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22-Mar-2010

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Browse > Physiology > Gastrointestinal Physiology
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	Recommended
F1000 Factor 3.0

Hypothesis

New Finding

Bicarbonate secretion of mouse cholangiocytes involves Na(+)-HCO(3) (-) cotransport in addition to Na(+)-independent Cl(-)/HCO(3) (-) exchange.
Uriarte I, Banales JM, …, Prieto J, Medina JF
Hepatology 2009 Oct 23 51(3):891-902 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Bruno Stieger

Evaluated 18 Mar 2010

	Recommended
F1000 Factor 3.0

New Finding

Novel Drug Target

Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity.
Catalán V, Gómez-Ambrosi J, …, Salvador J, Frühbeck G
Nutr Metab Cardiovasc Dis 2010 Jan 25 [abstract on PubMed] [related articles] [full text]

Selected by | David Alpers

Evaluated 17 Mar 2010

	Must Read
F1000 Factor 4.8

New Finding

Novel Drug Target

Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice.
Harmon GS, Dumlao DS, …, Dong H, Glass CK
Nat Med 2010 Mar 16(3):313-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | William H Colledge

/ Hugo De Jonge

First evaluation 15 Mar 2010 | Latest evaluation 18 Mar 2010

	Recommended
F1000 Factor 3.2

Confirmation

New Finding

Tech Advance

Quantitative organellar proteomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas.
Chen X, Sans MD, …, Andrews PC, Williams JA
J Proteome Res 2010 Feb 5 9(2):885-96 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Gyorgy Lur and Alexei Tepikin / Oleg Gerasimenko

First evaluation 2 Mar 2010 | Latest evaluation 17 Mar 2010

	Must Read
F1000 Factor 6.0

Hypothesis

New Finding

Novel Drug Target

S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model.
Lu SC, Ramani K, …, Moats R, Grant E
Hepatology 2009 Aug 50(2):462-71 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Henry Lin
Evaluated 26 Feb 2010

	Must Read
F1000 Factor 6.0

New Finding

Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis.
Ko SB, Mizuno N, …, Muallem S, Goto H
Gastroenterology 2010 Jan 14 [abstract on PubMed] [related articles] [full text]

Selected by | Hwei Ling Ong and Indu Ambudkar
Evaluated 25 Feb 2010

	Exceptional
F1000 Factor 9.0

Hypothesis

New Finding

Tech Advance

The primary transcriptome of the major human pathogen Helicobacter pylori.
Sharma CM, Hoffmann S, …, Stadler PF, Vogel J
Nature 2010 Feb 17 [abstract on PubMed] [related articles] [full text]

Selected by | Alberto Danielli and Vincenzo Scarlato
Evaluated 24 Feb 2010

	Must Read
F1000 Factor 6.4

Hypothesis

New Finding

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity.
Clarke TB, Davis KM, …, Yu Y, Weiser JN
Nat Med 2010 Feb 16(2):228-31 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Bärbel Stecher and Wolf-Dietrich Hardt / Giorgio Napolitani and Vincenzo Cerundolo
First evaluation 24 Feb 2010 | Latest evaluation 12 Mar 2010

	Recommended
F1000 Factor 3.0

New Finding

Relation of Serum Serotonin Levels to Bone Density and Structural Parameters in Women.
Mödder UI, Achenbach SJ, …, Melton LJ, Khosla S
J Bone Miner Res 2009 Jul 13 [abstract on PubMed] [related articles] [full text]

Selected by | Susan Ott
Evaluated 23 Feb 2010

	Recommended
F1000 Factor 3.0

New Finding

Novel Drug Target

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis.
Yadav VK, Balaji S, …, Karsenty G, Ducy P
Nat Med 2010 Feb 7 [abstract on PubMed] [related articles] [full text]

Selected by | Gabriel R Linares and Subburaman Mohan
Evaluated 23 Feb 2010

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