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Must Read
F1000 Factor 6.0

New Finding
 Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.
Lee JH, Budanov AV, …, Bier E, Karin M
Science 2010 Mar 5 327(5970):1223-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Heinz Osiewacz
Evaluated 19 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 Salicylic acid stimulates secretion of the normally symplastic enzyme mannitol dehydrogenase: a possible defense against mannitol-secreting fungal pathogens.
Cheng FY, Zamski E, …, Pharr DM, Williamson JD
Planta 2009 Nov 230(6):1093-103 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steven Huber
Evaluated 19 Mar 2010

Must Read
F1000 Factor 6.0

Confirmation
New Finding
 Histone modification levels are predictive for gene expression.
Karlic R, Chung HR, …, Vlahovicek K, Vingron M
Proc Natl Acad Sci U S A 2010 Feb 16 107(7):2926-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | P Shing Ho
Evaluated 19 Mar 2010

Must Read
F1000 Factor 6.0

Confirmation
 Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons.
Dubreuil V, Thoby-Brisson M, …, Fortin G, Goridis C
J Neurosci 2009 Nov 25 29(47):14836-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Donald McCrimmon
Evaluated 19 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
 Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux.
Wang Q, Zhang Y, …, Zhao S, Zhao GP
Science 2010 Feb 19 327(5968):1004-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Adrian Mehlitz and Roy Gross
Evaluated 19 Mar 2010

Must Read
F1000 Factor 6.0

Confirmation
New Finding
 Math1 is essential for the development of hindbrain neurons critical for perinatal breathing.
Rose MF, Ren J, …, Greer JJ, Zoghbi HY
Neuron 2009 Nov 12 64(3):341-54 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Donald McCrimmon
Evaluated 19 Mar 2010

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Somatic sex identity is cell autonomous in the chicken.
Zhao D, McBride D, …, Sang HM, Clinton M
Nature 2010 Mar 11 464(7286):237-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Craig Smith and Andrew Sinclair
Evaluated 19 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 Embryo and Endosperm Inherit Distinct Chromatin and Transcriptional States from the Female Gametes in Arabidopsis.
Pillot M, Baroux C, …, Grossniklaus U, Grimanelli D
Plant Cell 2010 Feb 5 [abstract on PubMed] [related articles] [full text]
Selected by | David Smyth
Evaluated 19 Mar 2010

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Tech Advance
 Loss of Aip1 reveals a role in maintaining the actin monomer pool and an in vivo oligomer assembly pathway.
Okreglak V, Drubin DG
J Cell Biol 2010 Mar 15 [abstract on PubMed] [related articles] [full text]
Selected by | Pekka Lappalainen
Evaluated 19 Mar 2010

Exceptional
F1000 Factor 9.0

Tech Advance
 Rational design of cationic lipids for siRNA delivery.
Semple SC, Akinc A, …, Madden TD, Hope MJ
Nat Biotechnol 2010 Feb 28(2):172-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rudy Juliano
Evaluated 19 Mar 2010



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