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Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Tech Advance
 Loss of Aip1 reveals a role in maintaining the actin monomer pool and an in vivo oligomer assembly pathway.
Okreglak V, Drubin DG
J Cell Biol 2010 Mar 15 [abstract on PubMed] [related articles] [full text]
Selected by | Pekka Lappalainen
Evaluated 19 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Structure-Activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-Resistant Prostate Cancer (CRPC).
Jung ME, Ouk S, …, Tran C, Wongvipat J
J Med Chem 2010 Mar 10 [abstract on PubMed] [related articles] [full text]
Selected by | Robert Fecik
Evaluated 19 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 Regulation of Cytokinesis by the Formin cdc12p.
Yonetani A, Chang F
Curr Biol 2010 Mar 10 [abstract on PubMed] [related articles] [full text]
Selected by | Mohan Balasubramanian
Evaluated 19 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
Min J, Zaslavsky A, …, Loda M, Cichowski K
Nat Med 2010 Mar 16(3):286-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ilaria Esposito and Filippo Giancotti
Evaluated 18 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
 Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase.
Kang T, Lindsey-Boltz LA, Reardon JT, Sancar A
Pro Nat Acad Sci 2010 107:4890-5 [full text]
Selected by | Jennifer Lee and Pengbo Zhou
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase.
Liu D, Vleugel M, …, Cheeseman IM, Lampson MA
J Cell Biol 2010 Mar 15 [abstract on PubMed] [related articles] [full text]
Selected by | Vincent Vanoosthuyse and Kevin Hardwick
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.
Beck H, Nähse V, …, Syljuåsen RG, Sørensen CS
J Cell Biol 2010 Mar 8 188(5):629-38 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Etienne Schwob
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.
Aronov AM, Tang Q, …, ter Haar E, Xie X
J Med Chem 2009 Oct 22 52(20):6362-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Xiaohua Huang and Gerald Shipps
Evaluated 18 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
 Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells.
Lapensee EW, Lapensee CR, …, Afton S, Ben-Jonathan N
Cancer Lett 2010 Apr 28 290(2):167-173 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin van den Berg
Evaluated 16 Mar 2010

Must Read
F1000 Factor 6.0

Confirmation
New Finding
 Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression.
Yamaguchi T, Cubizolles F, …, Seiser C, Matthias P
Genes Dev 2010 Mar 1 24(5):455-69 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 16 Mar 2010


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