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Must Read
F1000 Factor 6.0

Tech Advance
A human gut microbial gene catalogue established by metagenomic sequencing.
Qin J, Li R, …, Ehrlich SD, Wang J
Nature 2010 Mar 4 464(7285):59-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Anforra and Scott Lesley
Evaluated 22 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
Metabolic Autocrine Regulation of Neurons Involves Cooperation among Pannexin Hemichannels, Adenosine Receptors, and KATP Channels.
Kawamura M, Ruskin DN, Masino SA
J Neurosci 2010 Mar 17 30(11):3886-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Eric Nestler
Evaluated 22 Mar 2010

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site.
Letellier E, Kumar S, …, Karray S, Martin-Villalba A
Immunity 2010 Feb 26 32(2):240-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Juan Rivera
Evaluated 22 Mar 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Novel Drug Target
Regulation of leukocyte recruitment by the long pentraxin PTX3.
Deban L, Russo RC, …, Bottazzi B, Mantovani A
Nat Immunol 2010 Apr 11(4):328-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Xingfeng Bao and Minoru Fukuda
Evaluated 22 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex.
Burgos PV, Mardones GA, …, Hurley JH, Bonifacino JS
Dev Cell 2010 Mar 16 18(3):425-436 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Mayinger
Evaluated 22 Mar 2010

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Kinetochores generate microtubules with distal plus ends: their roles and limited lifetime in mitosis.
Kitamura E, Tanaka K, …, Antony C, Tanaka TU
Dev Cell 2010 Feb 16 18(2):248-59 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mary Dasso
Evaluated 22 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy.
Yen WL, Shintani T, …, Baba M, Klionsky DJ
J Cell Biol 2010 Jan 11 188(1):101-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fulvio Reggiori and Judith Klumperman
Evaluated 22 Mar 2010

Exceptional
F1000 Factor 9.0

New Finding
A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response.
Ashida H, Kim M, …, Ogawa M, Sasakawa C
Nat Cell Biol 2010 Jan 12(1):66-73; sup pp 1-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mélanie Hamon and Pascale Cossart
Evaluated 22 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.
Lee JH, Budanov AV, …, Bier E, Karin M
Science 2010 Mar 5 327(5970):1223-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Heinz Osiewacz
Evaluated 19 Mar 2010

Must Read
F1000 Factor 6.0

Confirmation
Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons.
Dubreuil V, Thoby-Brisson M, …, Fortin G, Goridis C
J Neurosci 2009 Nov 25 29(47):14836-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Donald McCrimmon
Evaluated 19 Mar 2010


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