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Recommended
F1000 Factor 3.0

Hypothesis
 Justification of biowaiver for carbamazepine, a low soluble high permeable compound, in solid dosage forms based on IVIVC and gastrointestinal simulation.
Kovacevic I, Parojcic J, …, Tubic-Grozdanis M, Langguth P
Mol Pharm 2009 Jan-Feb 6(1):40-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Isabel Gonzalez Alvarez and Marival Bermejo
Evaluated 3 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin.
Knight SD, Adams ND, …, Auger KR, Dhanak D
ACS Medicinal Chemistry Letters 2010 Jan 19:Early Online Publication [full text]
Selected by | Roger Freidinger
Evaluated 3 Feb 2010

Recommended
F1000 Factor 3.0

Tech Advance
 Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells.
Si-Tayeb K, Noto FK, …, Dalton S, Duncan SA
Hepatology 2010 Jan 51(1):297-305 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alexander Ploss
Evaluated 3 Feb 2010

Recommended
F1000 Factor 3.0

Confirmation
 An adenosine nucleoside inhibitor of dengue virus.
Yin Z, Chen YL, …, Keller TH, Shi PY
Proc Natl Acad Sci U S A 2009 Dec 1 106(48):20435-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kai Dallmeier and Johan Neyts
Evaluated 28 Jan 2010

Recommended
F1000 Factor 3.0

New Finding
 Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events.
Lammert C, Bjornsson E, Niklasson A, Chalasani N
Hepatology 2009 Sep 14 [abstract on PubMed] [related articles] [full text]
Selected by | Nicholas Meanwell
Evaluated 20 Jan 2010

Recommended
F1000 Factor 3.0

New Finding
 Abacavir-lamivudine versus tenofovir-emtricitabine for initial HIV-1 therapy.
Sax PE, Tierney C, …, Geiseler PJ, Daar ES
N Engl J Med 2009 Dec 3 361(23):2230-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | George Thompson and Thomas Patterson
Evaluated 18 Jan 2010

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism.
Steinfeld R, Grapp M, …, Grosso S, Gärtner J
Am J Hum Genet 2009 Sep 85(3):354-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arjan de Brouwer and Hans van Bokhoven
Evaluated 13 Jan 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 CNSB004 (Leconotide) Causes Antihyperalgesia Without Side Effects When Given Intravenously: A Comparison with Ziconotide in a Rat Model of Diabetic Neuropathic Pain.
Kolosov A, Goodchild CS, Cooke I
Pain Med 2009 Nov 25 [abstract on PubMed] [related articles] [full text]
Selected by | David Adams
Evaluated 7 Jan 2010

Must Read
F1000 Factor 6.4

New Finding
Tech Advance
 External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers.
Kubo A, Nagao K, …, Sasaki H, Amagai M
J Exp Med 2009 Dec 21 206(13):2937-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Anderson / Fabio Bagnoli and Rino Rappuoli
First evaluation 5 Jan 2010 | Latest evaluation 3 Feb 2010

Recommended
F1000 Factor 3.0

Hypothesis
 Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower log D limits based on permeability.
Waring MJ
Bioorg Med Chem Lett 2009 19:2844-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Zoran Rankovic
Evaluated 18 Dec 2009


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