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F1000 Factor 3.0

Confirmation
Hypothesis
 Valproic acid reduces spatial working memory and cell proliferation in the hippocampus.
Umka J, Mustafa S, …, Bennett G, Wigmore PM
Neuroscience 2010 Mar 10 166(1):15-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Sendtner
Evaluated 9 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 A one-pot approach to neoglycopeptides using orthogonal native chemical ligation and click chemistry.
Lee DJ, Mandal K, …, Brimble MA, Kent SB
Org Lett 2009 Nov 19 11(22):5270-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Roger Freidinger
Evaluated 9 Feb 2010

Exceptional
F1000 Factor 9.0

New Finding
 PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice.
Baudat F, Buard J, …, Coop G, de Massy B
Science 2009 Dec 31 [abstract on PubMed] [related articles] [full text]
Selected by | Laurie Stevison and Mohamed Noor
Evaluated 9 Feb 2010

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F1000 Factor 3.0

New Finding
Tech Advance
 Annotation error in public databases: misannotation of molecular function in enzyme superfamilies.
Schnoes AM, Brown SD, Dodevski I, Babbitt PC
PLoS Comput Biol 2009 Dec 5(12):e1000605 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Matthew Hahn
Evaluated 9 Feb 2010

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F1000 Factor 3.0

Tech Advance
Novel Drug Target
 SCAN--a high-throughput assay for detecting small molecule binding to RNA targets.
Baugh C, Wang S, …, Appleman JR, Thompson PA
J Biomol Screen 2009 Mar 14(3):219-29 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stacie Richardson and Anne Baranger
Evaluated 8 Feb 2010

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F1000 Factor 3.0

Hypothesis
New Finding
 Vinculin regulates cell-surface E-cadherin expression by binding to {beta}-catenin.
Peng X, Cuff LE, Lawton CD, Demali KA
J Cell Sci 2010 Jan 19 [abstract on PubMed] [related articles] [full text]
Selected by | Ronen Zaidel-Bar
Evaluated 8 Feb 2010

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F1000 Factor 3.0

Confirmation
New Finding
Refutation
 Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation.
Popp D, Xu W, …, Robinson RC, Schumacher M
J Biol Chem 2010 Jan 27 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 8 Feb 2010

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F1000 Factor 6.0

New Finding
Tech Advance
 A new view of pectin structure revealed by acid hydrolysis and atomic force microscopy.
Round AN, Rigby NM, Macdougall AJ, Morris VJ
Carbohydr Res 2009 Dec 28 [abstract on PubMed] [related articles] [full text]
Selected by | Jocelyn Rose
Evaluated 8 Feb 2010

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F1000 Factor 6.0

Hypothesis
New Finding
 The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates.
Liu B, Larsson L, …, Grantham J, Nystrom T
Cell 2010 140:257-67 [full text]
Selected by | Andrei Fagarasanu, Fred Mast and Richard Rachubinski
Evaluated 8 Feb 2010

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F1000 Factor 3.0

New Finding
Tech Advance
 Mechanistic details of a protein-protein association pathway revealed by paramagnetic relaxation enhancement titration measurements.
Fawzi NL, Doucleff M, Suh JY, Clore GM
Proc Natl Acad Sci U S A 2010 Jan 26 107(4):1379-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mikael Akke
Evaluated 8 Feb 2010


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