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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation.
Fu M, Sato Y, …, Napoli JL, Heuckeroth RO
Development 2010 Feb 137(4):631-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S Eisen
Evaluated 9 Feb 2010

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
 Valproic acid reduces spatial working memory and cell proliferation in the hippocampus.
Umka J, Mustafa S, …, Bennett G, Wigmore PM
Neuroscience 2010 Mar 10 166(1):15-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Sendtner
Evaluated 9 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 A one-pot approach to neoglycopeptides using orthogonal native chemical ligation and click chemistry.
Lee DJ, Mandal K, …, Brimble MA, Kent SB
Org Lett 2009 Nov 19 11(22):5270-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Roger Freidinger
Evaluated 9 Feb 2010

Exceptional
F1000 Factor 9.0

New Finding
 PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice.
Baudat F, Buard J, …, Coop G, de Massy B
Science 2009 Dec 31 [abstract on PubMed] [related articles] [full text]
Selected by | Laurie Stevison and Mohamed Noor
Evaluated 9 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Annotation error in public databases: misannotation of molecular function in enzyme superfamilies.
Schnoes AM, Brown SD, Dodevski I, Babbitt PC
PLoS Comput Biol 2009 Dec 5(12):e1000605 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Matthew Hahn
Evaluated 9 Feb 2010

Must Read
F1000 Factor 6.0

New Finding
 Origins and functional impact of copy number variation in the human genome.
Conrad DF, Pinto D, …, Scherer SW, Hurles ME
Nature 2009 Oct 7 [abstract on PubMed] [related articles] [full text]
Selected by | R Frank Kooy
Evaluated 9 Feb 2010

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Controversial
 Transient receptor potential vanilloid gene deletion exacerbates inflammation and atypical cardiac remodeling after myocardial infarction.
Huang W, Rubinstein J, …, Thang LV, Wang DH
Hypertension 2009 Feb 53(2):243-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael Andresen
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington’s disease mice.
Milnerwood AJ, Gladding CM, …, Murphy TH, Raymond LA
Neuron 2010 65:178-90 [full text]
Selected by | Ana M M Oliveira and Hilmar Bading
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I.
Puel A, Döffinger R, …, Lilic D, Casanova JL
J Exp Med 2010 Feb 1 [abstract on PubMed] [related articles] [full text]
Selected by | Caetano Reis e Sousa
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines.
Kisand K, Bøe Wolff AS, …, Willcox N, Meager A
J Exp Med 2010 Feb 1 [abstract on PubMed] [related articles] [full text]
Selected by | Caetano Reis e Sousa
Evaluated 8 Feb 2010


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