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F1000 Factor 3.0

Hypothesis

New Finding

Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase.
Liu D, Vleugel M, …, Cheeseman IM, Lampson MA
J Cell Biol 2010 Mar 15 [abstract on PubMed] [related articles] [full text]

Selected by | Vincent Vanoosthuyse and Kevin Hardwick

Evaluated 18 Mar 2010

	Recommended
F1000 Factor 3.0

Tech Advance

Photoreversible DNA end capping for the formation of hairpin structures.
Yoshimura Y, Okada H, Fujimoto K
Org Biomol Chem 2010 8:1523-26 [full text]

Selected by | Scott K Silverman

Evaluated 18 Mar 2010

	Recommended
F1000 Factor 3.0

Hypothesis

New Finding

Bicarbonate secretion of mouse cholangiocytes involves Na(+)-HCO(3) (-) cotransport in addition to Na(+)-independent Cl(-)/HCO(3) (-) exchange.
Uriarte I, Banales JM, …, Prieto J, Medina JF
Hepatology 2009 Oct 23 51(3):891-902 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Bruno Stieger

Evaluated 18 Mar 2010

	Recommended
F1000 Factor 3.0

Tech Advance

In-gel protein phosphatase assay using fluorogenic substrates.
Kameshita I, Baba H, Umeda Y, Sueyoshi N
Anal Biochem 2010 May 1 400(1):118-122 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Amy Barrios

Evaluated 17 Mar 2010

	Recommended
F1000 Factor 3.0

New Finding

Tech Advance

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones.
Jewett JC, Sletten EM, Bertozzi CR
J Am Chem Soc 2010 Feb 26 [abstract on PubMed] [related articles] [full text]

Selected by | Julia Gavrilyuk and Carlos F Barbas

Evaluated 15 Mar 2010

	Recommended
F1000 Factor 3.0

Tech Advance

Tracking Flavin Conformations in Protein Crystal Structures with Raman Spectroscopy and QM/MM Calculations.
Røhr AK, Hersleth HP, Andersson KK
Angew Chem Int Ed Engl 2010 Feb 24 [abstract on PubMed] [related articles] [full text]

Selected by | Andrea Mattevi

Evaluated 15 Mar 2010

	Must Read
F1000 Factor 6.0

New Finding

Spatial control of EGF receptor activation by reversible dimerization on living cells.
Chung I, Akita R, …, Schlessinger J, Mellman I
Nature 2010 Mar 7 [abstract on PubMed] [related articles] [full text]

Selected by | Kermit Carraway

Evaluated 15 Mar 2010

	Recommended
F1000 Factor 3.0

Tech Advance

Ultrahigh-throughput screening in drop-based microfluidics for directed evolution.
Agresti JJ, Antipov E, …, Griffiths AD, Weitz DA
Proc Natl Acad Sci U S A 2010 Mar 2 107(9):4004-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Petr Capek and Michal Lebl
Evaluated 12 Mar 2010

	Recommended
F1000 Factor 3.0

New Finding

Controversial

Control of Rhodopsin's Active Lifetime by Arrestin-1 Expression in Mammalian Rods.
Gross OP, Burns ME
J Neurosci 2010 Mar 3 30(9):3450-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Gordon Fain
Evaluated 11 Mar 2010

	Recommended
F1000 Factor 3.0

New Finding

Controversial

Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation.
Fogal V, Richardson AD, …, Smith JW, Ruoslahti E
Mol Cell Biol 2010 Mar 30(6):1303-18 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Robert Kuchta
Evaluated 11 Mar 2010

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