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Must Read
F1000 Factor 6.0

New Finding
Tech Advance
Running in reverse: the structural basis for translocation polarity in hexameric helicases.
Thomsen ND, Berger JM
Cell 2009 Oct 30 139(3):523-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Matthew L Bochman and Virginia Zakian
Evaluated 26 Nov 2009

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).
Karreth FA, DeNicola GM, Winter SP, Tuveson DA
Mol Cell 2009 Nov 13 36(3):477-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Simon Cook
Evaluated 26 Nov 2009

Recommended
F1000 Factor 3.0

Tech Advance
High-resolution structural analysis of a DNA nanostructure by cryoEM.
Kato T, Goodman RP, …, Turberfield AJ, Namba K
Nano Lett 2009 Jul 9(7):2747-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Phoebe Stewart
Evaluated 26 Nov 2009

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
Tech Advance
Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation.
Zeqiraj E, Filippi BM, …, Alessi DR, van Aalten DM
Science 2009 Nov 5 [abstract on PubMed] [related articles] [full text]
Selected by | Nathan Nelson
Evaluated 26 Nov 2009

Recommended
F1000 Factor 3.0

Hypothesis
Functional group contributions to drug-receptor interactions.
Andrews PR, Craik DJ, Martin JL
J Med Chem 1984 Dec 27(12):1648-57 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Michne
Evaluated 26 Nov 2009

Recommended
F1000 Factor 3.0

New Finding
Drosophila RecQ4 has a 3'-5' DNA helicase activity that is essential for viability.
Capp C, Wu J, Hsieh TS
J Biol Chem 2009 Nov 6 284(45):30845-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steven Brill
Evaluated 25 Nov 2009

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
Kinetic advantage of intrinsically disordered proteins in coupled folding-binding process: a critical assessment of the "fly-casting" mechanism.
Huang Y, Liu Z
J Mol Biol 2009 Nov 13 393(5):1143-59 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Vladimir Uversky
Evaluated 25 Nov 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Novel Drug Target
Suppression of cancer cell growth by promoting cyclin D1 degradation.
Shan J, Zhao W, Gu W
Mol Cell 2009 Nov 13 36(3):469-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philipp Kaldis
Evaluated 25 Nov 2009

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
Insights into how nucleotide-binding domains power ABC transport.
Newstead S, Fowler PW, …, Sansom MS, Iwata S
Structure 2009 Sep 9 17(9):1213-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hendrik W van Veen
Evaluated 25 Nov 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Dynamic interactions and cooperative functions of PGC-1alpha and MED1 in TRalpha-mediated activation of the brown-fat-specific UCP-1 gene.
Chen W, Yang Q, Roeder RG
Mol Cell 2009 Sep 24 35(6):755-68 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Webb
Evaluated 25 Nov 2009


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