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Browse > Pharmacology & Drug Discovery > Gastrointestinal Pharmacology
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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model.
Lu SC, Ramani K, …, Moats R, Grant E
Hepatology 2009 Aug 50(2):462-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Henry Lin
Evaluated 26 Feb 2010

Must Read
F1000 Factor 6.0

New Finding
 Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis.
Ko SB, Mizuno N, …, Muallem S, Goto H
Gastroenterology 2010 Jan 14 [abstract on PubMed] [related articles] [full text]
Selected by | Hwei Ling Ong and Indu Ambudkar
Evaluated 25 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis.
Yadav VK, Balaji S, …, Karsenty G, Ducy P
Nat Med 2010 Feb 7 [abstract on PubMed] [related articles] [full text]
Selected by | Gabriel R Linares and Subburaman Mohan
Evaluated 23 Feb 2010


Recommended
F1000 Factor 3.0

New Finding
 Effect of human rotavirus vaccine on severe diarrhea in African infants.
Madhi SA, Cunliffe NA, …, Han HH, Neuzil KM
N Engl J Med 2010 Jan 28 362(4):289-98 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael McChesney
Evaluated 16 Feb 2010

Recommended
F1000 Factor 3.0

Hypothesis
 Justification of biowaiver for carbamazepine, a low soluble high permeable compound, in solid dosage forms based on IVIVC and gastrointestinal simulation.
Kovacevic I, Parojcic J, …, Tubic-Grozdanis M, Langguth P
Mol Pharm 2009 Jan-Feb 6(1):40-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Isabel Gonzalez Alvarez and Marival Bermejo
Evaluated 3 Feb 2010

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Controversial
 Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.
Stieler K, Schulz C, …, Stocking C, Fischer N
Virology 2010 Jan 26 [abstract on PubMed] [related articles] [full text]
Selected by | David Alpers
Evaluated 3 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli.
Brierley SM, Hughes PA, …, Rychkov GY, Blackshaw LA
Gastroenterology 2009 Dec 137(6):2084-2095.e3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Felix Viana
Evaluated 3 Feb 2010

Recommended
F1000 Factor 3.0

New Finding
 Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events.
Lammert C, Bjornsson E, Niklasson A, Chalasani N
Hepatology 2009 Sep 14 [abstract on PubMed] [related articles] [full text]
Selected by | Nicholas Meanwell
Evaluated 20 Jan 2010

Must Read
F1000 Factor 6.0

Tech Advance
 Generation of functional human hepatic endoderm from human induced pluripotent stem cells.
Sullivan GJ, Hay DC, …, Iredale JP, Wilmut I
Hepatology 2010 Jan 51(1):329-35 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 19 Jan 2010

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
 Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety.
Williams DL, Baskin DG, Schwartz MW
Endocrinology 2009 Apr 150(4):1680-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andreas Stengel and Yvette Taché
Evaluated 12 Jan 2010


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