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Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Missense Mutations in the Copper Transporter Gene ATP7A Cause X-Linked Distal Hereditary Motor Neuropathy.
Kennerson ML, Nicholson GA, …, Shy ME, Garbern JY
Am J Hum Genet 2010 Mar 12 86(3):343-352 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony Antonellis
Evaluated 15 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 The Alzheimer's Disease-Associated Amyloid beta-Protein Is an Antimicrobial Peptide.
Soscia SJ, Kirby JE, …, Tanzi RE, Moir RD
PLoS One 2010 5(3):e9505 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Kodadek
Evaluated 15 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 Enzyme-inhibitor-like tuning of Ca(2+) channel connectivity with calmodulin.
Liu X, Yang PS, Yang W, Yue DT
Nature 2010 Feb 18 463(7283):968-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gerald Zamponi
Evaluated 12 Mar 2010

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
 The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc.
Greer PL, Hanayama R, …, Steen J, Greenberg ME
Cell 2010 Mar 5 140(5):704-716 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Karl-Peter Giese
Evaluated 12 Mar 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery in Parkinsonian mice.
Cui YF, Hargus G, …, Schachner M, Bernreuther C
Brain 2010 Jan 133(Pt 1):189-204 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wei-Li Kuan and Roger Barker
Evaluated 11 Mar 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Calcium and Cyclic AMP Promote Axonal Regeneration in Caenorhabditis elegans and Require DLK-1 Kinase.
Ghosh-Roy A, Wu Z, …, Jin Y, Chisholm AD
J Neurosci 2010 Mar 3 30(9):3175-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Burgess
Evaluated 11 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signaling.
Ozkaynak E, Abello G, …, Bermingham JR, Meijer D
J Neurosci 2010 30:3857-3864 [full text]
Selected by | Elior Peles
Evaluated 11 Mar 2010

Recommended
F1000 Factor 3.0

Controversial
 Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling.
Agulhon C, Fiacco TA, McCarthy KD
Science 2010 Mar 5 327(5970):1250-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Erin M Johnson-Venkatesh and Hisashi Umemori
Evaluated 11 Mar 2010

Must Read
F1000 Factor 6.0

Confirmation
New Finding
 R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.
Tong Y, Pisani A, …, Pothos EN, Shen J
Proc Natl Acad Sci U S A 2009 Aug 25 106(34):14622-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wei-Li Kuan and Roger Barker
Evaluated 11 Mar 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.
Tong J, Wong H, …, Hornykiewicz O, Furukawa Y
Brain 2010 Jan 133(Pt 1):172-88 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wei-Li Kuan and Roger Barker
Evaluated 11 Mar 2010


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