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19-Mar-2010

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	Exceptional
F1000 Factor 9.0

Tech Advance

Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites.
Schilling O, Overall CM
Nat Biotechnol 2008 Jun 26(6):685-94 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Morten Meldal

Evaluated 18 Mar 2010

	Recommended
F1000 Factor 3.0

Tech Advance

In-gel protein phosphatase assay using fluorogenic substrates.
Kameshita I, Baba H, Umeda Y, Sueyoshi N
Anal Biochem 2010 May 1 400(1):118-122 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Amy Barrios

Evaluated 17 Mar 2010

	Recommended
F1000 Factor 3.0

New Finding

Novel Drug Target

Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity.
Catalán V, Gómez-Ambrosi J, …, Salvador J, Frühbeck G
Nutr Metab Cardiovasc Dis 2010 Jan 25 [abstract on PubMed] [related articles] [full text]

Selected by | David Alpers

Evaluated 17 Mar 2010

	Exceptional
F1000 Factor 9.0

New Finding

Closthioamide: An Unprecedented Polythioamide Antibiotic from the Strictly Anaerobic Bacterium Clostridium cellulolyticum.
Lincke T, Behnken S, …, Roth M, Hertweck C
Angew Chem Int Ed Engl 2010 Mar 8 49(11):2011-3 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Wolfgang Buckel

Evaluated 17 Mar 2010

	Recommended
F1000 Factor 3.0

New Finding

Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli.
Anjem A, Varghese S, Imlay JA
Mol Microbiol 2009 May 72(4):844-58 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Chris Kristich and John Kirby

Evaluated 17 Mar 2010

	Recommended
F1000 Factor 3.0

Hypothesis

New Finding

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.
Cantó C, Jiang LQ, …, Zierath JR, Auwerx J
Cell Metab 2010 Mar 3 11(3):213-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Anthony Means

Evaluated 17 Mar 2010

	Must Read
F1000 Factor 6.0

New Finding

Controversial

The three-dimensional structure of [NiFeSe] hydrogenase from Desulfovibrio vulgaris Hildenborough: a hydrogenase without a bridging ligand in the active site in its oxidised, "as-isolated" state.
Marques MC, Coelho R, …, Pereira IA, Matias PM
J Mol Biol 2010 Mar 5 396(4):893-907 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Crisjoe Joseph and Michael Maroney

Evaluated 17 Mar 2010

	Must Read
F1000 Factor 6.0

Confirmation

Hypothesis

New Finding

Tech Advance

Pathway of ATP utilization and duplex rRNA unwinding by the DEAD-box helicase, DbpA.
Henn A, Cao W, …, Hackney DD, De La Cruz EM
Proc Natl Acad Sci U S A 2010 Mar 2 107(9):4046-50 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Kathleen Hall

Evaluated 15 Mar 2010

	Recommended
F1000 Factor 3.0

New Finding

Tech Advance

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones.
Jewett JC, Sletten EM, Bertozzi CR
J Am Chem Soc 2010 Feb 26 [abstract on PubMed] [related articles] [full text]

Selected by | Julia Gavrilyuk and Carlos F Barbas

Evaluated 15 Mar 2010

	Exceptional
F1000 Factor 9.0

New Finding

Reprogramming towards pluripotency requires AID-dependent DNA demethylation.
Bhutani N, Brady JJ, …, Corbel SY, Blau HM
Nature 2010 Feb 25 463(7284):1042-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Naga Rama Kothapalli and Sebastian Fugmann

Evaluated 15 Mar 2010

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