9-Feb-2010
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Structural Biology
Biomacromolecule-Ligand Interactions
Cell Signalling & Trafficking Structures
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Protein Folding
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Structure: RNA
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Must Read
F1000 Factor
6.0
Hypothesis
New Finding
The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates.
Liu B, Larsson L, …, Grantham J, Nystrom T
Cell
2010
140
:257-67 [
full text
]
Selected by
| Andrei Fagarasanu, Fred Mast and Richard Rachubinski
Evaluated 8 Feb 2010
Recommended
F1000 Factor
3.0
New Finding
Tech Advance
Mechanistic details of a protein-protein association pathway revealed by paramagnetic relaxation enhancement titration measurements.
Fawzi NL, Doucleff M, Suh JY, Clore GM
Proc Natl Acad Sci U S A
2010 Jan 26
107
(4):1379-84 [
abstract on PubMed
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full text
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Selected by
| Mikael Akke
Evaluated 8 Feb 2010
Recommended
F1000 Factor
3.0
Confirmation
New Finding
Modulation of mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects.
Acin-Perez R, Salazar E, …, Schon EA, Manfredi G
EMBO Mol Med
2009 Nov
1
(8-9):392-406 [
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Selected by
| Eduardo Rial
Evaluated 5 Feb 2010
Recommended
F1000 Factor
3.0
Hypothesis
New Finding
T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility.
Borbulevych OY, Piepenbrink KH, …, Sewell AK, Baker BM
Immunity
2009 Dec 18
31
(6):885-96 [
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Selected by
| Elizabeth L Read, Andrej Komrlj and Arup Chakraborty
Evaluated 4 Feb 2010
Recommended
F1000 Factor
3.0
Confirmation
New Finding
Transient assembly of F-actin by phagosomes delays phagosome fusion with lysosomes in cargo-overloaded macrophages.
Liebl D, Griffiths G
J Cell Sci
2009 Aug 15
122
(Pt 16):2935-45 [
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Selected by
| Mary Ann McDowell
Evaluated 4 Feb 2010
Recommended
F1000 Factor
3.0
Confirmation
New Finding
Function of the nucleotide exchange activity of vav1 in T cell development and activation.
Saveliev A, Vanes L, …, Rittinger K, Tybulewicz VL
Sci Signal
2009
2
(101):ra83 [
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Selected by
| Hun Sik Kim and Eric Long
Evaluated 3 Feb 2010
Recommended
F1000 Factor
3.0
Confirmation
New Finding
Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice.
Wiersma H, Gatti A, …, Kuipers F, Tietge UJ
Hepatology
2009 Oct
50
(4):1263-72 [
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Selected by
| Bruno Stieger
Evaluated 3 Feb 2010
Must Read
F1000 Factor
6.4
Hypothesis
New Finding
Controversial
Rare variants create synthetic genome-wide associations.
Dickson SP, Wang K, …, Hakonarson H, Goldstein DB
PLoS Biol
2010
8
(1):e1000294 [
abstract on PubMed
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FREE full text
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Selected by
| Isaac Kohane
/ Thomas Hund
First evaluation 2 Feb 2010 | Latest evaluation 5 Feb 2010
Recommended
F1000 Factor
3.0
New Finding
Emi2 Inhibition of the APC/C Absolutely Requires Emi2 Binding via the C-terminal RL Tail.
Ohe M, Kawamura Y, …, Nakajo N, Sagata N
Mol Biol Cell
2010 Jan 20 [
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Selected by
| Peter Jackson
Evaluated 2 Feb 2010
Recommended
F1000 Factor
3.0
Hypothesis
New Finding
Tech Advance
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
Sibanda BL, Chirgadze DY, Blundell TL
Nature
2010 Jan 7
463
(7277):118-21 [
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Selected by
| Nick Rhind
Evaluated 28 Jan 2010
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