraham
Evaluated 22 Dec 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6.
Lippman SI, Broach JR
Proc Natl Acad Sci U S A 2009 Nov 24 106(47):19928-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Malcolm Whiteway
Evaluated 21 Dec 2009

Recommended
F1000 Factor 3.0

New Finding
 Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells.
Pan MR, Chang TM, …, Wang HW, Hung WC
J Cell Sci 2009 Sep 15 122(Pt 18):3358-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Bates
Evaluated 18 Dec 2009

Must Read
F1000 Factor 6.0

New Finding
 Brh2 promotes a template-switching reaction enabling recombinational bypass of lesions during DNA synthesis.
Mazloum N, Holloman WK
Mol Cell 2009 Nov 25 36(4):620-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Carr
Evaluated 18 Dec 2009


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