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F1000 Factor 3.0

Confirmation
 Smooth muscle-specific deletion of nitric oxide-sensitive guanylyl cyclase is sufficient to induce hypertension in mice.
Groneberg D, König P, …, Koesling D, Friebe A
Circulation 2010 Jan 26 121(3):401-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Schwartz
Evaluated 19 Mar 2010

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F1000 Factor 6.0

New Finding
 Molecular basis of infrared detection by snakes.
Gracheva EO, Ingolia NT, …, Weissman JS, Julius D
Nature 2010 Mar 14 [abstract on PubMed] [related articles] [full text]
Selected by | Roger Hardie
Evaluated 18 Mar 2010

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F1000 Factor 6.0

Hypothesis
New Finding
 Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.
Popp C, Dean W, …, Jacobsen SE, Reik W
Nature 2010 Feb 25 463(7284):1101-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nina Papavasiliou
Evaluated 17 Mar 2010

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F1000 Factor 3.0

New Finding
 Drosophila timeless2 is required for chromosome stability and circadian photoreception.
Benna C, Bonaccorsi S, …, Costa R, Sandrelli F
Curr Biol 2010 Feb 23 20(4):346-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steven Reppert
Evaluated 16 Mar 2010

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F1000 Factor 6.4

Confirmation
Hypothesis
New Finding
Tech Advance
 Whole-Genome Sequencing in a Patient with Charcot-Marie-Tooth Neuropathy.
Lupski JR, Reid JG, …, Muzny DM, Gibbs RA
N Engl J Med 2010 Mar 10 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sue Malcolm / Anthony Antonellis
Evaluated 15 Mar 2010

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F1000 Factor 3.0

New Finding
 Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis.
Garin I, Edghill EL, …, Perez de Nanclares G, Hattersley AT
Proc Natl Acad Sci U S A 2010 Feb 16 107(7):3105-10 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dorothy Kakoola and Ivan Gerling
Evaluated 10 Mar 2010

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F1000 Factor 3.0

Confirmation
New Finding
 Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.
Du H, Cline MS, …, Thornton CA, Ares M
Nat Struct Mol Biol 2010 Feb 17(2):187-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaolin Zhang and Robert Darnell
Evaluated 8 Mar 2010

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F1000 Factor 3.0

Tech Advance
 A new generation of homology search tools based on probabilistic inference.
Eddy SR
Genome Inform 2009 Oct 23(1):205-11 [abstract on PubMed] [related articles] [order article]
Selected by | Nick Grishin
Evaluated 4 Mar 2010

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F1000 Factor 3.0

New Finding
Tech Advance
 Computational identification of gene-social environment interaction at the human IL6 locus.
Cole SW, Arevalo JM, …, Sheridan JF, Seeman TE
Proc Natl Acad Sci U S A 2010 Feb 22 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Victor Reus
Evaluated 3 Mar 2010

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F1000 Factor 6.0

New Finding
Novel Drug Target
 Tlr2 is critical for diet-induced metabolic syndrome in a murine model.
Himes RW, Smith CW
FASEB J 2009 Oct 19 24 [abstract on PubMed] [related articles] [full text]
Selected by | Zachary M Weil and Randy Nelson
Evaluated 3 Mar 2010


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