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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation.
Fu M, Sato Y, …, Napoli JL, Heuckeroth RO
Development 2010 Feb 137(4):631-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S Eisen
Evaluated 9 Feb 2010

Must Read
F1000 Factor 6.0

Confirmation
New Finding
 Control of heart rate by cAMP sensitivity of HCN channels.
Alig J, Marger L, …, Mangoni ME, Isbrandt D
Proc Natl Acad Sci U S A 2009 Jul 21 106(29):12189-94 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mohammad Shariq Imtiaz and Dirk van Helden
Evaluated 9 Feb 2010

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
 Valproic acid reduces spatial working memory and cell proliferation in the hippocampus.
Umka J, Mustafa S, …, Bennett G, Wigmore PM
Neuroscience 2010 Mar 10 166(1):15-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Sendtner
Evaluated 9 Feb 2010

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Controversial
 Transient receptor potential vanilloid gene deletion exacerbates inflammation and atypical cardiac remodeling after myocardial infarction.
Huang W, Rubinstein J, …, Thang LV, Wang DH
Hypertension 2009 Feb 53(2):243-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael Andresen
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington’s disease mice.
Milnerwood AJ, Gladding CM, …, Murphy TH, Raymond LA
Neuron 2010 65:178-90 [full text]
Selected by | Ana M M Oliveira and Hilmar Bading
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 An investigation of the effects of hippocampal lesions in rats on pre- and postoperatively acquired spatial memory in a complex environment.
Winocur G, Moscovitch M, Rosenbaum RS, Sekeres M
Hippocampus 2010 Jan 6 [abstract on PubMed] [related articles] [full text]
Selected by | Norman White
Evaluated 8 Feb 2010

Must Read
F1000 Factor 6.0

New Finding
 Amyloid beta from axons and dendrites reduces local spine number and plasticity.
Wei W, Nguyen LN, …, Sisodia S, Malinow R
Nat Neurosci 2010 Feb 13(2):190-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Karl-Peter Giese
Evaluated 8 Feb 2010


Recommended
F1000 Factor 3.0

Tech Advance
Novel Drug Target
 Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice.
Rodriguez-Cuenca S, Cochemé HM, …, Smith RA, Murphy MP
Free Radic Biol Med 2010 Jan 1 48(1):161-172 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Harry Ischiropoulos
Evaluated 5 Feb 2010

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 A Genetic Variant BDNF Polymorphism Alters Extinction Learning in Both Mouse and Human.
Soliman F, Glatt CE, …, Lee FS, Casey BJ
Science 2010 Jan 14 [abstract on PubMed] [related articles] [full text]
Selected by | Markus Heilig
Evaluated 5 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 The nuclear experience of CPEB: implications for RNA processing and translational control.
Lin CL, Evans V, …, Xing Y, Richter JD
RNA 2010 Feb 16(2):338-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Roy Long
Evaluated 5 Feb 2010


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