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Browse > Pharmacology & Drug Discovery > Pharmacokinetics & Drug Delivery
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Exceptional
F1000 Factor 9.0

Tech Advance
 Rational design of cationic lipids for siRNA delivery.
Semple SC, Akinc A, …, Madden TD, Hope MJ
Nat Biotechnol 2010 Feb 28(2):172-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rudy Juliano
Evaluated 19 Mar 2010


Must Read
F1000 Factor 6.0

New Finding
 Rapid beta-lactam-induced lysis requires successful assembly of the cell division machinery.
Chung HS, Yao Z, …, Beckwith J, Kahne D
Proc Natl Acad Sci U S A 2009 Dec 22 106(51):21872-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Will Stubbings and Harald Labischinski
Evaluated 16 Mar 2010

Recommended
F1000 Factor 3.0

Tech Advance
 Silk-elastinlike recombinant polymers for gene therapy of head and neck cancer: from molecular definition to controlled gene expression.
Gustafson J, Greish K, …, Cappello J, Ghandehari H
J Control Release 2009 Dec 16 140(3):256-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Parsa Kazemi-Esfarjani and Albert La Spada
Evaluated 15 Mar 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Embryonic stem cell-derived L1 overexpressing neural aggregates enhance recovery in Parkinsonian mice.
Cui YF, Hargus G, …, Schachner M, Bernreuther C
Brain 2010 Jan 133(Pt 1):189-204 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wei-Li Kuan and Roger Barker
Evaluated 11 Mar 2010

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
 Lipophilicity in drug discovery.
Waring MJ
Expert Opin Drug Discov 2010 5:235-48 [full text]
Selected by | Peter Grootenhuis
Evaluated 9 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation.
Rihel J, Prober DA, …, Peterson RT, Schier AF
Science 2010 Jan 15 327(5963):348-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 9 Mar 2010

Recommended
F1000 Factor 3.0

Confirmation
 Combinatorial control of suicide gene expression by tissue-specific promoter and microRNA regulation for cancer therapy.
Wu C, Lin J, …, Zeng J, Wang S
Mol Ther 2009 Dec 17(12):2058-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Gantier and Bryan Williams
Evaluated 5 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1.
Rimon G, Sidhu RS, …, Lucchesi BR, Smith WL
Proc Natl Acad Sci U S A 2010 Jan 5 107(1):28-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Hollenberg
Evaluated 1 Mar 2010


Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 The efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus neoformans for the treatment of meningitis.
Wang H, Xu K, …, Yang YY, Li L
Biomaterials 2010 Apr 31(10):2874-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Xiaorong Lin and Matthew Sachs
Evaluated 26 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages.
Wilson AA, Murphy GJ, …, Suki B, Kotton DN
J Clin Invest 2010 Jan 120(1):379-89 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mary Dinauer
Evaluated 22 Feb 2010


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