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Must Read
F1000 Factor 6.0

New Finding
 Spatial control of EGF receptor activation by reversible dimerization on living cells.
Chung I, Akita R, …, Schlessinger J, Mellman I
Nature 2010 Mar 7 [abstract on PubMed] [related articles] [full text]
Selected by | Kermit Carraway
Evaluated 15 Mar 2010

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.
Rajagopal S, Kim J, …, Gerard C, Lefkowitz RJ
Proc Natl Acad Sci U S A 2010 Jan 12 107(2):628-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Brett Adams
Evaluated 11 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Light activation of rhodopsin: insights from molecular dynamics simulations guided by solid-state NMR distance restraints.
Hornak V, Ahuja S, …, Reeves PJ, Smith SO
J Mol Biol 2010 Feb 26 396(3):510-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Bowie
Evaluated 10 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 Phosphorylation and membrane dissociation of the ARF exchange factor GBF1 in mitosis.
Morohashi Y, Balklava Z, …, Hughes H, Lowe M
Biochem J 2010 Feb 23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marie-Pierre Golinelli-Cohen and Catherine Jackson
Evaluated 10 Mar 2010

Must Read
F1000 Factor 6.4

Confirmation
Hypothesis
New Finding
 Interaction with AKAP79 Modifies the Cellular Pharmacology of PKC.
Hoshi N, Langeberg LK, …, Newton AC, Scott JD
Mol Cell 2010 Feb 26 37(4):541-550 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carmen Dessauer / Lily Jan
First evaluation 9 Mar 2010 | Latest evaluation 11 Mar 2010

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F1000 Factor 3.0

New Finding
Controversial
 Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time.
Aleksic M, Dushek O, …, Coombs D, van der Merwe PA
Immunity 2010 Feb 26 32(2):163-174 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz
Evaluated 9 Mar 2010

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F1000 Factor 3.0

Hypothesis
New Finding
 Structural basis for the Rho- and phosphoinositide-dependent localization of the exocyst subunit Sec3.
Yamashita M, Kurokawa K, …, Nakano A, Fukai S
Nat Struct Mol Biol 2010 Feb 17(2):180-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Danming Tang and Yanzhuang Wang
Evaluated 8 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Structure-function study of the N-terminal domain of exocyst subunit Sec3.
Baek K, Knodler A, …, Guo W, Dominguez R
J Biol Chem 2010 Feb 5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Danming Tang and Yanzhuang Wang
Evaluated 8 Mar 2010

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F1000 Factor 6.0

New Finding
Refutation
 Irs1 serine 307 promotes insulin sensitivity in mice.
Copps KD, Hancer NJ, …, Walsh C, White MF
Cell Metab 2010 Jan 11(1):84-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Derek P Brazil and Brian Hemmings
Evaluated 4 Mar 2010

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F1000 Factor 3.0

New Finding
 Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP.
Krasteva PV, Fong JC, …, Yildiz FH, Sondermann H
Science 2010 Feb 12 327(5967):866-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ann Stock
Evaluated 4 Mar 2010


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