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F1000 Factor 3.0

Confirmation
New Finding
Calcium and Cyclic AMP Promote Axonal Regeneration in Caenorhabditis elegans and Require DLK-1 Kinase.
Ghosh-Roy A, Wu Z, …, Jin Y, Chisholm AD
J Neurosci 2010 Mar 3 30(9):3175-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Burgess
Evaluated 11 Mar 2010

Recommended
F1000 Factor 3.0

Confirmation
Noise can induce bimodality in positive transcriptional feedback loops without bistability.
To TL, Maheshri N
Science 2010 Feb 26 327(5969):1142-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jeffrey Axelrod
Evaluated 11 Mar 2010

Must Read
F1000 Factor 6.4

Confirmation
Hypothesis
New Finding
Novel Drug Target
FcRgamma activation regulates inflammation-associated squamous carcinogenesis.
Andreu P, Johansson M, …, De Palma M, Coussens LM
Cancer Cell 2010 Feb 17 17(2):121-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Xiaojing Ma / Friedemann Kiefer
Evaluated 11 Mar 2010

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
The peroxisomal importomer constitutes a large and highly dynamic pore.
Meinecke M, Cizmowski C, …, Wagner R, Erdmann R
Nat Cell Biol 2010 Mar 12(3):273-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joseph Faust and James McNew
Evaluated 11 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations.
Lauring J, Cosgrove DP, …, Buckhaults PJ, Park BH
Oncogene 2010 Jan 25 [abstract on PubMed] [related articles] [full text]
Selected by | Maria Mancini and Alex Toker
Evaluated 11 Mar 2010

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.
Rajagopal S, Kim J, …, Gerard C, Lefkowitz RJ
Proc Natl Acad Sci U S A 2010 Jan 12 107(2):628-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Brett Adams
Evaluated 11 Mar 2010

Exceptional
F1000 Factor 9.0

Confirmation
New Finding
Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.
Kawashima SA, Yamagishi Y, …, Ishiguro K, Watanabe Y
Science 2010 Jan 8 327(5962):172-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gerben Vader and Rene Medema
Evaluated 11 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
Kibra functions as a tumor suppressor protein that regulates hippo signaling in conjunction with Merlin and expanded.
Yu J, Zheng Y, …, Deng WM, Pan D
Dev Cell 2010 Feb 16 18(2):288-99 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Katrin Hahn and Aurelio Teleman
Evaluated 11 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
Controversial
Control of Rhodopsin's Active Lifetime by Arrestin-1 Expression in Mammalian Rods.
Gross OP, Burns ME
J Neurosci 2010 Mar 3 30(9):3450-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gordon Fain
Evaluated 11 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration.
Shea KL, Xiang W, …, Basson MA, Brack AS
Cell Stem Cell 2010 Feb 5 6(2):117-29 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Keren Bismuth and David Sassoon
Evaluated 11 Mar 2010


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