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Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Structure-Activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-Resistant Prostate Cancer (CRPC).
Jung ME, Ouk S, …, Tran C, Wongvipat J
J Med Chem 2010 Mar 10 [abstract on PubMed] [related articles] [full text]
Selected by | Robert Fecik
Evaluated 19 Mar 2010

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity.
Catalán V, Gómez-Ambrosi J, …, Salvador J, Frühbeck G
Nutr Metab Cardiovasc Dis 2010 Jan 25 [abstract on PubMed] [related articles] [full text]
Selected by | David Alpers
Evaluated 17 Mar 2010

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.
Cantó C, Jiang LQ, …, Zierath JR, Auwerx J
Cell Metab 2010 Mar 3 11(3):213-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony Means
Evaluated 17 Mar 2010

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F1000 Factor 3.0

New Finding
 SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Hirschey MD, Shimazu T, …, Kahn CR, Verdin E
Nature 2010 Mar 4 464(7285):121-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony Means
Evaluated 17 Mar 2010

Must Read
F1000 Factor 6.0

New Finding
 Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells.
Lapensee EW, Lapensee CR, …, Afton S, Ben-Jonathan N
Cancer Lett 2010 Apr 28 290(2):167-173 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin van den Berg
Evaluated 16 Mar 2010

Exceptional
F1000 Factor 8.0

Hypothesis
New Finding
Controversial
 SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1.
Pacholec M, Bleasdale JE, …, Withka J, Ahn K
J Biol Chem 2010 Mar 12 285(11):8340-51 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Kyriakis / Bryan Roth
First evaluation 8 Mar 2010 | Latest evaluation 16 Mar 2010

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F1000 Factor 3.0

New Finding
 Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport.
Wang J, Knight ZA, …, Shokat KM, Pearce D
Am J Physiol Renal Physiol 2008 Sep 295(3):F843-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carolyn Ecelbarger
Evaluated 4 Mar 2010

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F1000 Factor 3.0

Confirmation
 Postmenopausal hormone therapy and asthma onset in the E3N cohort.
Romieu I, Fabre A, …, Leynaert B, Clavel-Chapelon F
Thorax 2010 Feb 8 [abstract on PubMed] [related articles] [full text]
Selected by | Henry Burger
Evaluated 3 Mar 2010


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F1000 Factor 6.0

New Finding
Novel Drug Target
 Tlr2 is critical for diet-induced metabolic syndrome in a murine model.
Himes RW, Smith CW
FASEB J 2009 Oct 19 24 [abstract on PubMed] [related articles] [full text]
Selected by | Zachary M Weil and Randy Nelson
Evaluated 3 Mar 2010

Exceptional
F1000 Factor 9.0

New Finding
Novel Drug Target
 Rfx6 directs islet formation and insulin production in mice and humans.
Smith SB, Qu HQ, …, Polychronakos C, German MS
Nature 2010 Feb 11 463(7282):775-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Qingchun Tong and Perry Bickel
Evaluated 2 Mar 2010


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