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Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Structure-Activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-Resistant Prostate Cancer (CRPC).
Jung ME, Ouk S, …, Tran C, Wongvipat J
J Med Chem 2010 Mar 10 [abstract on PubMed] [related articles] [full text]
Selected by | Robert Fecik
Evaluated 19 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.
Aronov AM, Tang Q, …, ter Haar E, Xie X
J Med Chem 2009 Oct 22 52(20):6362-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Xiaohua Huang and Gerald Shipps
Evaluated 18 Mar 2010

Exceptional
F1000 Factor 9.0

New Finding
 Closthioamide: An Unprecedented Polythioamide Antibiotic from the Strictly Anaerobic Bacterium Clostridium cellulolyticum.
Lincke T, Behnken S, …, Roth M, Hertweck C
Angew Chem Int Ed Engl 2010 Mar 8 49(11):2011-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolfgang Buckel
Evaluated 17 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
 The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancy.
Leistikow RL, Morton RA, …, Wagner K, Voskuil MI
J Bacteriol 2010 Mar 192(6):1662-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Will Stubbings and Harald Labischinski
Evaluated 16 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice.
Banno R, Zimmer D, …, Yang W, Bence KK
J Clin Invest 2010 Mar 1 120(3):720-34 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Eric Gustafson
Evaluated 16 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 A broad-spectrum antiviral targeting entry of enveloped viruses.
Wolf MC, Freiberg AN, …, Jung ME, Lee B
Proc Natl Acad Sci U S A 2010 Feb 16 107(7):3157-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith White
Evaluated 15 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody.
Arslan F, Smeets MB, …, Pasterkamp G, de Kleijn DP
Circulation 2010 Jan 5 121(1):80-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Julian Ormerod and Michael Frenneaux
Evaluated 15 Mar 2010

Must Read
F1000 Factor 4.8

Hypothesis
New Finding
Controversial
Novel Drug Target
 The Alzheimer's Disease-Associated Amyloid beta-Protein Is an Antimicrobial Peptide.
Soscia SJ, Kirby JE, …, Tanzi RE, Moir RD
PLoS One 2010 5(3):e9505 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Kodadek / John Lazo
First evaluation 15 Mar 2010 | Latest evaluation 18 Mar 2010

Recommended
F1000 Factor 3.0

Tech Advance
 Silk-elastinlike recombinant polymers for gene therapy of head and neck cancer: from molecular definition to controlled gene expression.
Gustafson J, Greish K, …, Cappello J, Ghandehari H
J Control Release 2009 Dec 16 140(3):256-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Parsa Kazemi-Esfarjani and Albert La Spada
Evaluated 15 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Blueprint for antimicrobial hit discovery targeting metabolic networks.
Shen Y, Liu J, …, Wiest O, Oltvai ZN
Proc Natl Acad Sci U S A 2010 Jan 19 107(3):1082-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 11 Mar 2010


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