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Recommended
F1000 Factor 3.0

New Finding
 The C. elegans dosage compensation complex propagates dynamically and independently of X chromosome sequence.
Ercan S, Dick LL, Lieb JD
Curr Biol 2009 Nov 17 19(21):1777-87 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert K Herman
Evaluated 10 Dec 2009

Recommended
F1000 Factor 3.0

New Finding
 A non-canonical DNA structure enables homologous recombination in various genetic systems.
Masuda T, Ito Y, …, Shibata T, Mikawa T
J Biol Chem 2009 Oct 30 284(44):30230-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Holloman
Evaluated 10 Dec 2009

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Evidence for multiple independent origins of trans-splicing in Metazoa.
Douris V, Telford MJ, Averof M
Mol Biol Evol 2009 Nov 25 [abstract on PubMed] [related articles] [full text]
Selected by | Miltos Tsiantis
Evaluated 10 Dec 2009

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Controversial
 Identification of a physiologically relevant endogenous ligand for PPARalpha in liver.
Chakravarthy MV, Lodhi IJ, …, Turk J, Semenkovich CF
Cell 2009 Aug 7 138(3):476-88 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Moore
Evaluated 10 Dec 2009


Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Tech Advance
 A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication.
Evrin C, Clarke P, …, Stillman B, Speck C
Proc Natl Acad Sci U S A 2009 Dec 1 106(48):20240-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joel Huberman
Evaluated 9 Dec 2009

Recommended
F1000 Factor 3.0

New Finding
 The SAND domain protein ULTRAPETALA1 acts as a trithorax group factor to regulate cell fate in plants.
Carles CC, Fletcher JC
Genes Dev 2009 Dec 1 23(23):2723-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Vivian Irish
Evaluated 9 Dec 2009

Recommended
F1000 Factor 3.0

New Finding
 Human RAP1 inhibits non-homologous end joining at telomeres.
Sarthy J, Bae NS, Scrafford J, Baumann P
EMBO J 2009 Nov 4 28(21):3390-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yun Wu and Virginia Zakian
Evaluated 8 Dec 2009

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 An oestrogen-receptor-alpha-bound human chromatin interactome.
Fullwood MJ, Liu MH, …, Cheung E, Ruan Y
Nature 2009 Nov 5 462(7269):58-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Weihong Ge and Yi Eve Sun
Evaluated 8 Dec 2009

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
 Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways.
Sharov AA, Mardaryev AN, …, Dlugosz A, Botchkarev VA
Am J Pathol 2009 Sep 175(3):1303-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stefan Koch and Asma Nusrat
Evaluated 8 Dec 2009

Recommended
F1000 Factor 3.0

New Finding
Controversial
 A Spindle Assembly Checkpoint Protein Functions in Prophase I Arrest and Prometaphase Progression.
Homer H, Gui L, Carroll J
Science 2009 326:991-4 [full text]
Selected by | Marie-Emilie Terret and Marie-Hélène Verlhac
Evaluated 4 Dec 2009


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