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Recommended
F1000 Factor 3.0

Hypothesis
 Use of spermatozoal mRNA profiles to study gene-environment interactions in human germ cells.
Linschooten JO, Van Schooten FJ, …, Anderson D, Godschalk RW
Mutat Res 2009 Jul 10 667(1-2):70-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bhaskar Gollapudi
Evaluated 9 Mar 2010

Recommended
F1000 Factor 3.0

Confirmation
Tech Advance
 Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion.
Fujita K, Horie M, …, Iwahashi H, Nakanishi J
Toxicol Lett 2009 Dec 15 191(2-3):109-17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Burcham
Evaluated 8 Mar 2010

Recommended
F1000 Factor 3.0

Tech Advance
 A new generation of homology search tools based on probabilistic inference.
Eddy SR
Genome Inform 2009 Oct 23(1):205-11 [abstract on PubMed] [related articles] [order article]
Selected by | Nick Grishin
Evaluated 4 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
Yauch RL, Dijkgraaf GJ, …, Rudin CM, de Sauvage FJ
Science 2009 Oct 23 326(5952):572-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dong Soo Kang and Jeffrey Benovic
Evaluated 1 Mar 2010

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
Novel Drug Target
 ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia.
McCarl CA, Picard C, …, Fischer A, Feske S
J Allergy Clin Immunol 2009 Dec 124(6):1311-1318.e7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lanny Rosenwasser
Evaluated 18 Feb 2010

Recommended
F1000 Factor 3.0

Tech Advance
 Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells.
Si-Tayeb K, Noto FK, …, Dalton S, Duncan SA
Hepatology 2010 Jan 51(1):297-305 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alexander Ploss
Evaluated 3 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Genome-wide and fine-resolution association analysis of malaria in West Africa.
Jallow M, Teo YY, …, Wellcome Trust Case Control Consortium, Malaria Genomic Epidemiology Network
Nat Genet 2009 May 24 41 [abstract on PubMed] [related articles] [full text]
Selected by | Kenneth Vernick
Evaluated 28 Jan 2010

Exceptional
F1000 Factor 8.2

New Finding
Novel Drug Target
 Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.
Doi M, Takahashi Y, …, van der Horst GT, Okamura H
Nat Med 2010 Jan 16(1):67-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chung Owyang / Robert Carey / Zachary Weil and Randy Nelson
First evaluation 19 Jan 2010 | Latest evaluation 25 Jan 2010


Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population.
Siljander HT, Simell S, …, Simell O, Knip M
Diabetes 2009 Dec 58(12):2835-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carla Greenbaum
Evaluated 14 Jan 2010

Recommended
F1000 Factor 3.0

Tech Advance
 Quantitative phenotyping via deep barcode sequencing.
Smith AM, Heisler LE, …, Giaever G, Nislow C
Genome Res 2009 Oct 19(10):1836-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tao Xu and Anuj Kumar
Evaluated 23 Dec 2009


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