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Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Vinculin regulates cell-surface E-cadherin expression by binding to {beta}-catenin.
Peng X, Cuff LE, Lawton CD, Demali KA
J Cell Sci 2010 Jan 19 [abstract on PubMed] [related articles] [full text]
Selected by | Ronen Zaidel-Bar
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Refutation
 Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation.
Popp D, Xu W, …, Robinson RC, Schumacher M
J Biol Chem 2010 Jan 27 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Edward Egelman
Evaluated 8 Feb 2010

Recommended
F1000 Factor 3.0

Hypothesis
Tech Advance
 Mechanism of folding chamber closure in a group II chaperonin.
Zhang J, Baker ML, …, Frydman J, Chiu W
Nature 2010 Jan 21 463(7279):379-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jose Valpuesta
Evaluated 5 Feb 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Modulation of mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects.
Acin-Perez R, Salazar E, …, Schon EA, Manfredi G
EMBO Mol Med 2009 Nov 1(8-9):392-406 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Eduardo Rial
Evaluated 5 Feb 2010

Must Read
F1000 Factor 6.0

New Finding
 Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.
Byun JS, Wong MM, …, Ozato K, Gardner K
Proc Natl Acad Sci U S A 2009 Nov 17 106(46):19286-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Reines
Evaluated 3 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.
Miotto B, Struhl K
Mol Cell 2010 37:57-66 [full text]
Selected by | Jessica Downs
Evaluated 3 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 Emi2 Inhibition of the APC/C Absolutely Requires Emi2 Binding via the C-terminal RL Tail.
Ohe M, Kawamura Y, …, Nakajo N, Sagata N
Mol Biol Cell 2010 Jan 20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Peter Jackson
Evaluated 2 Feb 2010

Recommended
F1000 Factor 3.0

Tech Advance
 Protease accessibility laddering: a proteomic tool for probing protein structure.
Dokudovskaya S, Williams R, …, Chait BT, Rout MP
Structure 2006 Apr 14(4):653-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kenneth Sawin
Evaluated 28 Jan 2010

Must Read
F1000 Factor 6.0

New Finding
 Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch.
Kulshina N, Baird NJ, Ferré-D'Amaré AR
Nat Struct Mol Biol 2009 Dec 16(12):1212-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Aaron S Burton and Niles Lehman
Evaluated 27 Jan 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells.
Ezratty EJ, Bertaux C, Marcantonio EE, Gundersen GG
J Cell Biol 2009 Nov 30 187(5):733-47 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Morgan and Martin Humphries
Evaluated 25 Jan 2010


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