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F1000 Factor 3.0

Confirmation
New Finding
 Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2.
Liao XH, Buggey J, Kimmel AR
J Cell Sci 2010 Mar 15 123(Pt 6):983-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jeffrey Williams
Evaluated 18 Mar 2010

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F1000 Factor 6.0

Hypothesis
New Finding
 The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella.
Lechtreck KF, Johnson EC, …, Ikebe M, Witman GB
J Cell Biol 2009 Dec 28 187(7):1117-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Maureen Wirschell and Winfield Sale
Evaluated 18 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
 Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.
Niakan KK, Ji H, …, McMahon AP, Eggan K
Genes Dev 2010 Feb 1 24(3):312-26 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mathias Francois and Peter Koopman
Evaluated 18 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration.
Li JP, Fu YN, Chen YR, Tan TH
J Biol Chem 2010 Feb 19 285(8):5472-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony J Baucum II and Brian Wadzinski
Evaluated 17 Mar 2010

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F1000 Factor 6.0

New Finding
 Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.
Tischfield MA, Baris HN, …, Pellman D, Engle EC
Cell 2010 Jan 8 140(1):74-87 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart Feinstein
Evaluated 17 Mar 2010

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F1000 Factor 6.0

Hypothesis
New Finding
 Lack of CXC Chemokine Receptor 3 Signaling Leads to Hypertrophic and Hypercellular Scarring.
Yates CC, Krishna P, …, Turner T, Wells A
Am J Pathol 2010 Mar 4 [abstract on PubMed] [related articles] [full text]
Selected by | Giulio Gabbiani
Evaluated 16 Mar 2010

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F1000 Factor 3.0

Confirmation
New Finding
 Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET.
Matsui T, Leung D, …, Lorincz MC, Shinkai Y
Nature 2010 Feb 17 [abstract on PubMed] [related articles] [full text]
Selected by | Andrea Schorn and Robert Martienssen
Evaluated 16 Mar 2010

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F1000 Factor 6.0

New Finding
 The novel endosomal membrane protein Ema interacts with the class C Vps-HOPS complex to promote endosomal maturation.
Kim S, Wairkar YP, Daniels RW, Diantonio A
J Cell Biol 2010 Mar 8 188(5):717-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anne Spang
Evaluated 15 Mar 2010

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F1000 Factor 3.0

New Finding
 The interaction of angiocidin with tissue transglutaminase.
L'Heureux DZ, Rothman VL, Tuszynski GP
Exp Mol Pathol 2010 Feb 88(1):15-25 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alexey Belkin
Evaluated 15 Mar 2010

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F1000 Factor 3.0

New Finding
 Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia.
Sugiyama Y, Stump RJ, …, Lovicu FJ, McAvoy JW
Dev Biol 2010 Feb 15 338(2):193-201 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jeffrey Axelrod
Evaluated 15 Mar 2010


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