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Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody.
Arslan F, Smeets MB, …, Pasterkamp G, de Kleijn DP
Circulation 2010 Jan 5 121(1):80-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Julian Ormerod and Michael Frenneaux
Evaluated 15 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1.
Rimon G, Sidhu RS, …, Lucchesi BR, Smith WL
Proc Natl Acad Sci U S A 2010 Jan 5 107(1):28-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Hollenberg
Evaluated 1 Mar 2010


Must Read
F1000 Factor 6.0

Hypothesis
Tech Advance
 Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients.
Heusser K, Tank J, …, Luft FC, Jordan J
Hypertension 2010 Mar 55(3):619-26 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Erica Wehrwein and Gregory Fink
Evaluated 23 Feb 2010


Recommended
F1000 Factor 3.0

New Finding
 The Small GTPase Ral Couples the angiotensin II type 1 receptor to the activation of phospholipaseC-delta1.
Godin CM, Ferreira LT, …, Cregan SP, Ferguson SS
Mol Pharmacol 2009 Dec 16 [abstract on PubMed] [related articles] [full text]
Selected by | Robert Michell
Evaluated 18 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 TIMP2 Deficiency Accelerates Adverse Post-Myocardial Infarction Remodeling Because of Enhanced MT1-MMP Activity Despite Lack of MMP2 Activation.
Kandalam V, Basu R, …, Oudit GY, Kassiri Z
Circ Res 2010 Jan 7 [abstract on PubMed] [related articles] [full text]
Selected by | Anthony Dart
Evaluated 16 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 Effects of renal perfusion pressure on renal medullary hydrogen peroxide and nitric oxide production.
Jin C, Hu C, …, Ito S, Cowley AW
Hypertension 2009 Jun 53(6):1048-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Maria Carolina Gongora and David Harrison
Evaluated 10 Feb 2010

Must Read
F1000 Factor 4.8

Hypothesis
New Finding
Novel Drug Target
 Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction.
Madhur MS, Lob HE, …, Guzik TJ, Harrison DG
Hypertension 2010 Feb 55(2):500-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Imig / David Pollock
First evaluation 8 Feb 2010 | Latest evaluation 23 Feb 2010


Exceptional
F1000 Factor 9.0

New Finding
Tech Advance
Novel Drug Target
 Platelet membrane proteomics: a novel repository for functional research
Lewandrowski U, Wortelkamp S, …, Walter U, Sickmann A
Blood 2009 114 [full text]
Selected by | Yotis Senis and Steve Watson
Evaluated 5 Feb 2010

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice.
Wiersma H, Gatti A, …, Kuipers F, Tietge UJ
Hepatology 2009 Oct 50(4):1263-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 3 Feb 2010

Must Read
F1000 Factor 6.4

Hypothesis
New Finding
Controversial
 Rare variants create synthetic genome-wide associations.
Dickson SP, Wang K, …, Hakonarson H, Goldstein DB
PLoS Biol 2010 8(1):e1000294 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Isaac Kohane / Thomas Hund
First evaluation 2 Feb 2010 | Latest evaluation 5 Feb 2010


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