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F1000 Factor 3.0

Hypothesis
New Finding
 Evidence that electrostatic interactions between vesicle-associated membrane protein 2 and acidic phospholipids may modulate the fusion of transport vesicles with the plasma membrane.
Williams D, Vicôgne J, …, McLaughlin S, Pessin JE
Mol Biol Cell 2009 Dec 20(23):4910-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Cafiso
Evaluated 31 Dec 2009

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F1000 Factor 6.0

Hypothesis
New Finding
 Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning.
Aras MA, Hara H, …, Kandler K, Aizenman E
J Neurochem 2009 Jul 110(1):106-17 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bruce Pitt
Evaluated 30 Dec 2009

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F1000 Factor 3.0

New Finding
 Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis.
Lin Y, Ritchea S, …, Kolls JK, Khader SA
Immunity 2009 Nov 20 31(5):799-810 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Mansfield
Evaluated 30 Dec 2009

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F1000 Factor 6.0

Hypothesis
New Finding
 Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.
Schmaier AA, Zou Z, …, Saksela K, Kahn ML
Proc Natl Acad Sci U S A 2009 Dec 15 106(50):21167-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steve Watson
Evaluated 30 Dec 2009

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F1000 Factor 6.0

New Finding
 Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex.
Giorgio V, Bisetto E, …, Bernardi P, Lippe G
J Biol Chem 2009 Dec 4 284(49):33982-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Heinz Osiewacz
Evaluated 30 Dec 2009

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F1000 Factor 6.0

New Finding
 Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation.
Fannin RD, Russo M, …, Watkins PB, Paules RS
Hepatology 2009 Sep 25 51(1):227-236 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Burcham
Evaluated 29 Dec 2009

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F1000 Factor 3.0

Hypothesis
 Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity.
Yang L, Wang Z, …, Justice NJ, Zheng H
J Neurosci 2009 Dec 16 29(50):15660-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Surmeier
Evaluated 29 Dec 2009

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F1000 Factor 3.0

Hypothesis
New Finding
 Statins impair CD1d-mediated antigen presentation through the inhibition of prenylation.
Khan MA, Gallo RM, …, Gervay-Hague J, Brutkiewicz RR
J Immunol 2009 Apr 15 182(8):4744-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alex Moise and Wilfred Jefferies
Evaluated 24 Dec 2009

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F1000 Factor 6.0

Confirmation
Controversial
 A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation.
Hayashi-Nishino M, Fujita N, …, Yoshimori T, Yamamoto A
Nat Cell Biol 2009 Dec 11(12):1433-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kerstin Radtke and Michel Desjardins
Evaluated 23 Dec 2009

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F1000 Factor 3.0

New Finding
Tech Advance
 A Systems Approach Reveals that the Myogenesis Genome Network Is Regulated by the Transcriptional Repressor RP58
Yokoyama S., Ito Y, …, Hashimoto M., Asahara H.
Developmental Cell 2009 17:836-848 [full text]
Selected by | Robert S Krauss
Evaluated 23 Dec 2009


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