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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Controversial
 Transient receptor potential vanilloid gene deletion exacerbates inflammation and atypical cardiac remodeling after myocardial infarction.
Huang W, Rubinstein J, …, Thang LV, Wang DH
Hypertension 2009 Feb 53(2):243-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael Andresen
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington’s disease mice.
Milnerwood AJ, Gladding CM, …, Murphy TH, Raymond LA
Neuron 2010 65:178-90 [full text]
Selected by | Ana M M Oliveira and Hilmar Bading
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

Tech Advance
Novel Drug Target
 SCAN--a high-throughput assay for detecting small molecule binding to RNA targets.
Baugh C, Wang S, …, Appleman JR, Thompson PA
J Biomol Screen 2009 Mar 14(3):219-29 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stacie Richardson and Anne Baranger
Evaluated 8 Feb 2010

Must Read
F1000 Factor 6.0

New Finding
 Amyloid beta from axons and dendrites reduces local spine number and plasticity.
Wei W, Nguyen LN, …, Sisodia S, Malinow R
Nat Neurosci 2010 Feb 13(2):190-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Karl-Peter Giese
Evaluated 8 Feb 2010


Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Vinculin regulates cell-surface E-cadherin expression by binding to {beta}-catenin.
Peng X, Cuff LE, Lawton CD, Demali KA
J Cell Sci 2010 Jan 19 [abstract on PubMed] [related articles] [full text]
Selected by | Ronen Zaidel-Bar
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis.
Wang Q, Uhlirova M, Bohmann D
Dev Cell 2010 18:157-64 [full text]
Selected by | Talila Volk
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch.
Dhillon AS, Yip YY, …, Mischak H, Kolch W
Cell Signal 2009 Nov 21(11):1645-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chris Udell and Marc Therrien
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 A rho scaffold integrates the secretory system with feedback mechanisms in regulation of auxin distribution.
Hazak O, Bloch D, …, Friml J, Yalovsky S
PLoS Biol 2010 8(1):e1000282 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jan Traas
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Refutation
 Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation.
Popp D, Xu W, …, Robinson RC, Schumacher M
J Biol Chem 2010 Jan 27 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 8 Feb 2010

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 A new view of pectin structure revealed by acid hydrolysis and atomic force microscopy.
Round AN, Rigby NM, Macdougall AJ, Morris VJ
Carbohydr Res 2009 Dec 28 [abstract on PubMed] [related articles] [full text]
Selected by | Jocelyn Rose
Evaluated 8 Feb 2010


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