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Exceptional
F1000 Factor 9.0

Tech Advance
 Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites.
Schilling O, Overall CM
Nat Biotechnol 2008 Jun 26(6):685-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Morten Meldal
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

Tech Advance
 Photoreversible DNA end capping for the formation of hairpin structures.
Yoshimura Y, Okada H, Fujimoto K
Org Biomol Chem 2010 8:1523-26 [full text]
Selected by | Scott K Silverman
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones.
Jewett JC, Sletten EM, Bertozzi CR
J Am Chem Soc 2010 Feb 26 [abstract on PubMed] [related articles] [full text]
Selected by | Julia Gavrilyuk and Carlos F Barbas
Evaluated 15 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Tech Advance
 Intercalation as a means to suppress cyclization and promote polymerization of base-pairing oligonucleotides in a prebiotic world.
Horowitz ED, Engelhart AE, …, Lynn DG, Hud NV
Proc Natl Acad Sci U S A 2010 Mar 8 [abstract on PubMed] [related articles] [full text]
Selected by | Dev P Arya
Evaluated 15 Mar 2010

Must Read
F1000 Factor 6.0

Tech Advance
 Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates.
Carter CF, Baxendale IR, …, Pavey JB, Ley SV
Org Biomol Chem 2009 Nov 21 7(22):4594-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christina M Thompson and Stevan Djuric
Evaluated 11 Mar 2010

Recommended
F1000 Factor 3.0

Tech Advance
 Engineering of Bacillus lipase by directed evolution for enhanced thermal stability: effect of isoleucine to threonine mutation at protein surface.
Khurana J, Singh R, Kaur J
Mol Biol Rep 2010 Feb 3 [abstract on PubMed] [related articles] [full text]
Selected by | Alexander Krichevsky and Vitaly Citovsky
Evaluated 10 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 Conservative secondary structure motif of streptavidin-binding aptamers generated by different laboratories.
Bing T, Yang X, …, Cao Z, Shangguan D
Bioorg Med Chem 2010 Jan 28 18 [abstract on PubMed] [related articles] [full text]
Selected by | Scott K Silverman
Evaluated 10 Mar 2010

Must Read
F1000 Factor 6.0

Tech Advance
 Organelle-Targetable Fluorescent Probes for Imaging Hydrogen Peroxide in Living Cells via SNAP-Tag Protein Labeling.
Srikun D, Albers AE, …, Iavarone AT, Chang CJ
J Am Chem Soc 2010 Mar 4 [abstract on PubMed] [related articles] [full text]
Selected by | Amy Barrios
Evaluated 10 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.
Teng L, Zhao J, …, Ma L, Pei G
Cell Res 2010 Feb 20(2):138-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joel Bockaert
Evaluated 9 Mar 2010

Exceptional
F1000 Factor 8.0

New Finding
Tech Advance
 Active site remodelling accompanies thioester bond formation in the SUMO E1.
Olsen SK, Capili AD, …, Tan DS, Lima CD
Nature 2010 Feb 18 463(7283):906-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Walter Chazin / Michael Rape
First evaluation 9 Mar 2010 | Latest evaluation 15 Mar 2010


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