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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates.
Liu B, Larsson L, …, Grantham J, Nystrom T
Cell 2010 140:257-67 [full text]
Selected by | Andrei Fagarasanu, Fred Mast and Richard Rachubinski
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Mechanistic details of a protein-protein association pathway revealed by paramagnetic relaxation enhancement titration measurements.
Fawzi NL, Doucleff M, Suh JY, Clore GM
Proc Natl Acad Sci U S A 2010 Jan 26 107(4):1379-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mikael Akke
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Modulation of mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects.
Acin-Perez R, Salazar E, …, Schon EA, Manfredi G
EMBO Mol Med 2009 Nov 1(8-9):392-406 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Eduardo Rial
Evaluated 5 Feb 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility.
Borbulevych OY, Piepenbrink KH, …, Sewell AK, Baker BM
Immunity 2009 Dec 18 31(6):885-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elizabeth L Read, Andrej Košmrlj and Arup Chakraborty
Evaluated 4 Feb 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Transient assembly of F-actin by phagosomes delays phagosome fusion with lysosomes in cargo-overloaded macrophages.
Liebl D, Griffiths G
J Cell Sci 2009 Aug 15 122(Pt 16):2935-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mary Ann McDowell
Evaluated 4 Feb 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Function of the nucleotide exchange activity of vav1 in T cell development and activation.
Saveliev A, Vanes L, …, Rittinger K, Tybulewicz VL
Sci Signal 2009 2(101):ra83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hun Sik Kim and Eric Long
Evaluated 3 Feb 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice.
Wiersma H, Gatti A, …, Kuipers F, Tietge UJ
Hepatology 2009 Oct 50(4):1263-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 3 Feb 2010

Must Read
F1000 Factor 6.4

Hypothesis
New Finding
Controversial
 Rare variants create synthetic genome-wide associations.
Dickson SP, Wang K, …, Hakonarson H, Goldstein DB
PLoS Biol 2010 8(1):e1000294 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Isaac Kohane / Thomas Hund
First evaluation 2 Feb 2010 | Latest evaluation 5 Feb 2010

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F1000 Factor 3.0

New Finding
 Emi2 Inhibition of the APC/C Absolutely Requires Emi2 Binding via the C-terminal RL Tail.
Ohe M, Kawamura Y, …, Nakajo N, Sagata N
Mol Biol Cell 2010 Jan 20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Peter Jackson
Evaluated 2 Feb 2010

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F1000 Factor 3.0

Hypothesis
New Finding
Tech Advance
 Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
Sibanda BL, Chirgadze DY, Blundell TL
Nature 2010 Jan 7 463(7277):118-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nick Rhind
Evaluated 28 Jan 2010


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